Not fully informed possibilities for prevention of atherosclerosis
https://doi.org/10.21518/2079-701X-2018-5-26-32
Abstract
The article discusses new opportunities for reducing the risk of complications of cardiovascular diseases caused by atherosclerosis in a wide range of people for the purposes of primary and secondary prevention. The article provides for the data of the most important clinical studies, both randomized and observational, which can become the basis for revising the target and threshold blood levels of low-density lipoprotein (LDL) cholesterol (CS) in the near future. In addition, the rational for the wider use of combination drugs containing statins and antiplatelet agents is considered to increase adherence to therapy in conditions of induced polypharmacotherapy in a wide range of patients with cardiovascular diseases. In recent years, lipid-lowering therapy has got two main trends: 1) determining the lipid levels in the blood, and especially lowdensity lipoprotein (LDL) cholesterol, which stops progression or regression of atherosclerosis; 2) obtaining evidence on improvement of the prognosis for patients with cardiovascular diseases caused by atherosclerosis (CVDCA), with a decrease in the concentration of LDL-C in the blood to lower levels compared with those that were previously accepted. In this article, we wanted to recall the results of the most important studies that reflect these modern trends in lipidology.
About the Authors
S. R. Gilyarevsky
Russian Medical Academy of Continuing Postgraduate Education of the Ministry of Health of Russia, Moscow
Russian Federation
Russian Federation
MD, Prof.
M. V. Golshmid
Russian Medical Academy of Continuing Postgraduate Education of the Ministry of Health of Russia, Moscow
Russian Federation
PhD in medicine
Russian Federation
PhD in medicine
I. M. Kuzmina
Sklifosofsky Research Institute for Emergency Care, Moscow
Russian Federation
PhD in medicine
Russian Federation
PhD in medicine
N. G. Bendiliani
Bakulev National Medical Research Centre for Cardiovascular Surgery of the Ministry of Health of Russia, Moscow
Russian Federation
MD
Russian Federation
MD
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Review
For citations:
Gilyarevsky SR, Golshmid MV, Kuzmina IM, Bendiliani NG. Not fully informed possibilities for prevention of atherosclerosis. Meditsinskiy sovet = Medical Council. 2018;(5):26-32. (In Russ.) https://doi.org/10.21518/2079-701X-2018-5-26-32
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