ARVI antiviral therapy in children in modern clinical practice
https://doi.org/10.21518/2079-701X-2019-2-183-187
Abstract
In the context of the wide range of products recommended for antiviral therapy, there is still a need for continuous evaluation of their effectiveness and safety in pediatrics. The work describes the experience of non-interventional study of the domestic drug umifenovir in the modern clinical practice. The authors studied 216 case histories of children hospitalized with acute respiratory viral infections at early stages of the disease. Against the background of the drug administration a significant reduction in the duration of all symptoms of the infectious process and the need to prescribe antibiotic therapy to patients, a reduction in the chances of complicated flu and acute respiratory viral infections, as well as a favorable safety spectrum and a high level of compliance during treatment.
About the Authors
E. A. Dondurey
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation;
St. Petersburg State Budgetary Healthcare Institution «Nil Fedorovich Filatov Children’s City Clinical Hospital No. 5»
Russian Federation
Russian Federation
Dondurey Elena Alexandrovna – PhD in Medical sciences, Senior Researcher at the Department of Children’s Influenza at the Federal State Institution «Scientific Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation, Head of the Infectious Diseases Department of the Moscow City Children’s Clinical Hospital No.13 named after N.F. Filatov of the Moscow City Health Department
197376 Saint-Petersburg, Professor Popov Street, 15/17, 134 Bukharestskaya Str., St. Petersburg, 192289
E. V. Obraztsova
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Obraztsova Elena Viktorovna – PhD in Medical sciences, Senior Researcher at the Department of Children’s Influenza
197376 Saint-Petersburg, Professor Popov Street, 15/17
Yu. S. Semiletko
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation;
St. Petersburg State Budgetary Healthcare Institution «Nil Fedorovich Filatov Children’s City Clinical Hospital No. 5»
Russian Federation
Russian Federation
Semiletko Yulia Sergeevna – Infectious Disease Physician of the Federal State Budgetary Institution, City Children’s Clinical Hospital No.13 named after N.F. Filatov of the Moscow City Healthcare Department
197376 Saint-Petersburg, Professor Popov Street, 15/17, 134 Bukharestskaya Str., St. Petersburg, 192289
N. V. Ovchinnikova
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation;
St. Petersburg State Budgetary Healthcare Institution «Nil Fedorovich Filatov Children’s City Clinical Hospital No. 5»
Russian Federation
Russian Federation
Ovchinnikova Nadezhda Viktorovna – Infectious Disease Physician of the Federal State Budgetary Institution, City Children’s Clinical Hospital No.13 named after N.F. Filatov of the Moscow City Healthcare Department
197376 Saint-Petersburg, Professor Popov Street, 15/17, 134 Bukharestskaya Str., St. Petersburg, 192289
E. G. Golovacheva
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Golovacheva Ekaterina Georgievna – Grand PhD in Medical sciences, Senior Researcher at the Department of Children’s Studies
197376 Saint-Petersburg, Professor Popov Street, 15/17
L. V. Osidak
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Osidak Lyudmila Viktorovna – Grand PhD in Medical sciences, Professor, Leading Researcher at the Department of Children’s Studies
197376 Saint-Petersburg, Professor Popov Street, 15/17
O. I. Afanasyeva
Federal State Budgetary Institution «Research Institute of Influenza named after A.A. Smorodintsev» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Afanasyeva Olga Ivanovna – Grand PhD in Medical sciences, Head of the Department of Children’s Influenza
197376 Saint-Petersburg, Professor Popov Street, 15/17
References
1. Belousov D.Yu. Noninterventional clinical trials. Qualitative clinical practice [Kachestvennaya klinicheskaya praktika]. 2017;1:24-33. (In Russ).
2. Volskaya E.A. Fundamentals of good practice in non-interventional drug research. Qualitative clinical practice [Kachestvennaya klinicheskaya praktika]. 2011;1:19-24. (In Russ).
3. Belousov D.Yu., Cheberda A.E. Pharmacoepidemiological research: methodology and regulation. Qualitative clinical practice [Kachestvennaya klinicheskaya praktika]. 2017;1:34-41. (In Russ).
4. Leneva I.A., Russell R.J., Boriskin Y.S., Hay A.J. Characteristics of Arbidol-Resistant Mutants of Influenza Virus: Implications for the Mechanism of Anti-Influenza Action of Arbidol. Antiviral Research. 2009;81:132-140.
5. Rebrova O.Yu. Statistical analysis of medical data. Application of STATISTICA package. M.: MediaSphere, 2002. 312 с. (In Russ).
6. Leneva I.A., Burtseva E.I., Yatsyshina S.B., Fedyakina I.T., Kirillova E.S., Selkova E.P., Osipova E., Maleev V.V. Virus susceptibility and clinical effectiveness of anti-influenza drugs during the 2010-2011 influenza season in Russia. International journal of infectious diseases. 2016;43:77-84.
7. Pécheur E.I., Borisevich V., Halfmann P., Morrey J.D., Smee D.F., Prichard M., Mire C.E., Kawaoka Y., Geisbert T.W., Polyak S.J. The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses. Journal of virology. 2016 Jan 6;90(6):3086-92.
8. Blaising J., Polyak S.J., Pécheur E.I. Arbidol as a broad-spectrum antiviral: an update. Antiviral research. 2014 Jul;107:84-94.
9. Liu Q., Xiong H.R., Lu L., Liu Y.Y., Luo F., Hou W., Yang Z.Q. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta pharmacologica sinica. 2013 Aug;34(8):1075-83.
10. Brancato V., Peduto A., Wharton S., Martin S., More V., Di Mola A., Massa A., Perfetto B., Donnarumma G., Schiraldi C., Tufano M.A., de Rosa M., Filosa R., Hay A. Design of inhibitors of influenza virus membrane fusion: synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series. Antiviral research. 2013 Aug;99(2):125-35.
11. Kadam R.U., Wilson I.A. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol. Proc Natl Acad Sci US. 2017 Jan 10;114(2):206-214.
Review
For citations:
Dondurey EA, Obraztsova EV, Semiletko YS, Ovchinnikova NV, Golovacheva EG, Osidak LV, Afanasyeva OI. ARVI antiviral therapy in children in modern clinical practice. Meditsinskiy sovet = Medical Council. 2019;(2):183-187. (In Russ.) https://doi.org/10.21518/2079-701X-2019-2-183-187
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