Therapy for erosive esophagitis induced by mixed reflux in patients with CAD
https://doi.org/10.21518/2079-701X-2018-14-73-77
Abstract
The article presents the results of using a combination of PPI (pantoprazole) and UDCA for the treatment of erosive esophagitis induced by mixed reflux in patients with coronary artery disease.
A total of 62 patients with EGDS-proven erosive esophagitis were enrolled in the study. The patients were divided into two groups: the active treatment group (ATG) which included 34 patients with erosive reflux esophagitis and control group (CG), which included 28 patients with erosive reflux esophagitis without CAD. The patients of both groups received IPP (pantoprazole) 80 mg/day and UDCA at a dosage of 15 mg/kg/day for 12 weeks. (84 days).
The study showed that complete epithelialization of esophageal mucosa defects was detected in 100% of ATG patients by Day 84 of therapy, the same was achieved in CG patients by Day 56 of the basic course of therapy.
The treatment of EE induced by mixed reflux with a combination of PPI (pantoprazole) at a dose of 80 mg/day and UDCA at a dosage of 15 mg/kg/day was efficient in patients with GERD and CAD as a basic course of therapy for not less than 84 days. An effective dose of UDCA for maintenance therapy is 5 mg/kg/day in combination with PPI at a daily dose of 40 mg for not less than 2 months.
About the Authors
O. N. Minushkin
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
A. G. Shuleshova
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
K. A. Bondarev
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
D. V. Danilov
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Pakhomova IG, Zinovieva EN. Gastroesophageal reflux disease in a polymorbid patient: features of therapy. RMJ, 2017, 10: 760-764.
2. Alekseeva OP, Dolbin IV, Pikulev DV. Combined course of coronary artery disease and gastroesophageal reflux disease. Nizhegorodskiy Meditsinskiy Zhurnal, 2006, 7: 7-13.
3. Shilov AM, Melnik MV, Osiya AO. Coronary artery disease and gastroesophageal reflux disease in primary care practice. Lechashchy Vrach, 2010, 7: 86-88.
4. Liu Y, He S, Chen Y, Xu J, Tang C, Tang Y, Luo G. Acid reflux in patients with coronary artery disease and refractory chest pain. Intern Med, 2013, 52(11): 1165-71.
5. Pulkowski G, Majer M, Budzyński J, Swiatkowski M. Gastroesophageal reflux disease and coronary heart disease-coexistence or interrelationship? Pol Merkur Lekarski, 2006, 2, 115: 104-8.
6. Belenkov YuN, Privalova EV, Yusupova AO, Kozhevnikova MV. Coronary artery disease and reflux-esophagitis: complexity of differential diagnosis and treatment of patients. RGGK, 2011, 3, XXI: 4-12.
7. Lazebnik LB, Masharova AA, Bordin DS, et al. Results of the Multicentre Gastroesophageal Reflux Disease Epidemiology in Russia (MEGRE) study. Terapevt. Arkh. 2011, 1: 45-50.
8. Yurenev GL, Kazyulin AN, Yureneva-Tkhorzhevskaya ТV. The effect of acid-suppressive therapy on the clinical course of coronary artery disease with refractory pain in the chest. Terapiya, 2015, 2 (2): 1-8.
9. Bortolotti M, Labriola E, Bacchelli S, Degli Espositi D, Sarti P, Brunelli F et al. «Oesophageal angina» in patientswith angina pectoris: a possible side effect of chronic therapy with nitroderivates and Ca-antagonists. Ital J Gastroenterol, 1992, 24(7): 405-8.
10. Minushkin ON, Maslovsky LV, Shuleshova AG, Nazarov NS. Some approaches to treatment of patients with reflux-esophagitis who underwent gastrectomy. Kremlin medicine. Klinicheskiy Vestnik, 2014, 4: 18-24.
11. Dolzhenko MN, Bazilevich AYa. New aspects of UDCA administration: the cardiologist view. Medichna Gazeta Zdorovya Ukraїni 21 Storіchchya, 2017, 19: 416.
Review
For citations:
Minushkin ON, Shuleshova AG, Bondarev KA, Danilov DV. Therapy for erosive esophagitis induced by mixed reflux in patients with CAD. Meditsinskiy sovet = Medical Council. 2018;(14):73-77. (In Russ.) https://doi.org/10.21518/2079-701X-2018-14-73-77
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