Causal treatment of congenital cytomegalovirus infection: current achievements and routine practice
https://doi.org/10.21518/2079-701X-2016-07-136-139
Abstract
The key factor for the effective treatment of infectious diseases is timely causal treatment [1, 2]. However, due to various reasons, the arsenal of etiotropic drugs for the treatment of congenital infections (CIs) has been significantly small [3–6]. At the same time, in the treatment of bacterial CIs (congenital syphilis, congenital listeriosis, congenital Streptococcus agalactiae infection, congenital chlamydiosis, congenital ureaplasmosis, congenitan mycoplasmosis and other), only some of the effective antibiotics are not safe enough for use in newborns. What is more, until recently, there were practically no etiotropic therapies except Aciclovir for the treatment of viral CIs [2–6]. In view of the fact that cytomegalovirus infection (CMV) is the most common viral CI (in the US, it is diagnosed in 1% of all live births), the absence of etiotropic therapies has been particularly critical for the management of congenital CMV infection [2].
About the Authors
A. L. Zaplatnikov
Russian Medical Academy of Postgraduate Education, Moscow
Children's City Clinical Hospital named after Z.A. Bashlyaeva, Moscow Healthcare Department
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
N. V. Sadova
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
O. Y. Shipulina
Central Research Institute of Epidemiology under Rospotrebnadzor, Moscow
Russian Federation
PhD in Medicine
Russian Federation
PhD in Medicine
L. N. Кaraseva
Children's City Clinical Hospital named after Z.A. Bashlyaeva, Moscow Healthcare Department
Russian Federation
Russian Federation
V. N. Podkopaev
Russian Medical Academy of Postgraduate Education, Moscow
Children's City Clinical Hospital named after Z.A. Bashlyaeva, Moscow Healthcare Department
Russian Federation
PhD in medicine
Russian Federation
PhD in medicine
E. A. Domonova
Central Research Institute of Epidemiology under Rospotrebnadzor, Moscow
Russian Federation
PhD in medicine
Russian Federation
PhD in medicine
T. S. Skachkova
Central Research Institute of Epidemiology under Rospotrebnadzor, Moscow
Russian Federation
Russian Federation
V. S. Smirnova
Central Research Institute of Epidemiology under Rospotrebnadzor, Moscow
Russian Federation
Russian Federation
References
1. Покровский В.И., Пак С.Г., Брико Н.И., Данилкин Б.К. Инфекционные болезни и эпидемиология. М.: ГЭОТАР-медиа, 2007. 816 с.
2. Red Book: 2015. Report of the Committee on Infection Diseases. 30th ed. Kimberlin DW, Brady M.T., Jackson MA, Long SS. Elk Grove Village, IL: American Academy of Pediatrics, 2015, 1022 р.
3. Протоколы диагностики, лечения и профилактики внутриутробных инфекций у новорожденных детей Российской ассоциации специалистов перинатальной медицины (методические рекомендации). М.: ГОУ ВУНМЦ МЗ РФ, 2001.
4. Шабалов Н.П. Внутриутробные инфекции. В кн. Неонатология в 2 т. Под ред. Н.П. Шабалова. М.: МЕДпресс-информ, 2004, Т.2. С. 61-108.
5. Дегтярев Д.Н., Заплатников А.Л. Внутриутробные инфекции. В кн: Неонатология. Национальное руководство. Краткое издание. Под ред. акад. РАМН Н.Н. Володина. М.: ГЭОТАР-медиа, 2013. С. 725-729.
6. Садова Н.В., Заплатников А.Л., Шипулина О.Ю. и др. «TORCH-синдром»: клиническая диагностика и этиологическая верификация. РМЖ, 2014, 3: 194-196.
7. Gertrude B. Elion – Biographical. Nobelprize.org. Nobel Media. [Электронный ресурс] Режим доступа: http://www.nobelprize.org/nobel_prizes/medicine/laureates/1988/elion-bio.html (Дата обращения: 26.06.2016).
8. Маркова И.В., Шабалов Н.П. Клиническая фармакология новорожденных. Л.: Медицина, 1984. 288 с.
9. Государственный реестр лекарственных средств РФ [Электронный ресурс] Режим доступа: http://grls.rosminzdrav.ru/grls.aspx (Дата обращения: 26.06.2016).
10. Сytomegalovirus infection. Red Book: 2012. Report of the Committee on Infection Diseases.29th ed. Pickering LK, Baker CJ, Kimberlin DW, Long SS. Elk Grove Village, IL: American Academy of Pediatrics, 2012: 300-305.
11. Сytomegalovirus infection. Red Book: 2015. Report of the Committee on Infection Diseases.30th ed. Kimberlin DW, Brady MT, Jackson MA, Long SS. Elk Grove Village, IL: American Academy of Pediatrics, 2015: 317-322.
12. Коровина Н.А., Заплатников А.Л. Врожденная цитомегаловирусная инфекция. В кн. Рациональная фармакотерапия детских заболеваний. Под ред. А.А. Баранова, Н.Н. Володина, Г.А. Самсыгиной. М.: Литтерра, 2007. в 2 кн. Книга 1. С. 187-197.
13. Textbook of Pediatric Infectious Diseases. Ed. J.D. Cherry, Seventh Edition, New York-London: Feigin and Cherry's, 2009, 265.
14. Nassetta L, Kimberlin D, Whitley R. Treatment of congenital cytomegalovirus infection: implications for future therapeutic strategies. J Antimicrob Chemother., 2009 May, 63(5): 862-867.
15. Swanson Е., Schleiss М. Congenital Cytomegalovirus Infection: New Prospects for Prevention and Therapy. Pediatr Clin North Am., 2013 Apr, 60(2): 10.1016.
Review
For citations:
Zaplatnikov AL, Sadova NV, Shipulina OY, Кaraseva LN, Podkopaev VN, Domonova EA, Skachkova TS, Smirnova VS. Causal treatment of congenital cytomegalovirus infection: current achievements and routine practice. Meditsinskiy sovet = Medical Council. 2016;(7):136-139. (In Russ.) https://doi.org/10.21518/2079-701X-2016-07-136-139
Views:
935
Email this article 