Treatment options of the nasal cavity and paranasal sinuses diseases
https://doi.org/10.21518/2079-701X-2019-17-107-111
Abstract
Currently, the pathology of the nasal cavity and paranasal sinuses is an urgent public health problem. Rhinosinusitis is one of the leading causes of patients seeking medical attention. In addition to traditional anti-inflammatory, antibacterial, decongestant and antihistamine therapy, agents with mucolytic properties are widely used. The basis of rhinosinusitis is a process of violation of mucociliary clearance. Sinonasal secretions in rhinosinusitis are more viscous,elastic, and adhesive than normal nasal mucus. A change in the composition of the nasal secretion leads to stagnation of the contents in the sinuses, promotes bacterial colonization. The appointment of mucolytics regulates secretion and normalizes the viscosity of the secretion. The article provides an example of the clinical use of Sinupret®.
About the Authors
S. A. KarpishchenkoRussian Federation
Sergey A. Karpishchenko, Dr. of Sci. (Med.), Professor, Acting Director, Federal State Budget Institution «Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech» of the Ministry of Health of the Russian Federation; Head of Chair for Otorhinolaryngology, Federal State Budgetary Educational Institution of Higher Education «Pavlov First Saint Petersburg State Medical University» of the Ministry of Health of the Russian Federation
9 Bronnitskaya St., Saint Petersburg, 190013,
6–8 Lva Tolstogo St., Saint Petersburg, 197022
S. V. Baranskaya
Russian Federation
Svetlana V. Baranskaya, Otorhynolaryngologist, Chair for Otorhinolaryngology, Junior Researcher, Otorhinolaryngology Department, Pavlov First Saint Petersburg State Medical University, Teaching Assistant of Chair for General Medical Practice (Family Medicine)
6–8 Lva Tolstogo St., Saint Petersburg, 197022
References
1. Hardcastle T., Jain R., Radcliff F., WaldvogelThurlow S., Zoing M., Biswas K., Douglas R. The in vitro mucolytic effect of xylitol and dornase alfa on chronic rhinosinusitis mucus. International Forum of Allergy & Rhinology. 2017;7(9):889–896. doi: 10.1002/alr.21970.
2. Scholes M.A., Ramakrishnan V.R. (ed.). Otorhinolaryngology. Theory and practice. Translation from English by Karpishchenko S.A. (ed.). Moscow: GEOTAR-Media; 2018. 704 p.
3. Budkovaya M.A., Artemyeva E.S. The specific features of nasal breathing disorders in patients with nasal obstruction. Rossiyskaya otorinolaringologiya = Russian Otorhinolaryngology . (In Russ.). 2019;18(1):16-23. Available at: https://elibrary.ru/item.asp?id=37051901.
4. Subbotina M.V., Kunitsyna M.N., Buksha I.A., Galchenko M.T., Platonenko O.I. The use of sinupret in the combined treatment of acute otitis media in children. Vestnik otorinolaringologii = Bulletin of Otorhinolaryngology. 2009;(2):43-45. Available at: https://elibrary.ru/item.asp?id=13332583.
5. Magit A. Pediatric Rhinosinusitis. Otolaryngologic Clinics of North America. 2014;47(5):733–746. doi: 10.1016/j.otc.2014.06.003.
6. Brook I. The role of antibiotics in pediatric chronic rhinosinusitis. Laryngoscope Investigative Otolaryngology. 2017;2(3):104–108. doi: 10.1002/lio2.67.
7. Karpishchenko S.A., Lavrenova G.V., Shakhnazarov A.E., Muratova E.I. Acute and chronic rhinosinusitis: additional opportunities for conservative therapy. Zhurnal otorinolaringologii i respiratornoy patologii = Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2018;24(4):19-20. (In Russ.) Available at: http://foliaopr.spb.ru/wp-content/uploads/2018/04/Folia_24_4_2018.pdf.
8. Fokkens W. J. Lund V.J., Mullol J., Bachert C., Alobid I., Baroody F., et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50(1):1-12. doi: 10.4193/Rhino50E2.
9. Passali D., Loglisci M., Passali G.C., Cassano P., Rodriguez H.A., Bellussi L.M.A Prospective Open-Label Study to Assess the Efficacy and Safety of a Herbal Medicinal Product (Sinupret) in Patients with Acute Rhinosinusitis. ORL J Otorhinolaryngol Relat Spec. 2015;77(1):27–32. doi: 10.1159/000370123.
Review
For citations:
Karpishchenko SA, Baranskaya SV. Treatment options of the nasal cavity and paranasal sinuses diseases. Meditsinskiy sovet = Medical Council. 2019;(17):107-111. (In Russ.) https://doi.org/10.21518/2079-701X-2019-17-107-111