Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight

Aim: to study the association of the levels of leptin and its soluble receptor in blood serum with nonalcoholic fatty liver disease (NAFLD) in obese or overweight patients. Material and methods: the open study included 105 patients with obesity or excess body weight. Patients were examined for NAFLD and divided into two groups: the treatment group included patients with NAFLD (n = 77) and the control group included patients without NAFLD (n = 28). Results: complaints of pain in the right upper quadrant, hypertension and diabetes type 2, as well as waist circumference, body mass index, glucose and triglyceride levels were reported significantly more frequently in the group of patients with NAFLD. Leptin was positively and the level of its receptors was negatively correlated with the degree of weight gain. Between these parameters in the group of patients with obesity and excess body weight, an overall moderate negative correlation was reported (rs = (-0.370), p <0.004). There was a tendency towards higher levels of leptin and lower levels of leptin receptors in the group of patients with NAFLD. In the treatment group, these parameters also had a moderate negative correlation (rs = (-0.384), p <0.007). Conclusion: the phenomenon of leptin resistance which occurs in individuals with obesity and excess body weight is associated with the development of NAFLD in this category of patients.

ожирение, избыток массы тела, неалкогольная жировая болезнь печени, лептин, лептинорезистентность, obesity, excess body weight, non-alcoholic fatty liver disease, leptin, leptin resistance

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