Preview

Meditsinskiy sovet = Medical Council

Advanced search

Optimization of the method for predicting clinical outcomes of reactive arthritis in children

https://doi.org/10.21518/2079-701X-2018-11-117-121

Abstract

The comparative analysis of content of cytokine and significant local antimicrobial factors (IL-6, IL-8, IL-17, INF-γ, TNF-α, IL-10, CRP, lysozyme, lactoferrin) in the coprofiltrates and serum of patients with acute and chronic reactive arthritis (ReA) made it possible to determine the markers predicting the course and outcomes of arthritis. It is established that the method of predicting ReA involving the analysis of the parameters characterizing coprofiltrates of children is the more accurate and effective method.

 

About the Authors

O. E. Chelpachenko
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Orenburg
Russian Federation


E. I. Danilova
Orenburg State Medical University of the Ministry of Health of Russia
Russian Federation


I. A. Nikiforov
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Orenburg
Russian Federation


I. N. Chainikova
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Orenburg
Russian Federation


N. B. Perunova
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Orenburg
Russian Federation


E. V. Ivanova
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Orenburg
Russian Federation


L. P. Fedotova
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Orenburg
Russian Federation


References

1. Alekseeva EI, Baranov AA, Shuvalova MP. Rheumatic diseases in children in the Russian Federation: scale of the problem. Pediatriya. Appendix 3 Aktualnye Voprosy Detskoy Kardiologii Na VII Kongresse Pediatrov Rossii, 2003: 2-10.

2. Gill T, Asquith M, Rosenbaum JT et al. The intestinal microbiome in spondyloarthritis. Curr. Opin. Rheumatol., 2015, 27(4): 319-325.

3. Hreggvidsdottir HS, Noordenbos T, Baeten DL. Inflammatory pathways in spondyloarthritis. Molecular Immunology, 2014, 57(1): 28-37.

4. Chen K, Kolls JK. Interluekin-17A (IL17A). Gene, 2017, 614: 8-14.

5. Beringer A, Noack M, Miossec P. IL-17 in Chronic Inflammation: From Discovery to Targeting. Trends Mol Med, 2016, 22(3): 230-41. doi: 10.1016/j.molmed.2016.01.001.

6. Smith JA, Colbert RA. Review: The interleukin-23/ interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol, 2014, 66: 231-241.

7. Raychaudhuri SP, Raychaudhuri SK. Mechanistic rationales for targeting interleukin-17A in spondyloarthritis. Arthritis Research & Therapy, 2017, 19: 51. doi:10.1186/s13075-017-1249-5.

8. Rosenbaum JT, Asquith MJ. The microbiome: A revolution in treatment for rheumatic diseases? Curr. Rheumatol. Rep., 2016, 18: 62.

9. Isailovic N, Daigo K, Mantovani A, Selmi C. Interleukin-17 and innate immunity in infections and chronic inflammation. Journal of Autoimmunity, 2015, 60: 1-11.

10. Wendling D, Guillot X, Prati C. The IL-23/Th 17 pathway in spondyloarthritis: the royal road? Joint Bone Spine, 2015, 82(1): 1-4.

11. Miossec P. Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice. RMD Open, 2017, 3(1): e000284. doi:10.1136/rmdo-pen-2016-000284.

12. Yago T, Nanke Y, Kawamoto M et al. IL-23 and Th17 Disease in Inflammatory Arthritis. Andrès E, ed. Journal of Clinical Medicine, 2017, 6(9): 81. doi:10.3390/jcm6090081.

13. Nasonov EL. Reactive arthritis. Clinical guidelines. Rheumatology. Edited by Nasonova EL, Moscow: GEOTAR-Media, 2008: 86-91.

14. Gaponova ТV. Clinico-immunological associations with reactive arthritis of various etiologies: Dissertation of PhD in medicine. St. Petersburg., 2009, 116 p.

15. Isakanova AO. Immunogenetic characteristics of reactive arthritis depending on the clinical picture and etiological variants of its development. Extended abstract of PhD in medicine Dissertation. Chelyabinsk, 2000, 24 p.

16. Chaplygina LN. Clinical and diagnostic value of lactoferrin and cytokine molecules in patients with reactive arthritis. Extended abstract of PhD in medicine Dissertation, Yaroslavl, 2007, 24 p.

17. Asquith M, Elewaut D, Lin P, Rosenbaum JT. The role of the gut and microbes in the pathogenesis of spondyloarthritis. Best Pract Res Clin Rheumatol, 2014, 28(5): 687–702.

18. Ohland CL, Jobin C. Microbial activities and intestinal homeostasis: A delicate balance between health and diseases. Cell Mol. Gastroenterol. Hepatol., 2015, 1(1): 28-40.

19. Omenetti S, Pizarro TT. The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome. Front Immunol, 2015, 6: 639.


Review

For citations:


Chelpachenko OE, Danilova EI, Nikiforov IA, Chainikova IN, Perunova NB, Ivanova EV, Fedotova LP. Optimization of the method for predicting clinical outcomes of reactive arthritis in children. Meditsinskiy sovet = Medical Council. 2018;(11):117-121. (In Russ.) https://doi.org/10.21518/2079-701X-2018-11-117-121

Views: 618


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)