MONO- OR COMBINED ANTIHYPERTENSIVE THERAPY IN WOMEN WITH ARTERIAL HYPERTENSION AND MODERATE RISK OF CARDIOVASCULAR DISEASES: WHAT’S BETTER?
https://doi.org/10.21518/2079-701X-2017-20-40-44
Abstract
The study included 75 women with arterial hypertension, aged 48-51 years (Me 50,0 years [25%; 75%: 48,0; 52,0 years]), who according to the clinical laboratory and instrumental examination was diagnosed essential hypertension (EH) I–II stage of 1–2 degrees. The duration of arterial hypertension did not exceed 5 years (Me 1 year [25%; 75%: 1; 3 years]) and all women had moderate risk of cardiovascular complications on the SCORE scale. All patients were in the perimenopausal period, confirmed by laboratory of hormonal status. After 14 weeks of monotherapy losartan or ramipril or combination with one of RAAS blockers and bisoprolol with low-dose hydrochlorothiazide was achieved target blood pressure and improvement of endothelial and kidney function, which was manifested by decrease in the level of albuminuria and ADMA concentration, significantly exceeding the reference values in the initial state. More pronounced organoprotective effect was in the group of women, receiving combined antihypertensive therapy.
About the Authors
R. I. Stryuk
Evdokimov Moscow State Medical and Stomatologic University of the Ministry of Health of Russia.
Russian Federation
Russian Federation
MD, Prof.
Moscow.
Y. V. Brytkova
Evdokimov Moscow State Medical and Stomatologic University of the Ministry of Health of Russia.
Russian Federation
Russian Federation
MD.
Moscow.
O. V. Tatarinova
Evdokimov Moscow State Medical and Stomatologic University of the Ministry of Health of Russia.
Russian Federation
Moscow.
Russian Federation
Moscow.
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Review
For citations:
Stryuk RI, Brytkova YV, Tatarinova OV. MONO- OR COMBINED ANTIHYPERTENSIVE THERAPY IN WOMEN WITH ARTERIAL HYPERTENSION AND MODERATE RISK OF CARDIOVASCULAR DISEASES: WHAT’S BETTER? Meditsinskiy sovet = Medical Council. 2017;(20):40-44. (In Russ.) https://doi.org/10.21518/2079-701X-2017-20-40-44
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