Clinical and functional features of thyroid gland dysfunction combined with metabolic syndrome
https://doi.org/10.21518/2079-701X-2018-4-100-104
Abstract
The associations or relationship of MetS and its components with thyroid gland (TG) dysfunction are well known, and the study was aimed at establishing the clinical and functional features of the thyroid gland dysfunction combined with the metabolic syndrome. The study included 90 patients aged 18 years and older with the presence of comorbidities which included metabolic syndrome and thyroid diseases (MetS and TG); with MetS without TG dysfunction and with TG dysfunction without MetS. A comparative assessment of BMI, insulin, HOMA-IR index, lipid profile values was carried out in the studied subgroups of patients depending on the functional state of the thyroid gland. The study showed that the comorbid course of subcompensated hypothyroidism and MetS is associated with aggravation of hyperinsulinemia and insulin resistance, with a tendency towards an increase in BMI, an unfavourable shift in lipid metabolism.
About the Authors
A. A. Fateevа
Sechenov First Moscow State Medical University of the Ministry of Health of Russia;
Asfendiyarov Kazakh National Medical University
Russian Federation
Moscow, Alma-Ata
Russian Federation
Moscow, Alma-Ata
N. A. Martirosyan
Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
PhD in medicine
Moscow
N. A. Petunina
Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
MD, Prof.
Moscow
References
1. Lazebnik LB. Aging and polymorbidity. Consilium Medicum, 2005, 12: 993-996.
2. Belyalov FI. The impact of comorbidity on management of internal diseases. Monograph. 2nd ed., Irkutsk, 2010.
3. van den Akker M, Buntinx F, Metsemakers JF, Roos S, Knottnerus JA. Multimorbidity in general practice:prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. J Clin Epidemiol, 1998, 51: 367-375.
4. Reaven GM. Insulin resistance, compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease. J. Clin. Endocrinol. Metab., 2003, 38(6): 2399-2403.
5. Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E. Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocrine Journal, 2006, 53: 653–657.
6. Shantha GP, Kumar AA, Jeyachandran V, et al. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a crosssectional study from South India. Thyroid Res, 2009, 2(1):1-7.
7. Chaker L, Ligthart S, Korevaar TIM, et al. Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study. BMC Medicine, 2016, 14: 150.
Review
For citations:
Fateevа AA, Martirosyan NA, Petunina NA. Clinical and functional features of thyroid gland dysfunction combined with metabolic syndrome. Meditsinskiy sovet = Medical Council. 2018;(4):100-104. (In Russ.) https://doi.org/10.21518/2079-701X-2018-4-100-104
Views:
690
Email this article 