Preview

Meditsinskiy sovet = Medical Council

Advanced search

Chronic endometritis and habitual miscarriage

https://doi.org/10.21518/2079-701X-2018-7-46-49

Abstract

Objective of the study: analysis of the data presented in the modern literature on the relationships between chronic endometritis (CE) and miscarriage. Material and methods: the review includes data from foreign and domestic studies published in the electronic databases Medline, Pubmed over the past 15 years. Results: this review analysed the data on the diagnosis of CE, and pathophysiological processes leading to habitual miscarriage. It also showed the role of the microbial factor, the level of cytokines, leptins, expression of metalloproteinases, immune factor, dysbiotic disturbances of vaginal microflora.

About the Authors

I. B. Manukhin,
A.I. Yevdokimov Moscow State University of Medicine and Dentistry А.И. of the Ministry of Health of Russia
Russian Federation
MD, Prof.


N. A. Sementsova
A.I. Yevdokimov Moscow State University of Medicine and Dentistry А.И. of the Ministry of Health of Russia
Russian Federation
PhD in medicine


Yu. Yu. Mitrofanova
A.I. Yevdokimov Moscow State University of Medicine and Dentistry А.И. of the Ministry of Health of Russia
Russian Federation


L. Yu. Livshits
A.I. Yevdokimov Moscow State University of Medicine and Dentistry А.И. of the Ministry of Health of Russia
Russian Federation


References

1. Kulakov VI. Reproductive health of the population of Russia. Akusherstvo i Ginekologiya, 2002, 2: 4-7.

2. Sidelnikova VM, Sukhikh GT. Habitual miscarriage. M., 2010. 534 p.

3. Early pregnancy (2nd ed., Edited by Radzinsky VE, Orazmuradova AA. M: Status praesens, 2009. 480 p.

4. Carp HJ. Intravenous immunoglobulin: effect on infertility and recurrent pregnancy loss. Isr. Med. Assoc. J., 2007, 9(12): 877-880.

5. Sementsova NA. Clinical and morphological aspects of early reproductive losses. Diss. of PhD in medicine. M., 2013

6. Johnston-MacAnanny EB, Hartnett J et al. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil Steril, 2010, 93: 437-441.

7. Fatemi HM, Popovic-Todorovic B et al. In vitro fertilization pregnancy in a patient with proven chronic endometritis. Fertil Steril, 2009, Apr: 9-11.

8. Plyasunova MP, Khlybova SV. Chronic endometritis as one of the actual problems in modern gynecology. Vyatskiy Meditsinskiy Vestnik, 2013, 1.

9. Cicinelli E, De Ziegler D, Nicoletti R, Colafiglio G, Saliani N, Resta L, Rizzi D, De Vito D. Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertil Steril, 2008 Mar, 89(3).

10. Cicinelli E, Matteo M, Tinelli R, Pinto V, Marinaccio M, Indraccolo U, De Ziegler D, Resta L. Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment. Reprod Sci, 2014 May, 21(5).

11. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF III, Petraglia F. Inflammation and pregnancy. Reproductive Sciences, 2009, 16: 206-215.

12. Wang H & Dey SK. Road map to embryo implantation: clues from mouse models. Nature Reviews. Genetics, 2006, 7: 185-199.

13. Kelly RW, King AE & Critchley HO. Cytokine control in human endometrium. Reproduction, 2001, 121: 3–19.

14. Renaud SJ & Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunological Investigations, 2008, 37: 535-564.

15. Nissi R, Talvensaari-Mattila A, Kotila V, Niinimäki M, Järvelä I, Turpeenniemi-Hujanen T. Circulating matrix metalloproteinase MMP-9 and MMP-2/ TIMP-2 complex are associated with spontaneous early pregnancy failure. Reprod Biol Endocrinol, 2013 Jan 15.

16. Ross JDC. What is endometritis and does it require treatment? Sex Transm Infect, 2004 Aug.

17. Kovalenko VL, Kazachkov EL, Voropaeva EE, Kazachkova EA. The characteristics of the epithelium and endometrial extracellular matrix in miscarriage during early pregnancy associated with chronic endometritis. Arkh Patol, 2009 Sep-Oct.

18. Galgani M, Insabato L, Calì G, Della Gatta AN, Mirra P, Papaccio F, Santopaolo M, Alviggi C, Mollo A, Strina I, Matarese G, Beguinot F, De Placido G, Ulianich L. Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity. Fertil Steril, 2015 Jun.

19. Lea RG, Oliver SS. Immunoendocrine aspects of endometrial function and implantation. Reproduction, 2007, 134(3): 389-404.

20. Szekeres-Bartho J, Balasch J. Progestagen therapy for recurrent miscarriage. Hum. Reprod. Update, 2008, 14(1): 27-35.

21. Marinkin IO, Nepomnyashchikh DL, Kuleshov VM, Ilizarova NA, Semchenko TO, Aidagulova SV. Ultrastructural research of the endometrium receptivity in conditions of pre-conceptional preparation in habitual miscarriage. Byulleten SO RAMN, 2014, 34 (2): 29-33.

22. Tan Y, Xu Q, Li Y, Mao X, Zhang K. Crosstalk between the p38 and TGF-β signaling pathways through TβRI, TβRII and Smad3 expression in plancental choriocarcinoma JEG-3 cells. Oncol Lett, 2014 Sep, 8(3): 1307-1311.

23. Hadinedoushan H, Abbasirad N, Aflatoonian A, Eslami G. The serum level of transforming growth factor beta1 and its association with Foxp3 gene polymorphism in Iranian women with recurrent spontaneous abortion. Hum Fertil (Camb), 2015 Mar, 18(1): 54-59.

24. Danusevich IN, Kozlova LS, Suturina LV, Ilyin VP, Beketova IS. The state of the main components of the immune system in women with reproductive disorders against the background of chronic endometritis and in its absence. Byulleten Vostochno-Sibirskogo Nauchnogo Tsentra Sibirskogo Otdeleniya Rossiyskoy Akademii Meditsinskikh Nauk, 2012, 3: 72-74.

25. Gao Y, Wang PL. Increased CD56(+) NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion. Genet Mol Res, 2015 Dec 22, 14(4).

26. Kolesnikova LI, Danusevich IN, Kurashova NA, Suturina LV, Grebenkina LA, Dolgikh MI. Features of lipid peroxidation and antioxidant protection in women with chronic endometritis and reproductive disorders. Fundamentalnye Issledovaniya, 2013, 9-5.

27. Kungurtseva EA, Leshchenko OYa, Danusevich IN, Popkova SM, Shabanova NM, Nemchenko UM, Dzhioev YuP. Vaginal microecology in women with nonspecific genital inflammatory diseases and reproductive disorders. Byulleten Vostochno-Sibirskogo Nauchnogo Tsentra Sibirskogo Otdeleniya Rossiyskoy Akademii Meditsinskikh Nauk, 2013, 3: 43-48.


Review

For citations:


Manukhin, IB, Sementsova NA, Mitrofanova YY, Livshits LY. Chronic endometritis and habitual miscarriage. Meditsinskiy sovet = Medical Council. 2018;(7):46-49. (In Russ.) https://doi.org/10.21518/2079-701X-2018-7-46-49

Views: 805


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)