The integrated assessment of elemental status in women of reproductive age with hypothyroidism from the Aral Sea zone of the Republic of Kazakhstan
https://doi.org/10.21518/2079-701X-2019-21-260-266
Abstract
The article dedicates to the study of microelements in the blood serum of women of reproductive age, with newly diagnosed hypothyroidism (subclinical and manifest), living in disadvantaged areas of the Aral Sea region. This article presents the study of 1154 women. Every fourth woman (25%) has an essential deficiency of such microelements like iodine, selenium, iron, zinc independently of thyroid function. Our study discovered negative associations of TSH concentration with essential microelements like manganese, copper, selenium, and positiveassociation with iodine. We also obtain positive relationships between AT-TPO and zinc and iodine. The relationship of zinc with AT – TPO level and thyroid status, especially in the regions with sufficient ioduria among residents,require further researchto study it’spossible effecton thyroid dysfunctions. We established positive associations of free T4 with essential microelements like manganese, iron, and negative association with iodine. Estimation of thyroid status and toxic microelementsrevealed positive association of free T4 with cadmium, nickel, and lead, and negativewith mercury.
About the Authors
A. A. Serikbayeva
Karaganda Medical University; Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Aigul A. Serikbayeva, assistant of professor of the Departmentof Internal Diseases No. 2
40, Gogol St., Karaganda, 100000, Kazakhstan
175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia
A. A. Turmukhambetova
Karaganda Medical University
Russian Federation
Russian Federation
Anar A. Turmukhambetova, Dr. of Sci. (Med.), Professor, Vice-Rector for Strategic development and Science
40, Gogol St., Karaganda, 100000, Kazakhstan
R. S. Dosmagambetova
Karaganda Medical University
Russian Federation
Russian Federation
Raushan S. Dosmagambetova, Dr. of Sci. (Med.), Professor, Chairman of the Board – Rector
40, Gogol St., Karaganda, 100000, Kazakhstan
L. V. Shcherbakova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Lilia V. Shcherbakova, Senior Researcher, Laboratory of Clinical-Population and Preventive Studies of Therapeutic and Endocrine Diseases
175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia
O. D. Rymar
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Oksana D. Rymar, Doctor of Science (Med.), Head of the Laboratory of Clinical-Population and Preventive Studies of Therapeutic and Endocrine Diseases
175/1, Boris Bogatkov St., Novosibirsk, 630089, Russia
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For citations:
Serikbayeva AA, Turmukhambetova AA, Dosmagambetova RS, Shcherbakova LV, Rymar OD. The integrated assessment of elemental status in women of reproductive age with hypothyroidism from the Aral Sea zone of the Republic of Kazakhstan. Meditsinskiy sovet = Medical Council. 2019;(21):260-266. (In Russ.) https://doi.org/10.21518/2079-701X-2019-21-260-266
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