Clinical profile of patients with severe asthma
https://doi.org/10.21518/2079-701X-2015-16-46-49
Abstract
The article presents the results of the authors' trial involving 119 patients (aged 22 to 82 years) with severe bronchial asthma (BA) diagnosed according to the ERS/ATS guidelines (2014). Allergic asthma was diagnosed in 77% of patients. The study focused on house dust mites as the main allergens in the sensitization spectrum. A significant proportion of patients (82%) had uncontrolled course of the disease, and 76% suffered from airflow limitation that is not fully reversible. Markers of eosinophilic airway inflammation (nitric oxide in exhaled air and level of blood eosinophils above 150 cells per 1 µL) were found in 63% of patients. Good adherence to treatment (administration of more than 75% of the prescribed doses of drugs) was observed in 61% of patients. Among patients with severe asthma 27% were active smokers. Smokers demonstrated a decreased pulmonary function and a lower level of nitric oxide in exhaled air. Smokers were also less adherent to treatment with inhaled corticosteroids. Severe BA was combined with COPD in 37% of cases.
Keywords
тяжелая бронхиальная астма,
фенотипы,
лечение,
курение,
severe asthma,
phenotypes,
treatment,
smoking
About the Authors
G. R. Sergeeva
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
A. V. Emelyanov
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
O. V. Korovina
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
A. A. Znakhurenko
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
E. V. Leshenkova
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
L. V. Kozyreva
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
N. . Asatiani
Pulmonologym North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Sergeeva GR, Emelyanov AV, Korovina OV, Znakhurenko AA, Leshenkova EV, Kozyreva LV, Asatiani N. Clinical profile of patients with severe asthma. Meditsinskiy sovet = Medical Council. 2015;(16):46-49. (In Russ.) https://doi.org/10.21518/2079-701X-2015-16-46-49
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