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КОМБИНИРОВАННЫЕ РЕЖИМЫ ХИМИОТЕРАПИИ ПРИ РАКЕ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ

https://doi.org/10.21518/2079-701X-2017-6-62-70

Аннотация

Рак поджелудочной железы характеризуется агрессивным течением и высоким метастатическим потенциалом, в связи с чем в большинстве случаев заболевание выявляется на неоперабельных стадиях. Основным методом лечения местнораспространенного и метастатического рака поджелудочной железы является химиотерапия. До недавнего времени стандартом химиотерапии данной патологии считалась монотерапия гемцитабином, пока в клиническую практику не вошли более эффективные режимы комбинированной химиотерапии (FOLFIRINOX и комбинация nab-паклитаксела с гемцитабином). Назначение данных схем химиотерапии лимитирует относительно высокая токсичность, что делает невозможным их применение у ослабленных пациентов и у больных с серьезной сопутствующей патологией. В настоящей работе рассматриваются критерии выбора оптимального режима комбинированной химиотерапии на основе оценки состояния пациента, возможности управления побочными эффектами химиотерапии, а также молекулярно-биологические характеристики опухоли.

Об авторах

А. С. ПОПОВА
Российский онкологический научный центр им. Н.Н. Блохина Минздрава России
Россия


И. А. ПОКАТАЕВ
Российский онкологический научный центр им. Н.Н. Блохина Минздрава России
Россия
к.м.н.


С. А. ТЮЛЯНДИН
Российский онкологический научный центр им. Н.Н. Блохина Минздрава России
Россия
д.м.н., профессор


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Рецензия

Для цитирования:


ПОПОВА А.С., ПОКАТАЕВ И.А., ТЮЛЯНДИН С.А. КОМБИНИРОВАННЫЕ РЕЖИМЫ ХИМИОТЕРАПИИ ПРИ РАКЕ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ. Медицинский Совет. 2017;(6):62-70. https://doi.org/10.21518/2079-701X-2017-6-62-70

For citation:


POPOVA A.S., POKATAEV I.A., TYULYANDIN, S.A. COMBINATION CHEMOTHERAPY REGIMENS IN PANCREATIC CANCER. Meditsinskiy sovet = Medical Council. 2017;(6):62-70. (In Russ.) https://doi.org/10.21518/2079-701X-2017-6-62-70

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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)