Nimesulide in modern clinical practice: old friends are best
https://doi.org/10.21518/2079-701X-2014-5-82-91
Abstract
Pain control is one of the major problems in clinical practice. The modern concept of analgesic therapy is based on an integrated approach, reliable knowledge of the pain pathogenesis and the use of medications with different mechanisms of action. First-line drugs here are nonsteroidal anti-inflammatory drugs (NSAIDs). In Russia, Nimesulide is considered to be the number one drug in its group which has been used in the domestic clinical practice for more than 15 years. Over the years, Nimesulide was thoroughly studied in numerous clinical trials which proved its efficacy and good tolerability. This review highlights the benefits of Nimesulide distinguishing it from other representatives of the NSAID group.
About the Author
A. E. Karateyev
Research Institute of Rheumatology named after VA Nasonova RAMS
Russian Federation
Russian Federation
References
1. Насонов Е.Л., Насонова В.А. Фармакотерапия боли: взгляд ревматолога. Consilium medicum, 2000, 2 (12): 7-14.
2. Боль (практическое руководство для врачей). Под ред. Яхно Н.Н., Кукушкина М.Л., М.: Издательство РАМН, 2012.
3. Blondell RD, Azadfard M, Wisniewski AM. Pharmacologic therapy for acute pain. Am Fam Physician, 2013, Jun, 1, 87 (11): 766-72.
4. Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther., 2013, 15 (Suppl. 3): S2. doi: 10.1186/ar4174. Epub 2013 Jul 24.
5. Каратеев А.Е., Алексеева Л.И., Филатова Е.Г. и др. Обезболивающие препараты в терапевтической практике. М.: ИМА-ПРЕСС, 2013.
6. Барскова В.Г. Письмо редактора. Совр. Ревматол., 2011, 2: 82-83.
7. Алексеева Л.И., Каратеев А.Е., Попкова ТВ. и др. Эффективность и безопасность длительного применения нимесулида у больных остеоартрозом: результаты 12-ти месячного открытого контролируемого исследования ДИНАМО (Длительное Использование Нимесулида при Артрозе Многофакторная Оценка). Научно-практическая ревматология, 2009, 4: 64-72.
8. drugs.com [интернет] U.S. Pharmaceutical Sales - 2013 [доступ 02.03.2014]. URL: http://www.drugs.com/stats/top100/2013/units
9. Mattia C, Ciarcia S, Muhindo A, Coluzzi F. Nimesulide: 25 years later. Minerva Med., 2010, 101(4): 285-293.
10. Насонов Е.Л. Эффективность и переносимость нестероидного противовоспалительного препарата. Нимесулид: новые данные. РЫЖ, 2001, 15: 6-8.
11. Rainsford K. Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide. Inflammopharmacology, 2006, 14(3-4): 120-137.
12. Bennett A. Nimesulide a well established cyclooxygenase-2 inhibitor with many other pharmacological properties relevant to inflammatory diseases. In: Therapeutic Roles of Selective COX-2 Inhibitors. Editors Vein J.R., Botting R.M., William Harvey Press: 524-540.
13. Camu F. The role of COX-2 inhibitors in pain modulation. Drug, 2003, 63 (suppl.): 1-7.
14. Mehta V, Johnston A, Cheung R et al. Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system. Clin Pharmacol Ther., 2008, 83 (3): 430-435.
15. Dembo G, Park S, Kharasch E. Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.Anesthesiology, 2005, 102 (2): 409-415.
16. McCrory C, Fitzgerald D. Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2. Chest, 2004, 125 (4): 1321-1327.
17. Tassorelli C, Greco R, Sandrini G, Nappi G. Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. Drugs, 2003, 63 (Suppl. 1): 9-22.
18. Bianchi M, Martucci C, Ferrario P et al. Increased Tumor Necrosis Factor- and Prostaglandin E2 Concentrations in the Cerebrospinal Fluid of Rats with Inflammatory Hyperalgesia: The Effects of Analgesic Drugs. AnestAnalg, 2007, 104: 949-954.
19. Binning A. Nimesulide in the treatment of postoperative pain: a double-blind, comparative study in patients undergoing arthroscopic knee surgery. Clin J Pain., 2007, 23 (7): 565-570.
20. Wober W, Rahlfs V, Buchl N et al. Comparative efficacy and safety of the non-steroidal anti-inflammatory drugs nimesulide and diclofenac in patients with acute subdeltoid bursitis and bicipital tendinitis. Int J ClinPract., 1998, 52 (3), 169-175.
21. Pohjolainen T, Jekunen A., Autio L., Vuorela H. Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen. Spine, 2000, 25 (12): 1579-1585.
22. Konstantinovic L, Kahjun Z, Milovanovic A et al. Acute low back pain with radiculopathy: a double - blind, randomized, placebo-controlled study. Photomed laser surg., 2010, 28 (4): 555-560.
23. Lucker P., Pawlowski C., Friedrich I., et al. Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee. Eur J Rheumatol Inflamm, 1994, 14 (2): 29-38.
24. Huskisson E, Macciocchi A, Rahlfs V et al. Nimesulide versus diclofenac in the treatment of osteoarthritis of the hip or knee: an active controlled equivalence study Curr Ther Res, 1999, 60: 253-265.
25. Kriegel W, Korff K, Ehrlich J et al. Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. Int J Clin Pract., 2001, 55 (8): 510-514.
Review
For citations:
Karateyev AE. Nimesulide in modern clinical practice: old friends are best. Meditsinskiy sovet = Medical Council. 2014;(5):82-91. (In Russ.) https://doi.org/10.21518/2079-701X-2014-5-82-91
Views:
562
Email this article 