The importance of functional diagnostics in determining the cause of antisecretary therapy inefficiency in a patient with heartburn: clinical observation
https://doi.org/10.21518/2079-701X-2021-5-46-53
Abstract
One of the main symptoms of gastroesophageal reflux disease is heartburn, for the relief of which proton pump inhibitors are traditionally prescribed. However, there are frequent cases of heartburn, refractory to antisecretory therapy, when there is no complete relief of the symptom or only a partial clinical effect. The reason for an unsatisfactory response may be the functional genesis of heartburn. The purpose of the presented clinical observation is to demonstrate the heterogeneity of patients with heartburn, the role of functional research methods in the differential diagnosis of various conditions that accompany this symptom. A 42-year-old patient was admitted for an additional clinical examination with complaints of heartburn refractory to antisecretory therapy, which included high-resolution esophageal manometry, 24-hours pH-impedance. The manometric assessment of the structure and function of the lower esophageal sphincter, as well as the contractility of the thoracic esophagus, revealed no violations. The data of 24-hours pH-impedance demonstrated the absence of pathological reflux and the association of active symptoms with refluxes, which determined the functional nature of heartburn and explained the ineffectiveness of treatment with proton pump inhibitors. Heartburn can be functional in nature and significantly reduce the quality of life of patients. Functional heartburn requires different management tactics from gastroesophageal reflux disease, which is based on an adequate differential diagnosis, including functional research methods such as high-resolution esophageal manometry and 24-hours pH-impedance measurement, which allow to exclude other conditions accompanied by similar symptoms.
About the Authors
E. V. Barkalova
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Teaching Associate of Department of Propaedeutics of Internal Diseases and Gastroenterology, Head of Laboratory of Functional Methods of Research in Gastroenterology,
20, Bldg. 1, Delegateskaya St., Moscow, 127473
D. N. Andreev
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Cand. Sci. (Med.), Associate Professor of Department of Propaedeutics of Internal Diseases and Gastroenterology, Research Associate of Laboratory of Functional Methods of Research in Gastroenterology,
20, Bldg. 1, Delegateskaya St., Moscow, 127473
M. A. Ovsepian
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Research Technician of Department of Propaedeutics of Internal Diseases and Gastroenterology, Research Associate of Laboratory of Functional Methods of Research in Gastroenterology,
20, Bldg. 1, Delegateskaya St., Moscow, 127473
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For citations:
Barkalova EV, Andreev DN, Ovsepian MA. The importance of functional diagnostics in determining the cause of antisecretary therapy inefficiency in a patient with heartburn: clinical observation. Meditsinskiy sovet = Medical Council. 2021;(5):46-53. (In Russ.) https://doi.org/10.21518/2079-701X-2021-5-46-53
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