Experience of application of specialized food product of dietary therapeutic and dietary preventive nutrition in case of inflammatory diseases of gastrointestinal tract
https://doi.org/10.21518/2079-701X-2020-4-107-113
Abstract
Introduction. In almost all diseases of the gastrointestinal tract, the inflammatory process plays an important pathogenetic role and affects the course of the disease and the determination of treatment tactics. The most physiological way to prevent and treat inflammatory diseases of the gastrointestinal tract, of course, is dietary nutrition.
Purpose: To study the anti- inflammatory effect of a specialized product specialized therapeutic and dietary prophylaxis nutrition «Vegetable soup with oatmeal herbs» based on a study of clinical and laboratory parameters and dynamics of inflammatory markers.
Materials and methods. An open single-center prospective observational study was conducted in parallel groups. The main group and the comparison group were 14 and 10 patients with gastrointestinal diseases, respectively. Only patients of the main group received a specialized product «Vegetable Soup with herbs and oatmeal». All participants were assessed the dynamics of clinical blood analysis indicators (hemoglobin, white blood cells, red blood cells, leukocyte formula indicators) and the dynamics of proteinogram indicators (total protein and protein fractions-albumins and globulins) and C-reactive protein (CRP).
Results. The anti-inflammatory effect after administration of the specialized product occurs in 14 days and is expressed in a reliable reduction of leukocytosis, blood sedimentation rate (BSR), CRP. After 2 months after the start of the product intake, the BSR values decreased significantly by 35%, the CRP by 51% from the baseline and the leukocyte content decreased by 14.5%. Against the background of a dietotherapy in 14 days levels α1-глобулина, α2-глобулина and γ-globulin began to decrease, and in 2 months level a1-globulins decreased by 40% of initial level to the reference values. The level of α2-globulins and γ-globulin also decreased significantly, while the albumin concentration in the blood increased significantly. In the comparison group, changes in these parameters did not reach a reliable degree of significance.
Conclusions: the specialized product «Vegetable Soup with herbs and oatmeal» has an anti-inflammatory effect, characterized by a decrease in anti-inflammatory laboratory parameters, which manifests itself after 14 days of administration, can be recommended for inclusion in the diets of patients with gastrointestinal diseases during exacerbation and during remissions as well.
About the Authors
T. L. PilatRussian Federation
Tatiana L. Pilat - Dr. of Sci. (Med.), leading researcher, Federal State Budgetary Scientific Institution “Izmerov Research Institute of Occupational Health”.
31, Prospect Budennogo, Moscow, 105275.
L. P. Kuzmina
Russian Federation
Lyudmila P. Kuzmina - Dr. of Sci. (Bio.), professor, deputy director for science, Federal State Budgetary Scientific Institution “Izmerov Research Institute of Occupational Health”; Professor of the Department of Occupational Medicine, Aviation, Space and Diving Medicine, Federal State Autonomous Educational Institution of Higher Education “Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation (Sechenov University);.
31, Prospect Budennogo, Moscow, 105275; 8/2, Trubetskaya St., Moscow, 119991.
E. L. Lashina
Russian Federation
Elena L. Lashina - Cand. of Sci. (Med.), general practitioner, head of the Department of Clinical Research, Federal State Budgetary Scientific Institution “Izmerov Research Institute of Occupational Health”.
31, Prospect Budennogo, Moscow, 105275.
M. M. Kolyaskina
Russian Federation
Mariya M. Kolyaskina - Cand. of Sci. (Med.), senior researcher of the Laboratory for Medicobiological Research, Federal State Budgetary Scientific Institution “Izmerov Research Institute of Occupational Health”; Lecturer of the Department of Occupational Medicine, Aviation, Space and Diving Medicine, Federal State Autonomous Educational Institution of Higher Education “Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation (Sechenov University).
31, Prospect Budennogo, Moscow, 105275; 8/2, Trubetskaya St., Moscow, 119991.
L. M. Bezrukavnikova
Russian Federation
Lyudmila M. Bezrukavnikova - Cand. of Sci. (Bio.), leading researcher of the Laboratory for Medicobiological Research, Federal State Budgetary Scientific Institution “Izmerov Research Institute of Occupational Health”.
31, Prospect Budennogo, Moscow, 105275.
V. V. Bessonov
Russian Federation
Vladimir V. Bessonov - Dr. of Sci. (Bio.), head of the laboratory of food chemistry, Federal State Budgetary Institution of Science “Federal Research Center for Nutrition and Biotechnology”.
2/14, Ustinsky Proezd, Moscow, 109240.
M. M. Korosteleva
Russian Federation
Margarita M. Korosteleva - Cand. of Sci. (Med.), Senior Researcher of the Laboratory of Sport Anthropology and Nutrition, Federal State Budgetary Institution of Science “Federal Research Center for Nutrition and Biotechnology”.
2/14, Ustinsky passage, Moscow, 109240.
K. G. Gurevich
Russian Federation
Konstantin G. Gurevich - Dr. of Sci. (Med.), Professor, Head of the UNESCO Chair “Healthy Lifestyle - the Key to Successful Development”, Federal State Budgetary Educational Institution of Higher Education “A.I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Health of the Russian Federation.
20, bldg. 1, Delegateskaya St., Moscow, 127473.
N. P. Lagutina
Russian Federation
Natal'ya P. Lagutina - gastroenterologist, Federal State Budgetary Scientific Institution “Izmerov Research Institute of Occupational Health”.
31, Prospect Budennogo, Moscow, 105275.
R. A. Khanferyan
Russian Federation
Roman A. Khanferyan - Dr. of Sci. (Med.), professor, Federal State Autonomous Educational Institution of Higher Education “Peoples' Friendship University of Russia”.
6, Miklukho-Maklai St., Moscow, 117198.
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Review
For citations:
Pilat TL, Kuzmina LP, Lashina EL, Kolyaskina MM, Bezrukavnikova LM, Bessonov VV, Korosteleva MM, Gurevich KG, Lagutina NP, Khanferyan RA. Experience of application of specialized food product of dietary therapeutic and dietary preventive nutrition in case of inflammatory diseases of gastrointestinal tract. Meditsinskiy sovet = Medical Council. 2020;(4):107-113. (In Russ.) https://doi.org/10.21518/2079-701X-2020-4-107-113