Preview

Медицинский Совет

Расширенный поиск

ВИТАМИННО-МИНЕРАЛЬНЫЕ КОМПЛЕКСЫ И БЕРЕМЕННОСТЬ: ИЗВЕСТНЫЕ ФАКТЫ И ДОКАЗАТЕЛЬНЫЕ ДАННЫЕ

https://doi.org/10.21518/2079-701X-2016-12-24-33

Полный текст:

Аннотация

Адекватное поступление микронутриентов  в организм беременной женщины или женщины, планирующей  беременность, является обязательным   условием нормального течения беременности и развития плода. Ряд авторов показал эффективность витаминно-минеральных комплексов в снижении риска осложений беременности, пороков развития плода и неблагоприятных отдаленных последствий для его здоровья. В данной статье представлен обзор последних данных, касающихся  роли  важнейших   витаминов  и минералов  в профилактике  пороков  развития плода  и осложнений  беременности. Подробно разобраны последствия витаминного и минерального дефицита во время беременности и пути их восполнения. Помимо широко известных данных, также отмечено значение эпигенетических изменений в фетальном программировании, лежащем в основе развития многих заболеваний во взрослом возрасте, а также определяющем состояние здоровья не только ребенка, но и его потомства.

Об авторе

К. Т. Муминова
Научный центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова, Москва
Россия


Список литературы

1. Godfrey KM, Barker DJ. Fetal programming and adult health. Public Health Nut, 2001. 4(2B): 611-24.

2. Geraghty AA, Lindsay KL, Alberdi G et al. Nutrition During Pregnancy Impacts Offspring’s Epigenetic Status-Evidence from Human and Animal Studies. Metab Insights, 2015, 8(Suppl 1): 41-47.

3. McKay JA, Mathers JC. Diet induced epigenetic changes and their implications for health. Acta Physiol (Oxf ), 2011, 202(2): 103-18.

4. Gernand AD, Schulze KJ, Stewart CP et al. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol, 2016, 12(5): 274-89.

5. Pannia E, Cho CE, Kubant R et al. Role of maternal vitamins in programming health and chronic disease. Nutr Rev, 2016, 74(3): 166-80.

6. Rautiainen S, Manson JE, Lichtenstein AH, Sesso HD. Dietary supplements and disease prevention – a global overview. Nat Rev Endocrinol, 2016, 12(7): 407-20.

7. Кузнецова И.В., Коновалов В.А. Фолиевая кислота и ее роль в женской репродукции. Гинекология, 2014, 16(4). / Kuznetsova I.V., Konovalov V.A. Folic acid and its role in female reproduction. Gynecology, 2014, 16(4).

8. Gernand AD, Schulze KJ, Stewart CP et al. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol, 2016, 12(5): 274-89.

9. Громова О.А., Трошин И.Ю. Применение фолиевой кислоты в акушерстве и гинекологии. РСЦ ЮНЕСКО, 2009, Москва. / Gromova O.A., Troshin I.Y. Application of folic acid in obstetrics and gynecology. RCC UNESCO, 2009, Moscow.

10. Molloy AM, Kirke PN, Brody LC et al. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food nutrition bulletin, 2008, 29 (Suppl.2): 101-11.

11. Wolski H, Kocięcka M, Mrozikiewicz AE et al. Coexistence of the 677C>T and 1298A>C MTHFR polymorphisms and its significance in the population of Polish women. Ginekol Pol, 2015, 86(10): 742-7.

12. Balogun OO, da Silva Lopes K, Ota E et al. Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev, 2016, 5.

13. Gaskins AJ, Afeiche MC, Wright DL et al. Dietary folate and reproductive success among women undergoing assisted reproduction. Obstet Gynecol, 2014, 124: 801-9.

14. Gaskins AJ, Rich-Edwards JW, Hauser R et al. Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Obstet Gynecol, 2014, 124: 23-31.

15. Czeizel AE, Vereczkey A, Szabo ́ I. Folic acid in pregnant women associated with reduced prevalence of severe congenital heart defects in their children: a national population-based case-control study. Eur J Obstet Gynecol Reprod Biol, 2015, 193: 34-9.

16. Rampersaud G, Kauwell G, Hutson AD et al. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr, 2000, 72: 998-1003.

17. Anderson O, Sant K, Dolinoy D. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism, and DNA methylation. J Nutr Biochem, 2012, 23(8): 853-859.

18. Steegers-Theunissen RP, Twigt J, Pestinger V & Sinclair KD. The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism. Hum. Reprod. Update, 2013, 19: 640-655.

19. Sinclair KD, Allegrucci C, Singh R et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc. Natl Acad. Sci., 2007, 104: 19351-19356.

20. Lyall K, Schmidt RJ, Hertz-Picciotto I. Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int. J. Epidemiol, 2014, 43(2): 443-64.

21. Suren P, Roth C, Bresnahan M et al. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA, 2013, 309: 570-577.

22. Chaney SG. Chapter 27: Principles of nutrition II: Micronutrients. Section 27.6: Energy releasing water soluble vitamins. Textbook of Biochemistry with Clinical Correlations, 2002, 5th Edition: 1148-53.

23. Pietrzik Bailey , Shane B. Folic acid and L-5methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacok, 2010, 8(49): 535-548.

24. Matthews A, Haas DM, O’Mathúna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev, 2015, 9.

25. Krapels IP, van Rooij IA, Ocke MC. et al. Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring. European Journal of Nutrition, 2004, 43(1): 7-14.

26. Czeizel AE, Puho E, Banhidy F, Acs N. Oral pyridoxine during pregnancy: potential protective effect for cardiovascular malformations. Drugs, 2004, 5(5): 259-69.

27. Salam RA, Zuberi NF, Bhutta ZA. Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes. Cochrane Database Syst Rev, 2015, 6.

28. Browne JL, Klipstein-Grobusch K, Franx A, Grobbee DE. Prevention of Hypertensive Disorders of Pregnancy: a Novel Application of the Polypill Concept. Curr Cardiol Rep, 2016, 18(6): 59.

29. Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food nutrition bulletin, 2008, 29(Suppl.2): 126-31.

30. Ars CL, Nijs IM, Marroun HE et al. Prenatal folate, homocysteine and vitamin B12 levels and child brain volumes, cognitive development and psychological functioning: the Generation R Study. Br J Nutr., 2016: 1-9.

31. Kim NH, Kirsner RS. Nicotinamide in Dermatology. Expert Rev Dermatol, 2010, 5: 23-9.

32. Williams A, Ramsden D. Nicotinamide: a double edged sword. Parkinsonism Relat Disord., 2005, 11: 413-20.

33. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem, 1990, 1: 228-37.

34. Мандоева С.С., Суханова Г.А., Подзолкова Н.М. и соавт. Влияние гипергомоцистеинемии на репродуктивные потери и ее коррекция во время беременности. Гематология и трансфузиология, 2009, 6: 34-37. / Mandoeva S.S., Sukhanova G.A., Podzolkova N.M. et al. Hyperhomocysteinemia effect on reproductive losses and its correction during pregnancy. Hematology and transfusiology, 2009, 6: 34-37.

35. Титов В.Н. Биохимические маркеры эндотелия и его роль в единении функционально разных пулов межклеточной среды и пула внутрисосудистой жидкости. Клиническая лабораторная диагностика, 2007, 4: 6-15. / Titov V.N. Biochemical endothelium markers and its role in union of functionally different pools of intercellular medium and intravascular fluid pool. Clinical Laboratory Diagnostics, 2007, 4: 6-15.

36. Озолиня Л.A., Ефимов B.C., Абдулраб A.C. и соавт. Российский вестник акушера-гинеколога. 2003, 4: 26-29. Ozolinya L.A., Efimov V.S., Abdulrab A.S. et al. Russian Herald of Obstetrician-Gynecologist. 2003, 4: 26-29.

37. McNulty H, Pentieva K, Hoey L et al. Nutrition throughout life: folate. Int J Vitam Nutr Res, 2012, 5(82): 348-54.

38. Jacob Selhub J, Morris MS, Jacques PF, Rosenberg IH. Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am J Clin Nutr, 2009, 89(2): 702-706.

39. Ефимов B.C. Али Цакалоф. Гомоцистеинемия в патогенезе тромбоваскулярной болезни и атеросклероза. Лабораторная медицина, 1999, 2: 44-47. / Efimov V.S., Ali Tsakalov. Homocisteinemia in pathogenesis of thrombovascular disease and atherosclerosis. Laboratory Medicine, 1999, 2: 44-47.

40. Кашежева А.З., Ефимов B.C. Лекарственное происхождение гипергомоцистеинемии. Тромбоз гемостаз и реология, 2001, 1(5): 14-18. / Kazhesheva A.Z., Efimov V.S. Pharmaceutical hyperhomocisteinemia origin. Thrombosis, Hemostasis and Rheology, 2001, 1(5): 14-18.

41. Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. The Metabolic & Molecular Bases of Inherited Disease, 2001: 2007-2056.

42. Merphy MM, Fernandez-Ballart JD. Homocysteine in pregnancy. Clin. Chem., 2011, 9(60): 741-745.

43. Hogeveen M, Blom HJ, den Heijer M. Maternal homocysteine and small for gestational age offspring: systematic review and meta-analysis. Amer. J. Clin. Nutr., 2012, 1(95): 130-136.

44. Milman N, Byg KE, Hvas AМ et al. Erythrocyte folate, plasma folate and plasma homocysteine during normal pregnancy and postpartum: a longitudinal study comprising 404 Danish women. Eur J Haematol, 2006, 76: 200-5.

45. van Engeland M, Weijenberg MP, Roemen М et al. Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res, 2003, 63: 3133-3137.

46. Ouyang S, Li Y, Liu Z et al. Association between MTR A2756G and MTRR A66G polymorphisms and maternal risk for neural tube defects: a meta-analysis. Gene, 2013, 515(2): 308-12.

47. Depeint F, Bruce WR, Shangari N et al. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact, 2006, 163(1-2): 94-112.

48. Rumbold A, Ota E, Nagata C и соавт. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev, 2015, 9.

49. Allan KM, Prabhu N, Craig LC et al. Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. The European respiratory journal, 2015, 45: 1027-36.

50. Lodge CJ, Dharmage SC. Breastfeeding and perinatal exposure, and the risk of asthma and allergies. Curr Opin Allergy Clin Immunol, 2016, 16(3): 231-6.

51. Zingg JM, Meydani M, Azzi A. α-tocopheryl phosphate – an activated form of vitamin E important for angiogenesis and vasculogenesis? Biofactors, 2012, 38: 24-33.

52. Milman N, Agger AO, Nielsen OJ. Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women. Dan Med Bull, 1991.

53. Alwan NA, Greenwood DC, Simpson NA et al. Dietary iron intake during early pregnancy and birth outcomes in a cohort of British women. Hum Reprod, 2011, 26: 911-19.

54. Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr, 2005, 81: 1218-22.

55. Insel BJ, Schaefer CA, McKeague IW et al. Maternal iron deficiency and the risk of schizophrenia in offspring. Arch Gen Psychiatry, 2008, 65: 1136-44.

56. Fowden AL, Moore T. Maternal-fetal resource allocation: co-operation and conflict. Placenta, 2012, 33(Suppl. 2): 11-15.

57. Sandovici I, Hoelle K, Angiolini E, Constancia M. Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming. Reprod. Biomed. Online, 2012, 25: 68-89.

58. Antony AC. In utero physiology: role of folic acid in nutrient delivery and fetal development. Am. J. Clin. Nutr., 2007, 85: 598-603.

59. Donangelo CM, King JC. Maternal zinc intakes and homeostatic adjustments during pregnancy and lactation. Nutrients, 2012, 4: 782-798.

60. Cao C, O’Brien KO. Pregnancy and iron homeostasis: an update. Nutr. Rev., 2013, 71: 35-51.

61. Zijp IM, Korver O, Tijburg LB. Effect of tea and other dietary factors on iron absorption. Crit Rev Food Sci Nutr, 2000, 40: 371-98.

62. Allen LH. Biological mechanisms that might underlie iron’s effects on fetal growth and preterm birth. J. Nutr., 2001, 131: 581-589.

63. De-Regil LM, Jefferds ME, Sylvetsky AC, Dowswell T. Intermittent iron supplementation for improving nutrition and development in children under 12 years of age. Cochrane Database Syst. Rev., 2011, 12.

64. Andersson M. Iodine deficiency in Europe: a continuing public health problem. World Health Organization [online], 2007.

65. Zimmermann MB. The Importance of Adequate Iodine during Pregnancy and Infancy. World Rev Nutr Diet, 2016, 115: 118-24.

66. Pedersen IB, Knudsen N, Carle A et al. A cautious iodization programme bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population. Clin Endocrinol, 2011, 75: 120-126.

67. Krauss-Etschmann S, Shadid R, Campoy C et al. Nutrition and Health Lifestyle (NUHEAL) Study Group . Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. Am J Clin Nutr, 2007, 85(5): 1392-1400.

68. Kotwal S, Jun M, Sullivan D et al. Omega 3 Fatty acids and cardiovascular outcomes: systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes, 2012, 5: 808-818.

69. Kajarabille N, Hurtado JA, Peña-Quintana L. Omega-3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress. Matern Child Nutr, 2016.

70. Lauritzen L, Hansen HS, Jørgensen MH et al. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res, 2001, 40(1-2): 1-94.

71. Steer CD, Lattka E, Koletzko B et al. Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am J Clin Nutr, 2013, 98(6): 1575-1582.

72. Steenweg-de Graaff J, Tiemeier H, Ghassabian A et al. Maternal Fatty Acid Status During Pregnancy and Child Autistic Traits The Generation R Study. American Journal of Epidemiology Advance Access, 2016.

73. Strain JJ, Yeates AJ, van Wijngaarden E et al. Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. Am J Clin Nutr, 2015, 101(3): 530-537.

74. Qawasmi A, Landeros-Weisenberger A, Bloch MH. Meta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity. Pediatrics, 2013, 131(1): 262-272.

75. Wadhwani NS, Pisal HR, Mehendale SS et al. A prospective study of maternal fatty acids, micronutrients and homocysteine and their association with birth outcome. Matern Child Nutr, 2015, 11(4): 559-73.

76. Grosso G, Pajak A, Marventano S и соавт. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive metaet al соавт. Hopelessness, depression, and early markers of endothelial dysfunction in U.S. adults. Psychosom Med, 2010, 72: 613-619.

77. Bourre JM. Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. J Nutr Health Aging, 2004, 8: 163-174.


Просмотров: 202


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)