МЕСТО ЭНЗАЛУТАМИДА В ПОСЛЕДОВАТЕЛЬНОМ ЛЕЧЕНИИ КАСТРАЦИОННО-РЕЗИСТЕНТНОГО РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ
https://doi.org/10.21518/2079-701X-2017-6-104-109
Аннотация
Рак предстательной железы первоначально отвечает на андроген-депривационную терапию, но у большинства пациентов в конечном итоге развивается кастрационно-резистентная форма заболевания. Энзалутамид является суперселективным ингибитором андрогенного рецептора (AР), который блокирует несколько этапов сигнального пути AР. Препарат показал значительную эффективность в лечении метастатического кастрационно-резистентного рака предстательной железы (КРРПЖ) как в 1-й линии терапии, так и во 2-й линии после предшествующей цитотоксической терапии доцетакселом. Чтобы обеспечить оптимальное лечение, важно понять последствия применения энзалутамида в контексте других методов лечения, так как недавние исследования показали, что перекрестная резистентность возникает между классами препаратов и внутри них. Мутации и сплайс-варианты AР также влияют на течение рака предстательной железы. Будущие стратегии лечения, включающие энзалутамид, должны учитывать предшествующий уровень воздействия таксанов или антиандрогенной терапии и наличие вариантов АР, которые могут повлиять на эффективность.
Об авторах
А. А. ГРИЦКЕВИЧ
Институт хирургии им. А.В. Вишневского
Россия
к.м.н.
Россия
к.м.н.
С. В. МИШУГИН
Городская клиническая больница №57
Россия
к.м.н.
Россия
к.м.н.
И. Г. РУСАКОВ
Городская клиническая больница №57
Национальный медицинский исследовательский радиологический центр
Россия
д.м.н., профессор
Россия
д.м.н., профессор
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Рецензия
Для цитирования:
ГРИЦКЕВИЧ АА, МИШУГИН СВ, РУСАКОВ ИГ. МЕСТО ЭНЗАЛУТАМИДА В ПОСЛЕДОВАТЕЛЬНОМ ЛЕЧЕНИИ КАСТРАЦИОННО-РЕЗИСТЕНТНОГО РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ. Медицинский Совет. 2017;(6):104-109. https://doi.org/10.21518/2079-701X-2017-6-104-109
For citation:
GRITSKEVICH AA, MISHUGIN SV, RUSAKOV IG. THE PLACE OF ENZALUTAMIDE IN THE SERIAL TREATMENT OF TREATMENT-RESISTANT PROSTATE CANCER. Meditsinskiy sovet = Medical Council. 2017;(6):104-109. (In Russ.) https://doi.org/10.21518/2079-701X-2017-6-104-109
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