CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH CHRONIC OBSTRUCIVE PULMONARY DISEASE IN COMBINATION WITH THE HYPERTONIC DISEASE: NEW DIRECTIONS OF PATHOGENETIC THERAPY
https://doi.org/10.21518/2079-701X-2016-15-90-95
Abstract
The purpose of the study was to study of effects of sulodexide on clinical and functional parameters in patients with chronic obstructive pulmonary disease (COPD) in combination with hypertension. 40 COPD patients were examined. Patients were divided into two groups of 20 people. One group received only basic COPD therapy and antihypertensive treatment, the other group - basic and antihypertensive therapy in combination with sulodexide. After a year of observation the assessment of the clinical course of the disease, and ventilatory lung function, cardiopulmonary hemodynamics, endothelium-dependent vasomotor function was done.
In patients, additionally treated with sulodexide, the following parameters were marked: stabilization of blood pressure parameters, reduction of dizziness and headaches, increase of tolerance to physical load, reducing the number of exacerbations, improvement in spirometry, lung diffusion capacity, improvement of pulmonary hemodynamics parameters and improvement of endothelium-dependent
vasodilation. Thus, the positive effect of sulodexide on clinical and functional parameters indicates the feasibility of further study of the use of angioprotectors in complex pathogenetic therapy of COPD.
About the Authors
O. N. TITOVA
Scientific and Research Institute of Pulmonology of the State Budgetary Education Establishment of Higher Professional Education of I.P. Pavlov SPBSMU
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
N. A. KUZUBOVA
Scientific and Research Institute of Pulmonology of the State Budgetary Education Establishment of Higher Professional Education of I.P. Pavlov SPBSMU
Russian Federation
MD
Russian Federation
MD
A. A. SHUMILOV
Scientific and Research Institute of Pulmonology of the State Budgetary Education Establishment of Higher Professional Education of I.P. Pavlov SPBSMU
Russian Federation
Russian Federation
V. A. VOLCHKOV
Scientific and Research Institute of Pulmonology of the State Budgetary Education Establishment of Higher Professional Education of I.P. Pavlov SPBSMU;
Federal State Budgetary Education Establishment of Higher Professional Education Saint-Petersburg State University
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
A. Y. GICHKIN
Scientific and Research Institute of Pulmonology of the State Budgetary Education Establishment of Higher Professional Education of I.P. Pavlov SPBSMU
Russian Federation
PhD in medicine
Russian Federation
PhD in medicine
M. M. ZABEZHINSKY
Federal State Budgetary Education Establishment of Higher Professional Education Saint-Petersburg State Pediatric Medical University of the Ministry of Health of Russia;
Scientific and Research Institute of Pulmonology of the State Budgetary Education Establishment of Higher Professional Education of I.P. Pavlov SPBSMU
Russian Federation
PhD in medicine
Russian Federation
PhD in medicine
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Review
For citations:
TITOVA ON, KUZUBOVA NA, SHUMILOV AA, VOLCHKOV VA, GICHKIN AY, ZABEZHINSKY MM. CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH CHRONIC OBSTRUCIVE PULMONARY DISEASE IN COMBINATION WITH THE HYPERTONIC DISEASE: NEW DIRECTIONS OF PATHOGENETIC THERAPY. Meditsinskiy sovet = Medical Council. 2016;(15):90-95. (In Russ.) https://doi.org/10.21518/2079-701X-2016-15-90-95
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