Онкофертильность у женщин, излеченных в детстве от лимфомы ходжкина

Современным стандартом выбора лечебного режима лимфомы Ходжкина в детском возрасте является концепция рискадаптированной терапии. Как правило, пациенты распределяются в зависимости от количества факторов в группы низкого,  промежуточного и высокого риска с тем или иным объемом лечебной программы. Благодаря рациональному использованию  химио- и лучевой терапии возможно снижение риска возникновения гонадной токсичности. Потеря ооцитов у пациенток, получавших терапию лимфомы Ходжкина в детстве, как правило, связана с воздействием системной химиотерапии и облучением  таза. В качестве скринингового маркера для оценки гонадотоксичного действия химиолучевой терапии, причем и у девочек, и  у мальчиков, предлагается использовать сочетание ингибина В и ФСГ. 

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