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Афатиниб: новые возможности терапии рака легкого с наличием активирующих мутаций EGFR

https://doi.org/10.21518/2079-701X-2015-8-50-54

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Аннотация

Применение ингибиторов EGFR первого поколения существенно улучшило результаты лекарственного лечения пациентов с метастатическим немелкоклеточным раком легкого, включая значимое увеличение частоты достижения объективного эффекта и времени до прогрессирования болезни. В настоящее время арсенал эффективных препаратов расширился за счет внедрения в клиническую практику ингибитора EGFR второго поколения - афатиниба. По данным клинических исследований, максимальная реализация его лечебного эффекта зависит не только от статуса активирующей мутации, но и от ее типа. При наличии мутации EGFr в 19 экзоне афатиниб значимо увеличивает и медиану общей выживаемости. Это представляется чрезвычайно важным обстоятельством, определяющим выбор рационального лечения. Афатиниб эффективен также при развитии резистентности к ингибиторам EGFR первого поколения и представляет собой альтернативный вариант второй линии терапии. Трудно переоценить данное преимущество препарата, позволяющее существенно отсрочить назначение химиотерапии таким больным.

Об авторах

М. В. Степанченко
Российский онкологический научный центр им. Н.Н. Блохина, Москва
Россия


В. Г. Зайцев
Российский онкологический научный центр им. Н.Н. Блохина, Москва
Россия


С. Л. Гуторов
Российский онкологический научный центр им. Н.Н. Блохина, Москва
Россия


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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)