Duodenogastric refluх: a look at the problem in terms of carcinogenesis
https://doi.org/10.21518/2079-701X-2019-14-108-111
Abstract
The role of duodenogastric reflux (DGR) in malignant degeneration of the gastric mucosa. It was demonstrated by immunohistochemistry using monoclonal antibodies to p53, PCNA, CD10, MUC2, MUC5AC, MUC6, CD31 and the polymerase chain reaction to detect CDX1, CDX2, FXR genes. The main carcinogenic components of bile are lysolecithin and conjugated bile acids. Biliary reflux increases the risk of malignant tumors in combination with Helicobacter pylori. DGR is one of the etiological factors for gastric cancer, so it determines the necessity for detailed diagnosis in clinical practice.
About the Authors
Z. M. Galeeva
Kazan State Medical Academy – a branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Zarina M. Galeeva, Cand. of Sci. (Med.), Associate Professor, Chair for Therapy, Geriatrics and Family Medicine, Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuing Professional Education» of the Ministry of Health of the Russian Federation
36, Butlerova St., Kazan, 420012
R. G. Toukhbatullina
Institute of Pharmacy, Kazan State Medical University
Russian Federation
Russian Federation
Ruzaliya G. Toukhbatullina, Dr. of Sci. (Ph), Professor, Head of Biotechnology Laboratory, Institute of Pharmacy, Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuing Professional Education» of the Ministry of Health of the Russian Federation
49, Butlerova St., Kazan, 420012
A. I. Gaisina
Kazan State Medical University
Russian Federation
Russian Federation
Aida I. Gaisina, a 5th year student, Medical and Biological Department, Federal State Budgetary Educational Institution of Higher Education
49, Butlerova St., Kazan, 420012
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Review
For citations:
Galeeva ZM, Toukhbatullina RG, Gaisina AI. Duodenogastric refluх: a look at the problem in terms of carcinogenesis. Meditsinskiy sovet = Medical Council. 2019;(14):108-111. (In Russ.) https://doi.org/10.21518/2079-701X-2019-14-108-111
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