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Медицинский Совет

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ДАРАТУМУМАБ В ЛЕЧЕНИИ МНОЖЕСТВЕННОЙ МИЕЛОМЫ

https://doi.org/10.21518/2079-701X-2017-14-94-102

Полный текст:

Аннотация

Применение в клинической практике препаратов  из класса ингибиторов протеасом и иммуномодуляторов в последние десятилетия способствовало значительному повышению выживаемости пациентов с множественной миеломой. Вместе с  тем  сохраняется потребность во  внедрении  новых  классов препаратов в  клиническую практику вследствие рецидивирующего течения заболевания. В 2015 г. FDA (США) были  одобрены к применению у пациентов с рецидивирующей множественной миеломой два препарата из класса моноклональных антител, и за короткий период иммунотерапия стала неотъемлемым компонентом лечения таких больных.

В статье представлен анализ данных научных публикаций относительно механизма действия, безопасности применения и клинической эффективности даратумумаба, препарата из класса моноклональных антител, специфичных по отношению к опухолевому белку CD38, при лечении пациентов с множественной миеломой.

В России даратумумаб зарегистрирован (РУ ЛП-004367 от 07.07.2017) и показан в качестве монотерапии у пациентов с    рецидивирующей или  рефрактерной множественной миеломой,  предшествующее лечение  которых включало ингибиторы протеасом и иммуномодулирующие препараты.

Даратумумаб продемонстрировал  благоприятный профиль безопасности. На фоне применения даратумумаба основные нежелательные явления включали  умеренно выраженные реакции, связанные с инфузионным введением препарата, развивавшиеся преимущественно во время первой инфузии.

В настоящее время активно проводится оценка эффективности применения комбинированных схем терапии с включением даратумумаба у пациентов с рецидивирующей и вновь диагностированной миеломой.

Об авторах

В. В. Рыжко
Национальный медицинский исследовательский центр гематологии Минздрава России
Россия

Кандидат медицинских наук.

Москва



М. Л. Канаева
Национальный медицинский исследовательский центр гематологии Минздрава России
Россия

Москва



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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)