TREATMENT OF CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH HYPERTENSION DISEASE: POTENTIAL THERAPEUTIC ROLE OF STATINES
https://doi.org/10.21518/2079-701X-2017-20-26-31
Abstract
The prospective randomized trial included 167 patients with functional class II-III of chronic heart failure (CHF) and a preserved left ventricular ejection fraction (LVEF) affected by hypertensive disease of stage III. In addition to antihypertensive therapy with perindopril and verapamil SR (n = 85) or amlodipine (n = 82), atorvastatin was prescribed, which was regularly taken by 50.6% and 48.8% of patients, respectively. After 12 months, patients in each treatment arm showed improvement in the clinical condition and quality of life, an increase in 6MWD (6-minute walk distance). The patients receiving atorvastatin demonstrated a significant reduction in the N-terminal prohormone of brain natriuretic peptide (NT-proBNP or BNPT) level, and a tendency to improve a diastolic LV function. Adding atorvastatin to the therapy of CHF with preserved LVEF may reasonably improve the prognosis of patients.
About the Authors
S. G. Kanorsky
Kuban State Medical University of the Ministry of Health of Russia.
Russian Federation
Russian Federation
MD, Prof.
Krasnodar.
A. F. Sereda
Kuban State Medical University of the Ministry of Health of Russia.
Russian Federation
Krasnodar.
Russian Federation
Krasnodar.
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Review
For citations:
Kanorsky SG, Sereda AF. TREATMENT OF CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH HYPERTENSION DISEASE: POTENTIAL THERAPEUTIC ROLE OF STATINES. Meditsinskiy sovet = Medical Council. 2017;(20):26-31. (In Russ.) https://doi.org/10.21518/2079-701X-2017-20-26-31
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