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ФЕБУКСОСТАТ ДЛЯ ЛЕЧЕНИЯ ХРОНИЧЕСКОЙ ГИПЕРУРИКЕМИИ У ПАЦИЕНТОВ, СТРАДАЮЩИХ ПОДАГРОЙ

https://doi.org/10.21518/2079-701X-2017-17-114-122

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Аннотация

Фебуксостат – непуриновый, селективный ингибитор изоформ ксантиноксидоредуктазы, он является альтернативой ограниченному числу лекарственных препаратов для снижения уровня уратов, применяемых в последние десятилетия. Ингибирование ксантиноксидоредуктазы фебуксостатом более  мощно и эффективно, чем аллопуринолом, что подтверждается более частым достижением целевого уровня уратов в сыворотке крови, особенно у пациентов с высокой концентрацией уратов. В отличие от аллопуринола фармакокинетические свойства фебуксостата не зависят в значительной степени от почечного клиренса, что важно для пациентов с хроническими заболеваниями почек. В нескольких исследованиях  проводится дальнейшая оценка  безопасности  фебуксостата для  сердечно-сосудистой системы и его возможного позитивного воздействия на функции почек. Важно и то, что пациентам пожилого возраста не требуется коррекция дозы препарата.

Об авторах

М. С. Петрова
Северо-Западный государственный медицинский университет им. И.И. Мечникова; городская клиническая ревматологическая больница №25 Санкт-Петербурга
Россия

Кандидат медицинских наук



В. И. Мазуров
Северо-Западный государственный медицинский университет им. И.И. Мечникова; городская клиническая ревматологическая больница №25 Санкт-Петербурга
Россия

Академик РАН, доктор медицинских наук, профессор



О. В. Инамова
Северо-Западный государственный медицинский университет им. И.И. Мечникова; городская клиническая ревматологическая больница №25 Санкт-Петербурга
Россия

Кандидат медицинских наук



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ISSN 2079-701X (Print)
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