Chelation therapy in children
https://doi.org/10.21518/2079-701X-2016-1-123-127
Abstract
Iron overload (RV) is a condition caused by excessive intake of iron, and in the absence of the specific mechanisms for its excretion - excessive accumulation in tissues and their subsequent lesion leading to functional organ failure [1]. This condition most commonly occurs as a result of regular replacement therapy with erythrocyte mass in the treatment of various anemias. According to statistics, about 500 sick children and 2 000 adults develops post-transfusion RV in Russia in every year [2]. It develops in the context of hereditary anemia (major and intermediate forms of beta-thalassemia, other hemoglobinopathies, severe membrane and enzyme defects, congenital sideroblastic and dyserythropoetic anemia, constitutional hypo- and aplastic anemia) or acquired diseases (acquired aplastic anemia, myelodysplastic syndrome (MDS), myelofibrosis, etc.). [3--5].
About the Author
M. V. Krasolnikova
Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology named after D. Rogachev
Russian Federation
Russian Federation
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For citations:
Krasolnikova MV. Chelation therapy in children. Meditsinskiy sovet = Medical Council. 2016;1(1):123-127. (In Russ.) https://doi.org/10.21518/2079-701X-2016-1-123-127
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