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Ожирение как фактор риска нарушения обмена железа

https://doi.org/10.21518/2079-701X-2015-17-144-148

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Аннотация

Приводятся данные о патогенетической связи между железодефицитом и наличием системного воспаления, ассоциированного с ожирением. В условиях хронического воспаления при ожирении запускается механизм секвестрации железа, преимущественно клетками макрофагальной системы и жировой ткани, снижается эффективность усвоения железа из пищи, поступление его в эритроидные клетки и синтез гема. Избыточно накопленное в клетках жировой ткани железо индуцирует оксида-тивный и эндоплазматический стресс, выработку провоспалительных цитокинов, т. е. воздействует на основные звенья патогенеза ожирения и усугубляет его. Имеются клинические данные об улучшении показателей обмена железа и снижении уровня сывороточного гепсидина у больных при снижении веса после бариатрических операций. Данные о частоте и патогенетическом варианте анемии (железодефицитная или анемия хронических заболеваний) после бариатрических операций неоднозначны.

Об авторах

Л. И. Дворецкий
Первый Московский государственный медицинский университет им. И.М. Сеченова
Россия


О. В. Ивлева
Первый Московский государственный медицинский университет им. И.М. Сеченова
Россия


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