What can apply for the role of basic therapy for chronic pain in comorbid patients?
https://doi.org/10.21518/2079-701X-2018-6-120-126
Abstract
Chronic pain in joints and back is almost constant component of the comorbidities. The comorbidities are caused by the systemic inflammation syndrome, which activity affects the degree of pathology mediating the progression of chronic pain as well. The pathogenesis pattern of systemic inflammation differs in having the whole range of transcriptional proteins, which activity is associated with the level of synthesis of pro-inflammatory mediators. Many recent studies showed that vitamin D3 deficiency and insufficiency increases the activity of these transcriptional proteins, increasing the progression and intensity of comorbidity components, including pain syndrome. Fundamental research demonstrates anti-inflammatory and anti-erosive vitamin D3 effects in cartilage and bone tissue.
About the Authors
A. V. Naumov
Pirogov Russian National Research Medical University of the Ministry of Health of Russia, a separate structural subdivision – Russian Gerontological Research and Clinical Center, Moscow
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
O. N. Tkacheva
Pirogov Russian National Research Medical University of the Ministry of Health of Russia, a separate structural subdivision – Russian Gerontological Research and Clinical Center, Moscow
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
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Review
For citations:
Naumov AV, Tkacheva ON. What can apply for the role of basic therapy for chronic pain in comorbid patients? Meditsinskiy sovet = Medical Council. 2018;(6):120-126. (In Russ.) https://doi.org/10.21518/2079-701X-2018-6-120-126
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