The maternal factors of failures and defects of implantation after IVF

Introduction. Failures and defects of implantation after IVF are to high extent determined by maternal factors, which are manageable. However, until now, medical tactics have not been clearly defined in identifying the most significant of them among patients who have failures and defects in implantation in previous IVF programs.

Objective. To summarize research literature and results of many years of our own research to determine medical tactics in patients with failures and defects in implantation in previous IVF programs when identifying significant maternal risk factors.

Material and methods. The analysis and collation of data have been performed on the basis of 80 literature sources with a focus on the papers of domestic authors, including publications with regard to their own study results.

Results. The most significant maternal risk factors for failures and defects of implantation after IVF were identified: chronic endomyometritis and thrombophilia. The pregravid preparation algorithm has been determined in patients with chronic endometritis and with previous failures and defects in implantation after IVF, including the use of antibacterial, antiviral, anti-inflammatory, immunomodulating and physiotherapy. We show the necessity for the prescription of low molecular weight heparins in patients with thrombophilia since the establishment of pregnancy after IVF has been shown.

Conclusion. Carrying out pregravid preparation in patients with chronic endometritis and prescribing low molecular weight hepa-rins from early pregnancy in patients with thrombophilia can increase the percentage of women who have become pregnant after IVF and have passed the embryonic threshold.

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