Role of metabolic glycemic control in programming perinatal risk in gestational diabetes

Purpose. Evaluate the effect of metabolic control of gestational diabetes mellitus (GDM) on the perinatal period course and anthropometric parameters of newborns.

Materials and methods. 300 newborns were divided into 4 groups depending on the metabolic control of the mother. Group 1: fasting glycemia <5.1 mmol/L, 1 hour after meals <7.0 mmol/L (n = 50); Group 2: <5.3 mmol/L and <7.8 mmol/L (n = 90); Group 3: > 5.3 mmol/L and> 7.8 mmol/L (n = 46), respectively; Group 4: control (n = 114). The analysis of the perinatal period course was carried out, the anthropometric parameters were estimated according to the tables INTERGROWTH-21st.

Results. Differences in the frequency of obstetric injuries, which risk is associated with «above average» body weight of the newborn (p = 0.04), were found between the GDM group and the control group (38.7 and 12.3%, respectively, p = 0.0000005). The risk of having a baby with «above average» body weight (Group 1/Group 4, OR = 1.9, p = 0.1; Gr. 2/Gr. 4, OR = 2.6, and Gr. 3/Gr. 4, OR = 3.7, p <0.05), the ratio of weight/length (Gr. 1/Gr. 4, OR = 0.9, p = 0.9; Gr. 2/Gr. 4, OR = 3.6, and Gr. 3/Gr. 4, OR = 4.9, p <0.05) and head circumference (G.1/Gr. 4, OR = 1.1, p = 0.6; Gr. 2/Gr. 4, OR = 2.5, and Gr. 3/Gr. 4, OR = 2.9, p <0.05) was higher in Groups 2 and 3 than in Group 4. In the early neonatal period with GDM, hypoglycemia was more common than in the control Group 4. The lowest risk was in Group 1 (Gr. 1/Gr. 4, OR = 4.8; Gr. 2/Gr. 4, OR = 6.7; Gr. 3/Gr. 4, OR = 7.9, р < 0,05).

Conclusions. Group 1 showed the lowest frequency and risk of adverse effects, which meets the control criteria of the Russian consensus.

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