Preview

Meditsinskiy sovet = Medical Council

Advanced search

Prevalence, awareness, treatment and control of diabetes mellitus in the population

https://doi.org/10.21518/ms2025-120

Abstract

Introduction. The annual increase in prevalence and dangerous consequences make diabetes mellitus (DM) a global problem.
Aim. To review modern studies for the period of 2000–2024 on awareness, treatment and control of DM in various populations with a focus on identifying regional and demographic characteristics.
Materials and methods. The search for publications was carried out in the electronic databases of Google Scholar (https://scholar.google.ru/), PubMed (https://www.ncbi.nlm.nih.gov/pubmed/), eLIBRARY.ru (https://www.elibrary.ru/), international and domestic journals.
Results and conclusion. The results showed a stable trend of increasing prevalence of DM worldwide in a wide range from 2 to 30.1% (1990–2022); awareness of the presence of DM was approximately 60%, with the highest overall rates in high-income countries – 68% and the lowest in low-income countries – 41%. The level of diabetes control varies from 9.8 to 60.4%. Despite the availability of verified tools reflected in the guidelines for DM management, diabetes control is very difficult – more than 50% of diabetic patients do not achieve target levels of glycaemia and glycosylated hemoglobin (HbA1c). Inefficient control or delayed initiation of treatment increase the risk of DM complications and death. Younger people achieve target HbA1c levels significantly less often than elder people. Compliance with the recommendations for treatment and prevention of DM is consistently assessed by a series of studies: EUROASPIRE V, NHANES, NCD Risk factor Collaboration. There are multiple reasons for inefficient DM control, and the development of individual approaches to improve adherence to treatment, access to medical resources, and independent management of DM is justified.

About the Authors

E. S. Mazurenko
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation

Elena. S. Mazurenko, Cand. Sci. (Med.), Researcher, Laboratory of laboratories of clinical and preventive studies of therapeutic and endocrine diseases

175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia



A. N. Ryabikov
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation

Andrew N. Ryabikov, Dr. Sci. (Med.), Professor, Chief Researcher Laboratory of Ethiopathogenesis and Clinics of Internal Diseases

175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia



E. V. Mazdorova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation

Ekaterina V. Mazdorova, Cand. Sci. (Med.), Senior Researcher, Laboratory of Ethiopathogenesis and clinics of internal diseases

175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia



S. K. Malyutina
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation

Sofia K. Malyutina, Dr. Sci. (Med.), Professor, Head of the Laboratory of Ethiopathogenesis and Clinics of Internal Diseases

175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia



References

1. Dedov II, Shestakova MV, Vikulova OK, Zheleznyakova AV, Isakov MA, Sazonova DV, Mokrysheva NG. Diabetes mellitus in the Russian Federation: dynamics of epidemiological indicators according to the Federal Register of Diabetes Mellitus for the period 2010–2022. Diabetes Mellitus. 2023;26(2):104–123. (In Russ.) https://doi.org/10.14341/DM13035.

2. Mustafina SV, Rymar OD, Malyutina SK, Denisova DV, Shcherbakova LV, Voevoda MI. Prevalence of diabetes in the adult population of Novosibirsk. Diabetes Mellitus. 2017;20(5):329–334. (In Russ.) https://doi.org/10.14341/DM8744.

3. Malyutina S, Mazurenko E, Mazdorova E, Shapkina M, Avdeeva E, Mustafina S et al. The Profile of Glucose Lowering Therapy in Persons with Type 2 Diabetes Mellitus in an Aging Russian Population. J Pers Med. 2022;12(10):1689. https://doi.org/10.3390/jpm12101689.

4. Mazurenko ES. Fall risk factors as predictors of osteoporotic fractures in people with diabetes mellitus. Meditsinsky Sovet. 2019;(4):104–107. (In Russ.) https://doi.org/10.21518/2079-701X-2019-4-104-107.

5. Vikulova OK, Zheleznyakova AV, Isakov MА, Serkov AA, Shestakova MV, Dedov II. Dynamic monitoring of HbA1c in Russian regions: data comparison of mobile medical center (Diamodul) and national diabetes register of Russian Federation. Diabetes Mellitus. 2020;23(2):104–112. (In Russ.) https://doi.org/10.14341/DM12327.

6. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospect observatiiveonal study. BMJ. 2000;321(7258):405–12. https://doi.org/10.1136/bmj.321.7258.405.

7. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M et al. Management of hyperglycemia in type 2 diabetes, 2015: a patientcentered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38(1):140–149. https://doi.org/10.2337/dc14-2441.

8. Chinese Diabetes Society. Guidelines for the prevention and control of type 2 diabetes in China (2017 Edition). Chin J Pract Intern Med. 2018;38:292–344. https://doi.org/10.3760/cma.j.issn.1674-5809.2018.01.003.

9. American Diabetes Association. Glycemic Targets. Diabetes Care. 2017;40(Suppl 1):S48–S56. https://doi.org/10.2337/dc17-S009.

10. Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA et al. AACE/ACE comprehensive diabetes management algorithm 2015. Endocr Pract. 2015;21(4):438–447. https://doi.org/10.4158/EP15693.CS.

11. Buse JB, Wexler DJ, Tsapas A, Rossing P, Mingrone G, Mathieu C et al. 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2020;63(2):221–228. https://doi.org/10.1007/s00125-019-05039-w.

12. Dedov I, Shestakova M, Mayorov A, Mokrysheva N, Andreeva E, Bezlepkina O et al. Standards of Specialized Diabetes Care. Diabetes Mellitus. 2023;26(2S):1–157. (In Russ.) https://doi.org/10.14341/DM13042.

13. Juarez DT, Ma C, Kumasaka A, Shimada R, Davis J. Failure to reach target glycated a1c levels among patients with diabetes who are adherent to their antidiabetic medication. Popul Health Manag. 2014;17(4):218–223. https://doi.org/10.1089/pop.2013.0099.

14. Khunti K, Gomes MB, Pocock S, Shestakova MV, Pintat S, Fenici P et al. Therapeutic inertia in the treatment of hyperglycaemia in patients with type 2 diabetes: A systematic review. Diabetes Obes Metab. 2018;20(2):427–437. https://doi.org/10.1111/dom.13088.

15. Kotseva K, De Backer G, De Bacquer D, Ryden L, Hoes A, Grobbee D et al. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry. Eur J Prev Cardiol. 2019;26(8):824–835. https://doi.org/10.1177/2047487318825350.

16. Fang M, Wang D, Coresh J, Selvin E. Trends in Diabetes Treatment and Control in U.S. Adults, 1999–2018. N Engl J Med. 2021;384(23):2219–2228. https://doi.org/10.1056/NEJMsa2032271.

17. Wang L, Li X, Wang Z, Bancks MP, Carnethon MR, Greenland P et al. Trends in Prevalence of Diabetes and Control of Risk Factors in Diabetes Among US Adults, 1999–2018. JAMA. 2021;326(8):1–13. https://doi.org/10.1001/jama.2021.9883.

18. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024;404(10467):2077–2093. https://doi.org/10.1016/S0140-6736(24)02317-1.

19. Basit A, Fawwad A, Qureshi H, Shera AS. Prevalence of diabetes, prediabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016–2017. BMJ Open. 2018;8(8):e020961. https://doi.org/10.1136/bmjopen-2017-020961.

20. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. https://doi.org/10.1016/j.diabres.2021.109119.

21. GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402(10397):203–234. https://doi.org/10.1016/S0140-6736(23)01301-6.

22. Park PH, Pastakia SD. Access to hemoglobin A1c in rural Africa: a difficult reality with severe consequences. J Diabetes Res. 2018;2018:6093595. https://doi.org/10.1155/2018/6093595.

23. Masis L, Kanya L, Kiogora J, Kiapi L, Tulloch C, Alani AH. Estimating treatment costs for uncomplicated diabetes at a hospital serving refugees in Kenya. PLoS ONE. 2022;17(10):e0276702. https://doi.org/10.1371/journal.pone.0276702.

24. Anjana RM, Unnikrishnan R, Deepa M, Pradeepa R, Tandon N, Das AK et al. Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17) Lancet Diabetes Endocrinol. 2023;11(7):474–489. https://doi.org/10.1016/S2213-8587(23)00119-5.

25. Rannan-Eliya RP, Wijemunige N, Perera P, Kapuge Y, Gunawardana N, Sigera C et al. Prevalence of diabetes and pre-diabetes in Sri Lanka: a new global hotspot-estimates from the Sri Lanka Health and Ageing Survey 2018/2019. BMJ Open Diabetes Res Care. 2023;11(1):e003160. https://doi.org/10.1136/bmjdrc-2022-003160.

26. Gujral UP, Prabhakaran D, Pradeepa R, Kandula NR, Kondal D, Deepa M et al. Isolated HbA1c identifies a different subgroup of individuals with type 2 diabetes compared to fasting or post-challenge glucose in Asian Indians: the CARRS and MASALA studies. Diabetes Res Clin Pract. 2019;153:93–102. https://doi.org/10.1016/j.diabres.2019.05.026.

27. Fuentes S, Mandereau-Bruno L, Regnault N, Bernillon P, Bonaldi C, Cosson E, Fosse-Edorh S. Is the type 2 diabetes epidemic plateauing in France? A nationwide population-based study. Diabetes Metab. 2020;46(6):472–479. https://doi.org/10.1016/j.diabet.2019.12.006.

28. Yan Y, Wu T, Zhang M, Li C, Liu Q, Li F. Prevalence, awareness and control of type 2 diabetes mellitus and risk factors in Chinese elderly population. BMC Public Health. 2022;22(1):1382. https://doi.org/10.1186/s12889-022-13759-9.

29. Lu W, Pikhart H, Tamosiunas A, Kubinova R, Capkova N, Malyutina S et al. Prevalence, awareness, treatment and control of hypertension, diabetes and hypercholesterolemia, and associated risk factors in the Czech Republic, Russia, Poland and Lithuania: a cross-sectional study. BMC Public Health. 2022;22(1):883. https://doi.org/10.1186/s12889-022-13260-3.

30. Bikbov MM, Fayzrakhmanov RR, Kazakbaeva GM, Zainullin RM, Arslangareeva II, Gilmanshin TR et al. Prevalence, awareness and control of diabetes in Russia: The Ural Eye and Medical Study on adults aged 40+ years. PLoS ONE. 2019;14(4):e0215636. https://doi.org/10.1371/journal.pone.0215636.

31. Lascar N, Brown J, Pattison H, Barnett AH, Bailey CJ, Bellary S. Type 2 diabetes in adolescents and young adults. Lancet Diabetes Endocrinol. 2018;6(1):69–80. https://doi.org/10.1016/S2213-8587(17)30186-9.

32. Langholz PL, Wilsgaard T, Njølstad I, Jorde R, Hopstock LA. Trends in known and undiagnosed diabetes, HbA1c levels, cardiometabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys: the population-based Tromsø Study 1994–2016. BMJ Open. 2021;11(3):e041846. https://doi.org/10.1136/bmjopen-2020-041846.

33. Jørgensen ME, Ellervik C, Ekholm O, Johansen NB, Carstensen B. Estimates of prediabetes and undiagnosed type 2 diabetes in Denmark: The end of an epidemic or a diagnostic artefact? Scand J Public Health. 2020;48(1):106–112. https://doi.org/10.1177/1403494818799606.

34. Babar ZU, Ramzan S, El-Dahiyat F, Tachmazidis I, Adebisi A, Hasan SS. The Availability, Pricing, and Affordability of Essential Diabetes Medicines in 17 Low-, Middle-, and High-Income Countries. Front Pharmacol. 2019;10:1375. https://doi.org/10.3389/fphar.2019.01375.

35. Ewen M, Zweekhorst M, Regeer B, Laing R. Baseline assessment of WHO’s target for both availability and affordability of essential medicines to treat non-communicable diseases. PLoS ONE. 2017;12(2):e0171284. https://doi.org/10.1371/journal.pone.0171284.

36. Shahrestanaki E, Khonsari NM, Seif E, Baygi F, Ejtahed HS, Sheidaei A et al. The worldwide trend in diabetes awareness, treatment, and control from 1985 to 2022: a systematic review and meta-analysis of 233 populationrepresentative studies. Front Public Health. 2024;12:1305304. https://doi.org/10.3389/fpubh.2024.1305304.

37. Khunti K, Chen H, Cid-Ruzafa J, Fenici P, Gomes MB, Hammar N et al. Glycaemic control in patients with type 2 diabetesinitiating second-line therapy: Results from the global DISCOVER study programme. Diabetes Obes Metab. 2020;22(1):66–78. https://doi.org/10.1111/dom.13866.

38. El-Kebbi IM, Cook CB, Ziemer DC, Miller CD, Gallina DL, Phillips LS. Association of younger age with poor glycemic control and obesity in urban african americans with type 2 diabetes. Arch Intern Med. 2003;163(1):69–75. https://doi.org/10.1001/archinte.163.1.69.

39. Feng BY, Huang C, Cao J, Dong Z, Liu FC, Ji LN et al. Diabetes awareness, treatment, control rates and associated risk factors among Beijing residents in 2011: A cross-sectional survey. Chronic Dis Transl Med. 2016;2(3):147–158. https://doi.org/10.1016/j.cdtm.2016.11.011.

40. Alzaheb RA, Altemani AH. The prevalence and determinants of poor glycemic control among adults with type 2 diabetes mellitus in Saudi Arabia. Diabetes Metab Syndr Obes. 2018;11:15–21. https://doi.org/10.2147/DMSO.S156214.

41. Yousefzadeh G, Shokoohi M, Najafipour H. Inadequate control of diabetes and metabolic indices among diabetic patients: a population based study from the Kerman Coronary Artery Disease Risk Study (KERCADRS). Int J Health Policy Manag. 2014;4(5):271–277. https://doi.org/10.15171/ijhpm.2015.06.

42. Kosiborod M, Gomes MB, Nicolucci A, Pocock S, Rathmann W, Shestakova MV et al. Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program). Cardiovasc Diabetol. 2018;17(1):150. https://doi.org/10.1186/s12933-018-0787-8.

43. Lipska KJ, Yao X, Herrin J, McCoy RG, Ross JS, Steinman MA et al. Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013. Diabetes Care. 2017;40(4):468–475. https://doi.org/10.2337/dc16-0985.


Review

For citations:


Mazurenko ES, Ryabikov AN, Mazdorova EV, Malyutina SK. Prevalence, awareness, treatment and control of diabetes mellitus in the population. Meditsinskiy sovet = Medical Council. 2025;(6):270-279. (In Russ.) https://doi.org/10.21518/ms2025-120

Views: 75


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)