The micronized progesterone in complex therapy of pregnant women with missed abortion in the anamnesis

Objective. To evaiuate the course of pregnancy against the background of use of the micronized progesterone (Prajisun) at women with missed abortion in the anamnesis. Subjects and methods. In a research 230 women with missed abortion in the anamnesis. From them 128 patients received preconception treatment by the micronized progesterone of 300 mg per a day intravaginally in a luteal phase of menstrual cycle for 3 months and 200 mg twice a day after positive pregnancy test up to 12 weeks (the I group); 102 pregnant women have begun intake of medicine of the micronized progesterone of 200 mg twice a day intravaginally from the moment after diagnostics of pregnancy up to 12 weeks of a gestation (the II group). To all patients the full range of all-clinical trials according to the Order MOH Russian Federation № 572n «About the statement of the Order of delivery of health care on the «obstetrics and gynecology (except for use of auxiliary reproductive technologies)» profile was carried out. In the course of the research the courses of the real pregnancy given relatively were fixed: existence of complications from mother and a newborn. The statistical analysis of data is made with use of Statistica 10.0 Rus. Results. The main criterion for the therapy effectiveness was prolongation of the pregnancy up to 22 weeks of a gesattion. In the I group (the patient who have pregravid preparation by micronized progesterone), the frequency of termination of pregnancy was 0,8% whereas in the II group (intake of the micronized progesterone has been begun after the pregnancy diagnostics) – 7,8% (р<0,05). As a result of the analysis of the obtained data decrease in risk of termination of pregnancy at patients with a cancelled abortion has been shown in the anamnesis at use of medicine of the micronized progesterone from a pregravidarny stage in comparison with primeneiy the micronized progesterone only with pregnancy approach (р<0,05). Conclusion. Results of a research demonstrate effectiveness and safety of micronized progesterone (Prajisun) in a complex of pregravid preparation of women with missed abortion in the anamnesis. Use of the micronized progesterone after the diagnostics of pregnancy is less effective.

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