Preview

Meditsinskiy sovet = Medical Council

Advanced search

Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency

https://doi.org/10.21518/2079-701X-2018-4-90-99

Abstract

A well-known crucial role of Vitamin D is in the maintenance of musculoskeletal system. In terms of high prevalence of violations of calcium-phosphorus metabolism, in the following article we will touch upon some aspects bone metabolic dysfunction, caused by Vitamin D deficiency. Moreover, recent researches reveal that the great amount of Vitamin D and their importance lead us to calling it a global regulator of homeostasis of human body, so below we are to analyze and generalize the pleiotropic effects of Vitamin D, concerning its influence on organs and systems of organs. Also in this article we bring up the results of some researches, which have persuasively demonstrated that the optimal level of Vitamin D in blood has a positive effects on a humans health and protects it from many more diseases of civilization. Futhermore, there are going to be regarded various methods for medication correction of vitamin D deficiency, and one clinical case of an inadequate diagnosis and treatment of hypovitaminosis D.

About the Authors

V. V. Salukhov
S.M. Kirov Military Medical Academy
Russian Federation

MD, Prof. 

St.Peteburg



E. A. Kovalevskaya
S.M. Kirov Military Medical Academy
Russian Federation
St.Peteburg


V. V. Kurbanova
S.M. Kirov Military Medical Academy
Russian Federation
St.Peteburg


References

1. Shvarts GYa. Vitamin D renaissance: molecular biological, physiological and pharmacological aspects. Meditsinskiy sovet, 2015, 18: 102-110.

2. Wierzbicka J, Piotrowska A, Żmijewski MA. The renaissance of vitamin D. Acta Biochim Pol, 2014, 61(4): 679-86.

3. Richard А, Sabine R, Katharina C. Prevalence of Vitamin D Deficiency and Its Associations with Skin Color in Pregnant Women in the First Trimester in a Sample from Switzerland. Quack Lötscher Nutrients, 2017, 9: 2-11.

4. Chunfeng Yun, Jing Chen, Yuna He, Deqian Mao, Rui Wang, Yu Zhang et al. Vitamin D deficiency prevalence and risk factors among pregnant Chinese women. Public Health Nutrition, 2015, 20(10): 1746-1754.

5. Thi Mai, Alexandrova VA, Churilov LP. Vitamin D deficiency in the tropics and subtropics. Krymskiy Zhurnal Eksperimentalnoy i Klinicheskoy Meditsiny, 2017, 7 (1): 80-88.

6. Hewison M. Vitamin D and the intracrinology of innate immunity. Mol. Cell. Endocrinol., 2010, 321(2): 103–111.

7. Nettore IC, Albano L, Ungaro P, Colao A, Macchia PE. Sunshine vitamin and thyroid. Rev. Endocr. Metab. Disod., 2017. Epub. ahead of print. DOI 10.1007/s11154-017-9406-3.

8. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int, 2009 Nov, 20(11): 1821.

9. El-Hajj Fuleihan G Vitamin D deficiency in the Middle East and its health consequences. Clin Rev Bone Miner Metab, 2009, 7: 77–79.

10. Vitebskaya AV, Smirnova GE, Ilyin AV. Vitamin D and calcium-phosphorus metabolism in children living in the middle zone of Russia during the maximum insolation period. Osteoporoz i Osteopatii, 2010, 2: 2-6

11. Pigarova E, Plescheva A, Dzeranova L. Changes in physical function in patients with chronic fatigue syndrome treated with vitamin D. ENDO 2013, San Francisco. 15-18 June 2013.

12. Markova TN, Markov DS, Markelova TN, Nigmatullina SR, Baimkina EV, Borisova LV, et al. The prevalence of vitamin D deficiency and osteoporosis risk factors in young people. Vestnik Chuvashskogo Universiteta, 2012, 3: 441-446.

13. Verbova AF, Sharonova LA, Kapishnikov AV, Demidova DV Vitamin D3, osteoprotegerin and other hormone-metabolic parameters in women with type 2 diabetes mellitus. Obesity and Metabolism, 2012, 4: 23-27.

14. Drygin, LB, Dorofeychik-Drygin NA, Prokhorova OV. Vitamin D status in the development of osteodeficiency in EMERCOM firefighters of Russia. Mediko-biologicheskiye i Sotsialnopsikhologicheskiye Problemy Bezopasnosti v Chrezvychaynykh Situatsiyakh, 2013, 3: 5-9.

15. Clinical guidelines. Vitamin D deficiency in adults: diagnosis, treatment, prevention. M., 2015.

16. Дедов И.И., Мельниченко Г.А. Российские клинические рекомендации. Эндокринология. М.: ГЭОТАР-Медиа, 2016./ Dedov II, Melnichenko GA. Russian clinical guidelines. Endocrinology. Moscow: GEOTAR-Media, 2016.

17. Kodentsova VM, Mendel OI, Khotimchenko SA. Physiological needs and effective doses of vitamin D to correct its deficiency. Status update on the problem. Voprosy Pitaniya, 2017, 86 (2): 47-62.

18. Strukov VI. Osteomed is an effective regulator of bone mineral density and closure of cavities in the treatment of presenile and senile osteoporosis. Polyklinika, 2013, 1 (1): 90-91.

19. Reusheva SV, Panicheva EA, Pastukhova S.Yu., Reushev MYu. Role of vitamin D deficiency in human diseases and disorders. Uspekhi Sovremennogo Estestvoznaniya, 2013, 11: 27-28.

20. Domenyuk DA, Davydov BN, Vedeshina EG, Dmitrienko SV. Change in markers of bone tissue metabolism in blood serum and oral fluid in patients with malocclusions. Klinicheskaya Stomatologiya, 2015,4: 72-75.

21. Erofeev NP, Pariyskaya EN. Physiology of the endocrine system. SPb.: SpetsLit, 2013.

22. Belaya ZhE, Belova KYu, Bordakova EV, Gilmanov AZh, Gurkina EYu. Osteoporosis: treatment and prevention. Vitamin D in the therapy of osteoporosis: its role in combination with drugs for the treatment of osteoporosis, extra-skeletal events. Effektivnaya Farmakoterapiya, 2013, 38: 15.

23. Ershova OB, Belova KYu, Nazarova AV. Calcium and vitamin D: how much we know about them? RMJ, 2011, 12 (19): 720-722.

24. Maltsev SV, Mansurova GSh. Vitamin D metabolism and ways of implementation of its basic functions. Practicheskaya Medicina, 2014, 9: 12-18.

25. Gromova OA, Troshin IYu, Spirichev VB. Genome-wide view of vitamin D receptor binding sites. Meditsinskiy Sovet, 2016, 1: 12-21.

26. Llewellyn DJ, Langa KM, Lang IA. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J. Geriatr. Psychiatry Neurol., 2009, 22(3): 188–195.

27. Lee DM, Tajar A, Ulubaev A, Pendelton N, O’Neill TW, O’Connor DB. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J. Neurol. Neurosurg. Psychiatry, 2009, 80: 722–729.

28. Gromova OA, Torshin IYu, Pronin AV. Vitamin D neurosteroid effects. The role in pediatrics. Pharmateka, 2015, 11: 12-21.

29. Kvashnina LV. Immunomodulatory effects of vitamin D in children. Zdorovye Rebenka, 2013, 7 (50): 134-138.

30. Pigarova EA, Pleshcheva AV, Dzeranova LK. Vitamin D impact on the immune system. Immunologiya, 2015, 1: 62-66.

31. Wacker M, Holick MF. Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients, 2013, 5(1): 111148.

32. Gromova OA, Troshin IYu. Physiological model of link between vitamin D3 and cancer: evidence-based medicine data. All-Russian journal for physicians of all specialties. Terre Medic Nova, 2009, 2: 42.

33. Grant WB. Ecological studies of the UVBvitamin D-cancer hypothesis. Anticancer. Res., 2012, 32(1): 223-236.

34. Pilz S, Tomaschitz A, Obermayer-Pietsch B. Epidemiology of vitamin D insufficiency and cancer mortality. Anticancer. Res., 2009, 29(9): 3699-3704.

35. Wolden-Kirk H, Overbergh L, Christesen HT. Brusgaard K, Mathieu C.Vitamin D and diabetes: its importance for beta cell and immune function. Mol. Cell. Endocrinol., 2011, 347(1-2): 106-120.

36. Karonova TL, Mikheeva EP, Krasilnikova EI, Belyaeva OD, Budanova MV, Galkina OV, et al. Vitamin D deficiency is a risk factor for the development of obesity and type 2 diabetes in women of reproductive age. Arterialnaya Gipertenziya, 2012, 1 (18): 27.

37. Dutta D, Maisnam I, Shrivastava A, Sinha A, Ghosh S, Mukhopadhyay P, et al. Serum vitamin-D predicts insulin resistance in individuals with prediabetes. Indian. J. Med. Res., 2013, 138(6): 853-860.

38. Al-Daghri NM, Sabico S, Al-Saleh Y, Aljohani N, Sulimani R, AlOthman AM, et al. Calculated adiposity and lipid indices in healthy Arab children as influenced by vitamin D status. J Clin Lipidol., 2016, 10: 775-781.

39. Pereira-Santos M, Costa PR, Santos CA, Santos DB, Assis AM. Obesity and vitamin D deficiency: Is there an association? Obes Rev., 2016, 17: 484.

40. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care, 2013, 36: 260-266.

41. Beilfuss J, Berg V, Sneve M, Jorde R, Kamycheva E. Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects. Cytokine, 2012, 60: 870-874.

42. Sun Q., An Pan, Frank B. Hu, JoAnn E. Manson, Kathryn M. 25-Hydroxyvitamin D levels and the risk of stroke: a prospective study and metaanalysis. Stroke, 2012, 43(6): 1470-1477.

43. Bhandari SK, Pashayan S, Liu IL. 25-hydroxyvitamin D levels and hypertension rates. J. Clin. Hypertens. (Greenwich), 2011, 13(3): 170-177.

44. Forman JP, Jamil B Scott, Kimmie Ng, Bettina F Drake, Elizabeth Gonzalez Suarez, Douglas L Hayden at al. Effect of vitamin D supplementation on blood pressure in blacks. Hypertension, 2013, 61(4): 779-785.

45. Povoroznyuk VV, Snezhitsky VA, Yankovskaya LV, Mailian EA, Reznichenko NA, Mailan DE. The role of vitamin D in the in pathogenesis of cardiovascular diseases. Zhurnal Grodnenskogo Gosudarstvennogo Meditsinskogo Universiteta, 2015, 2: 6-14.

46. Tishkoff DX, Nibbelink KA, Holmberg KH, Dandu L, Simpson RU. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout Cardiomyocyte contractility. Endocrinology, 2008, 149: 558-564.

47. Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, et al. Effect of Vitamin D supplementation on blood pressure: A systematic review and meta-analysis incorporating individual. Patient data. JAMA Intern Med, 2015, 175: 745-754.

48. Li YC. Discovery of vitamin D hormone as a negative regulator of the renin-angiotensin system. Clin. Chem, 2014, 60(3): 561-562.

49. Jiang P, Zhang WY, Li HD, Cai HL, Liu YP, Chen LY. Stress and vitamin D: Altered vitamin D metabolism in both the hippocampus and myocardium of chronic unpredictablemild stress exposed rats. Psychoneuroendocrinology, 2013, 38: 2091-2098.

50. Abdi-Ali A, Nicholl DD, Hemmelgarn BR, MacRae JM, Sola DY, Ahmed SB. 25-hydroxyvitamin D status, arterial stiffness and the reninangiotensin system in healthy humans. Clin Exp Hypertens, 2014, 36: 386-391.

51. Zhang W, Chen L, Zhang L, Xiao M, Ding J, Goltzman D, et al. Administration of exogenous 1,25(OH)2D3 normalizes over activation of the central renin-angiotensin system in 1α(OH) ase knockout mice. Neurosci Lett, 2015, 588: 184-189.

52. Akbas EM, Gungor A, Ozcicek A, Akbas N, Askin S, Polat M. Vitamin D and inflammation: Evaluation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Arch Med Sci, 2016, 12: 721-727.

53. Azizieh F, Alyahya KO, Raghupathy R. Association between levels of vitamin D and inflammatory markers in healthy women. J Inflamm Res, 2016, 9: 51-57.

54. Srikanth P, Chun RF, Hewison M, Jacobs J, Wang Y, Jones KS, et al. Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men. Osteoporos Int, 2016, 27: 2291-300.

55. Sogomonian R, Alkhawam H, Jolly J, Vyas N, Ahmad S, Haftevani EM, et al. Serum vitamin D levels correlate to coronary artery disease severity: A retrospective chartanalysis. Expert Rev Cardiovasc Ther, 2016, 14: 977-982.

56. Chen WR, Liu ZY, Shi Y, Yin DW, Wang H, Sha Y, et al. Relation of low vitamin D to nonvalvular persistent atrial fibrillation in Chinese patients. Ann Noninvasive Electrocardiol, 2014, 19: 166-173.

57. Ugay LG, Kochetkova EA, Nevzorova VA. Vitamin D and respiratory diseases: molecular and clinical implications. Dalnevostochnyy Meditsinskiy Zhurnal, 2012, 3: 116-118

58. Nobili V, Giorgio V, Liccardo D. Vitamin D levels andliver histological alterations in children with nonalcoholic fatty liver disease. Eur. J. Endocrinol., 2014, 170: 547–553.

59. Barchetta I, Angelico F, Del Ben M. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med, 2011, 9: 85.

60. Zhai HL, Wang NJ, Han B, Li Q, Chen Y, Zhu CF, et al. Low vitamin D levels and non-alcoholic fatty liver disease, evidence for their independent association inmen in East China: A crosssectional study (Survey on Prevalence in East China for Metabolic Diseases andRisk Factors (SPECT-China)). Br. J. Nutr., 2016, 115: 1352–1359.

61. Beilfuss A, Sowa JP, Sydor S, Beste M, Bechmann LP, Schlattjan M, et al. Vitamin D counteracts fibrogenic TGF-beta signaling in human hepatic stellatecells both receptordependently and independently. Gut, 2015, 64: 791-799.

62. Abramovitch S, Sharvit E, Weisman Y, Bentov, A., Brazowski, E., Cohen, G.at al. Vitamin D inhibits development of liver fibrosis in an animal model but cannot ameliorate established cirrhosis. Am. J. Physiol. Gastrointest. Liver Physiol., 2015, 308: 112–120.

63. Kitson M.T, Pham A, Gordon A, Kemp W, Roberts SK. High-dose vitamin D supplementation and liver histology in NASH. Gut, 2016, 65: 717–718.

64. Sharifi N, Amani R, Hajiani E, Cheraghian B. Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical rial. Endocrine, 2014, 47: 70–80.

65. Lorvand Amiri H, Agah S, Tolouei Azar J, Hosseini S, Shidfar F, Mousavi SN. Effect of daily alcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energyrestricted diet: Randomized, controlled, doubleblind trial. Clin. Nutr., 2016, 1: 112-113.

66. Manco M, Ciampalini P, Nobili V. Low levels of 25-hydroxyvitamin D (3) in children with biopsy-provennonalcoholic fatty liver disease. Hepatology, 2010, 51: 2229.

67. Luger M, Kruschitz R, Kienbacher C. Prevalence of Liver Fibrosis and its Association with Noninvasive Fibrosis andMetabolic Markers in Morbidly Obese Patients with Vitamin D Deficiency. Obes. Surg., 2016, 26: 2425–2432.

68. Tyuzikov IA, Kalinchenko SYu, Vorslov LO. Vitamin D, men’s health and male reproduction. Andrologiya i Genitalnaya Khirurgiya, 2013, 4: 36-42.

69. Maltseva LI, Vasilyeva EN. New approaches to assessment of the role of vitamin D in women’s reproductive health. Prakticheskaya Meditsina, 2013, 7 (76): 42-46.

70. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, at al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011, 96(7): 1911-1930.

71. Holick MF. Vitamin D deficiency. N Engl J Med, 2007, 3(57): 266-281.

72. Maltseva LI, Vasilyeva EN, Denisova TG, Gerasimova LI. Vitamin D status and correction of its deficiency during pregnancy. Prakticheskaya Meditsina, 2017, 5 (106): 18-21.

73. Belaya ZhE, Rozhinskaya LYa. Vitamin D therapy of osteoporosis: its role in combination therapy of osteoporosis, extra-skeletal effects. Effektivnaya Farmakoterapiya, 2013, 2: 14-29.

74. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press, 2010.


Review

For citations:


Salukhov VV, Kovalevskaya EA, Kurbanova VV. Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency. Meditsinskiy sovet = Medical Council. 2018;(4):90-99. (In Russ.) https://doi.org/10.21518/2079-701X-2018-4-90-99

Views: 1805


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)