Preview

Meditsinskiy sovet = Medical Council

Advanced search

Treatment of the vaginal disbiotic disorders in pregnant women before delivery

https://doi.org/10.21518/2079-701X-2019-13-64-69

Abstract

The urgency of the problem of vaginal infection is determined by its highest prevalence in the structure of obstetric-gynecological morbidity. Currently, the share of diseases of the lower genital tract associated with quantitative unbalance conditionally pathogenic microorganisms of bacterial and fungal origin vagina, which occur in 40-65% of pregnant women. Carried out a sufficient number of studies showing the role of vaginal microbiocenosis dysbiotic violations in the development of pathology of pregnancy, childbirth and postpartum infectious complications. It is known, that for vaginal infections and dysbiosis significantly more often increases the risk of chronic placental insufficiency, premature birth, low birth weight and postpartum endometritis, wound infection. In connection with the above, it is important to timely diagnose microflora disorders using clinical and laboratory research methods, followed by adequate etiotropic therapy. Timely and effective treatment of vaginal dysbiosis in pregnant women before delivery reduces the risk of postpartum infectious complications.

About the Authors

V. L. Tyutyunnik
National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation

Victor L. Tyutyunnik, Dr. of Sci. (Med.), Professor, Head of the 1st Obstetric Physiological Department

4, Oparina str., Moscow, 117997



A. A. Balushkina
National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation

Anna A. Balushkina, Cand. of Sci. (Med.), Researcher

4, Oparina str., Moscow, 117997



A. A. Mikhailova
National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation

Olga I. Mikhailova, Cand. of Sci. (Med.), Obstetrics and Gynecology Doctor, Researcher Department of Molecular Diagnostic Methods and Personalized Medicine

4, Oparina str., Moscow, 117997



N. E. Kan
National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation

Natal’ya E. Kan, Dr. of Sci. (Med.), Professor of Chair for Obstetrics and Gynecology

4, Oparina str., Moscow, 117997



References

1. Dobrokhotova Yu.E., Ilyina I.Yu. Treatment of vaginal infectious diseases. RMZH. Mat’ i ditya = RMJ. Russian Journal of Woman and Child Health. 2017;(15):1108-1110. (In Russ.) Available at: https://www.rmj.ru/articles/ginekologiya/Lechenie_infekcionnyh_zabolevaniy_vlagalischa/#ixzz5z6pynz1Q.

2. Rishchuk S.V. Vaginal dysbiosis: a new view of the problem. Vopr. ginekol. akus. perinatol. Voprosy ginekologii, akusherstva i perinatologii = Gynecology, Obstetrics and Perinatology. 2016;15(3):54–63. (In Russ.) Available at: http://www.rishchuk.ru/pdf/179rischukdisbioz-vaginyivagiferon2016.pdf.

3. Brown R.G., Al-Memar M., Marchesi J.R., Lee Y.S., Smith A., Chan D., Lewis H., Kindinger L., Terzidou V., Bourne T., Bennett P.R., MacIntyre D.A. Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes. Transl Res. 2019;207:3043. doi: 10.1016/j.trsl.2018.12.005.

4. Karapetyan T.E., Muravieva V.V., Ankirskaya A.S. et al. Opportunities for treating opportunistic vaginal infections during pregnancy. Ginekologiya = Gynecology. 2017;19(6):11–15. (In Russ.) doi: 10.26442/2079-5696_19.6.11-15

5. Siniakova AA. Current views on vaginal microbiota and its impact on pregnancy outcomes. Zhurnal akusherstva i zhenskikh bolezney = Journal of Obstetrics and Women’s Diseases. 2017;66(6):89100. (In Russ.) doi: 10.17816/JOWD66689-100.

6. Tkachenko L.V., Uglova N.D., Sviridova N.I., Skladanovskaya T.V. Modern approach to the treatment of vulvovaginal infections. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie = Obstetrics and Gynecology: News, Opinions, Training. 2018;(4):52-58. (In Russ.) doi: 10.24411/2303-9698-2018-14006.

7. Voroshilina E.S., Zornikov D.L., Plotko E.E. Normal vaginal microbiota: patient’s subjective evaluation, physical examination and laboratory tests. Vestnik Rossiyskogo gosudarstvennogo meditsinskogo universiteta = Bulletin of RSMU. 2017;(2):42-46. (In Russ.) doi: 10.24075/brsmu.2017-02-06.

8. Karapetyan T.E., Ankirskaya A.S., Muravyova V.V. Bacterial vaginosis in the first trimester of pregnancy. Meditsinskiy sovet = Medical Council. 2015;(XX):68-71. (In Russ.) doi: 10.21518/2079-701X-2015-XX-68-71.

9. Yu F., Tang Y.T., Hu Z.Q., Lin X.N. Analysis of the Vaginal Microecological Status and Genital Tract Infection Characteristics of 751 Pregnant Women. Med Sci Monit. 2018;24:5338–5345. doi: 10.12659/MSM.909051.

10. Podgornaya A.V., Makhmutkhodzhaev A.S. Vaginal biocenosis in pregnant women. Akusherstvo, Ginekologiya i Reproduktsiya = Obstetrics, Gynecology and Reproduction. 2017;11(3):43-49. (In Russ.) doi: 10.17749/2313-7347.2017.11.3.043-049.

11. Khayutin L.V., Plotko E.E., Voroshilina E.S. Vaginal anaerobic dysbiosis during pregnancy: ways of treatment and the characteristics of the pregnancy course. Ural’skiy Meditsinskiy Zhurnal = Ural Medical Journal. 2016;(2):55-60. (In Russ.) Available at: https://elibrary.ru/item.asp?id=25631749.

12. Van de Wijgert J.H.H.M., Jespers V. The global health impact of vaginal dysbiosis. Res Microbiol. 2017;168(9-10):859-864. doi: 10.1016/j.resmic.2017.02.003.

13. Murashko M.P., Murashko A.A. Bacterial vaginosis: a modern view of the problem. Meditsinskiy sovet = Medical Council. 2015;(11):80-83. (In Russ.) doi: 10.21518/2079-701X-2015-11-80-83.

14. Reiter S., Kellogg Spadt S. Bacterial vaginosis: a primer for clinicians. Postgrad Med. 2019;131(1):818. doi: 10.1080/00325481.2019.1546534.

15. Dobrokhotova Yu.E., Bondarenko K.R., Gushchin A.E., Rumyantseva T.A., Dolgova T.V., Kuznetsov P.A., Dzhokhadze L.S. The results of the examination of cervical-vaginal microbiota in pregnant women with threatened preterm birth using a real-time polymerase chain reaction. Akusherstvo i Ginekologiya = Obstetrics and Gynecology. 2018;(11):50-59. (in Russ.) doi: 10.18565/aig.2018.11.50-59.

16. Han C., Li H., Han L., Wang C., Yan Y., Qi W., Fan A., Wang Y., Xue F. Aerobic vaginitis in late pregnancy and outcomes of pregnancy. Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):233239. doi: 10.1007/s10096-018-3416-2.

17. Stout M.J., Zhou Y., Wylie K.M., Tarr P.I., Macones G.A., Tuuli M.G. Early pregnancy vaginal microbiome trends and preterm birth. Am Am J Obstet Gynecol. 2017;217(3):356.e1-356.e18. doi: 10.1016/j.ajog.2017.05.030

18. Solovyeva A.V., Gerasimova O.P., Ermolenko K.S., Gevorgyan D.A. The status of biocenosis in pregnant women with a history of recurrent miscarriage. Akusherstvo i Ginekologiya = Obstetrics and Gynecology. 2018;(10):106-111. (In Russ.) doi: 10.18565/aig.2018.10.106-111.

19. Freitas A.C., Bocking A., Hill J.E., Money D.M.; VOGUE Research Group. Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth. Microbiome. 2018;6(1):117. doi: 10.1186/s40168-018-0502-8.

20. Dobrokhotova Yu.E., Semioshina O.E. Antiseptics… Renaissance in the therapy of vulvovaginal infections or new perspectives and expectations ? RMZH. Mat’ i ditya = RMJ. Russian Journal of Woman and Child Health. 2018;2(I):3942. (In Russ.) Available at: https://www.rmj.ru/articles/ginekologiya/Antiseptiki_Renessans_vterapii_vulyvovaginalynyh_infekciy_ili_novye_perspektivy_ioghidaniya/#ixzz5z7CHRdEo.

21. Caissutti C., Saccone G., Zullo F., Quist-Nelson J., Felder L., Ciardulli A., Berghella V. Vaginal Cleansing Before Cesarean Delivery: A Systematic Review and Meta-analysis. Obstet Gynecol. 2017;130(3):527-538. doi: 10.1097/AOG.0000000000002167.

22. Haas D.M., Morgan S., Contreras K., Enders S. Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections. Cochrane Database Syst Rev. 2018;(7): CD007892. doi: 10.1002/14651858.CD007892.


Review

For citations:


Tyutyunnik VL, Balushkina AA, Mikhailova AA, Kan NE. Treatment of the vaginal disbiotic disorders in pregnant women before delivery. Meditsinskiy sovet = Medical Council. 2019;(13):64-69. (In Russ.) https://doi.org/10.21518/2079-701X-2019-13-64-69

Views: 2830


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)