THE RESULTS OF THE USE OF 5-AMINOSALICYLIC ACID AS AN ANTI-RELAPSE AND MAINTENANCE THERAPY ULCERATIVE COLITIS MODERATE SEVERITY IN CLINICAL PRACTICE
https://doi.org/10.21518/2079-701X-2017-20-108-117
Abstract
Ulcerative colitis (UC) is a chronic disease characterized by immune diffuse inflammation of the mucosa of the colon with mandatory involvement in the inflammatory process of the rectum. The choice of conservative or surgical treatment depends upon the severity of the attack, extent of lesions of the colon, presence of extraintestinal manifestations, duration of disease, efficacy and safety of past therapy and the risk of complications UC. In Russia and abroad for the treatment and prevention of relapses of UC are widely used mesalazine having minimum side effects. Our study shows high adherence of patients to receive drugs 5-ASA and the positive impact of the use of oral medications 5-ASA Salofalk and Asacol for the maintenance of remission in patients UC moderate severity in clinical practice. This study also showed the importance of long-term use (at least 12 months) drugs 5-ASA to maintain remission and reduce the risk of disease recurrence.
About the Authors
O. V. Knyazev
Loginov Moscow Clinical Scientific Center of the Moscow Department of Healthcare.
Russian Federation
Russian Federation
MD.
Moscow.
A. V. Kagramanova
Loginov Moscow Clinical Scientific Center of the Moscow Department of Healthcare.
Russian Federation
Russian Federation
PhD in medicine.
Moscow.
References
1. Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epi demiology and natural history of inflammatory bowel diseases. Gastroenterology, 2011, 140: 1785-94.
2. Белоусова Е.А., Никитина Н.В., Цодикова О.М. Лечение язвенного колита легкого и среднетяжелого течения. Фарматека, 2013, 2: 42–46.
3. Халиф И.Л. Лечебная тактика при язвенном колите. Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2006, 16(3): 58–62.
4. Халиф И.Л. Принципы лечения язвенного колита (рекомендации российской группы по изучению воспалительных заболеваний кишечника). Колопроктология, 2006, 2: 31–33.
5. Dignass A, Lindsay JO, Sturm A et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management. Journal of Crohn’s and Colitis, 2012, 6: 991-1030. doi: 10.1016/j.crohns.2012.09.002.
6. Langholz E, Munkholm P, Davidsen M, Binder V. Course of ulcerative colitis: analysis of changes in disease activity over years. Gastroenterology, 1994, 107: 3–11.
7. Michelassi F, Fichera A, Kirshner JB (Еd.). Inflamma tory Bowel Disease. 5-th ed. Philadelphia, 2000: 616–626.
8. Воробьев Г.И., Халиф И.Л. Неспецифические воспалительные заболевания кишечника. М.: Миклош, 2008. 400 c.
9. Travis SP, Stange EF, Lemann M et al: European evidence-based consensus on the management of ulcerative colitis: current management. J Crohns Colitis, 2008, 2: 24–62.
10. Ford AC, Achkar JP, Khan KJ et al. Effecacy of 5-aminosalicylates in ulcer-ative colitis: systematic review and meta-analysis. Am J Gastroenterol, 2011, 106: 601–16.
11. Ham M, Moss AC. Mesalamine in the treatment and maintenance of remission of ulcerative colitis. Expert Rev Clin Pharmacol, 2012, 5: 113–23.
12. Ивашкин В.Т., Шелыгин Ю.А., Халиф И.Л. [и др.]. Клинические рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению язвенного колита. Колопроктология. 2017, 1(59): 6-30.
13. Wang Y, Parker CE, Feagan BG, MacDonald JK. Oral 5-Aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev, 2016, 9: CD000544.
14. Kruis W, Jonaitis L, Pokrotnieks J, Mikhailova TL, Horynski M, Bátovský M, et al. Randomised clinical trial: a comparative dose-finding study of three arms of dual release mesalazine for maintaining remission in ulcerative colitis. Aliment Pharmacol Ther, 2011, 33: 313–22.
15. Masakazu Nagahori, Shuji Kochi, Hiroyuki Hanai, Takayuki Yamamoto, Shiro Nakamura, Soji Omuro, Mamoru Watanabe, Toshifumi Hibi. Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multicenter study, OPTIMUM Study. BMC Gastroenterol, 2017 Apr 4, 17(1): 47. doi: 10.1186/s12876-017-0604-y.
16. Dignass AU, Bokemeyer B, Adamek H, Mross M, Vinter-Jensen L, Börner N, et al. Mesalamine once daily is more effective than twice daily in patients with quiescent ulcerative colitis. Clin Gastroenterol Hepatol, 2009, 7: 762–9.
17. D’Haens G, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology, 2007, 132 (2): 763–86.
18. Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med, 1987, 317(26): 1625–9.
19. Ito H, Iida M, Matsumoto T, Suzuki Y, Aida Y, Yoshida T, et al. Direct comparison of two different mesalamine formulations for the maintenance of remission in patients with ulcerative colitis: a double-blind, randomized study. Inflamm Bowel Dis, 2010, 16: 1575–82.
Review
For citations:
Knyazev OV, Kagramanova AV. THE RESULTS OF THE USE OF 5-AMINOSALICYLIC ACID AS AN ANTI-RELAPSE AND MAINTENANCE THERAPY ULCERATIVE COLITIS MODERATE SEVERITY IN CLINICAL PRACTICE. Meditsinskiy sovet = Medical Council. 2017;(20):108-117. (In Russ.) https://doi.org/10.21518/2079-701X-2017-20-108-117
Views:
638
Email this article 