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Analysis of risk factors for vitamin D deficiency by results of the first stage of Russian non-interventional register study

https://doi.org/10.21518/2079-701X-2021-7-109-118

Abstract

Introduction. In Russian Federation, there are no comprehensive studies assessing the quality of life and risk factors for vitamin D deficiency and insufficiency, taking into account its status in different geographic latitudes.

Aim. To assess the quality of life and risk factors for vitamin D deficiency and insufficiency among the population living in the regions of the Russian Federation located at latitudes from 45 ° to 70 °.

Materials and methods. The first stage of the Russian multicenter non-interventional registry study using the “cross-sectional” method was carried out from March 2020 to May 2020.

Results and discussion. According to the results of the correlation analysis, qualitative and quantitative factors were identified, presumably being risk factors for vitamin D deficiency and deficiency. Qualitative risk factors include: education; alcohol consumption; being in direct sunlight for more than 30 minutes a day; visit to the solarium; using sunscreen; drinking coffee; taking medications (not vitamin-mineral complexes). Quantitative factors include: visits to specialists (total per year); smoking (duration, years); exercise for more than 30 minutes a day, once a week; being in direct sunlight for more than 30 minutes a day.

Conclusion. A wide range of risk factors for vitamin D deficiency dictates the need for their further study to clarify the category of persons who are shown targeted biochemical screening with subsequent drug correction.

About the Authors

L. A. Suplotova
Tyumen State Medical University
Russian Federation

Lyudmila A. Suplotova - Dr. Sci. (Med.), Professor, Head of Endocrinology Course, Therapy Department, Institute of Continuing Professional Development,Tyumen State Medical University.

54, Odesskaya St., Tyumen, 625023.



V. A. Avdeeva
Tyumen State Medical University
Russian Federation

Valeria A. Avdeeva - Endocrinologist, Tyumen State Medical University.

54, Odesskaya St., Tyumen, 625023.



L. Y. Rozhinskaya
National Medical Research Center for Endocrinology
Russian Federation

Liudmila Y. Rozhinskaya - Dr. Sci. (Med.), Professor, Lead Research Associate, Department of Neuroendocrinology and Osteopathy, National Medical Research Center for Endocrinology.

11, Dmitry Ulyanov St., Moscow, 117036.



E. A. Pigarova
National Medical Research Center for Endocrinology
Russian Federation

Ekaterina A. Pigarova - Dr. Sci. (Med.), Lead Research Associate, Department of Neuroendocrinology and Osteopathy, Director of Institute of Higher and Continuing Professional Education, National Medical Research Center for Endocrinology.

11, Dmitry Ulyanov St., Moscow, 117036.



E. A. Troshina
National Medical Research Center for Endocrinology
Russian Federation

Ekaterina A. Troshina - Corr. Member RAS, Dr. Sci. (Med.), Professor, Deputy Director of the Center - Director of Institute of Clinical Endocrinology, National Medical Research Center for Endocrinology.

11, Dmitry Ulyanov St., Moscow, 117036.



References

1. Gromova O.A., Torshin I.Yu. Vitamin D - A Paradigm Shift. Moscow: GEOTARMedia; 2017. 576 p. (In Russ.) Available at: https://www.rosmedlib.ru/book/ISBN9785970440582.html.

2. Hossein-nezhad A., Spira A., Holick M.F. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial. PLoS ONE. 2013;8(3):e58725. doi: 10.1371/journal.pone.0058725.

3. Lesnyak O.M. Prevention, Diagnosis and Treatment of Vitamin D and Calcium Deficiencies in Adults and in Patients with Osteoporosis. Moscow: GEOTARMedia; 2016. 96 p. (In Russ.) Available at: https://www.rosmedlib.ru/book/ISBN9785970436790.html.

4. Gaksch M., Jorde R., Grimnes G., Joakimsen R., Schirmer H., Wilsgaard T. et al. Vitamin D and Mortality: Individual Participant Data Meta-Analysis of Standardized 25-Hydroxyvitamin D in 26916 Individuals from a European Consortium. PLoS ONE. 2017;12(2):e0170791. doi: 10.1371/journal.pone.0170791.

5. Tagliabue E., Raimondi S., Gandini S. Vitamin D, Cancer Risk, and Mortality. Adv Food Nutr Res. 2015;75:1-52. doi: 10.1016/bs.afnr.2015.06.O03.

6. Al Mheid I., Quyyumi A.A. Vitamin D and Cardiovascular Disease: Controversy Unresolved. J Am Coll Cardiol. 2017;70:89-100. doi: 10.1016/j.jacc.2017.05.031.

7. Berridge M.J. Vitamin D Deficiency and Diabetes. Biochem J. 2017;474(8):1321-1332. doi: 10.1042/bcj20170042.

8. Altieri B., Muscogiuri G., Barrea L., Mathieu C., Vallone C.V., Mascitelli L. et al. Does Vitamin D Play a Role in Autoimmune Endocrine Disorders? A Proof of Concept. Rev Endocr Metab Disord. 2017;18(3):335-346. doi: 10.1007/s11154-016-9405-9.

9. Fung J.L., Hartman T.J., Schleicher R.L., Goldman M.B. Association of Vitamin D Intake and Serum Levels with Fertility: Results from the Lifestyle and Fertility Study. Fertil Steril. 2017;108(2):302-311. doi: 10.1016/j.fertnstert.2017.05.037.

10. Kodentsova V.M., Mendel O.I., Khotimchenko S.A., Baturin A.K. Nikityuk D.B., Tutelyan V.A. Physiological Need and Effective Doses of Vitamin D to Correct Its Deficiency: Current State of the Problem. Voprosy pitani-ya = Problems of Nutrition. 2017;86(2):47-62. (In Russ.) doi: 10.24411/0042-8833-2017-00033.

11. Zazerskaya I.E., Dorofeykov V.V., Kuznetsova L.V., Khazova E.L., Novikova T.V., Belyaeva E.N. et al. Vitamin D and Reproductive Health of Women. St Petersburg: Eko-Vector; 2017. 151 p. (In Russ.).

12. Petrushkina A.A., Pigarova E.A., Rozhinskaya L.Y. The Prevalence of Vitamin D Deficiency in Russian Federation. Osteoporoz i osteopatii = Osteoporosis and Bone Diseases. 2018;(3):15-20. (In Russ.) doi: 10.14341/osteo10038.

13. Suplotova L.A., Avdeeva V.A., Rozhinskaya L.Y. Vitamin D Status in Residents of Tyumen Region. Ozhirenie i metabolizm = Obesity and Metabolism. 2019;(2):69-74. (In Russ.) doi: 10.14341/omet10162.

14. Karonova T.L., Globa P.Yu., Andreeva A.T., Shishkin S.A., Budanova M.V., Bayramov A.A. Vitamin D Supply and Body Composition in Athletes. Osteoporoz i osteopatii = Osteoporosis and Bone Diseases. 2016;(2):43. (In Russ.) doi: 10.14341/osteo2016243-43.

15. Wacker M., Holick M.F. Sunlight and Vitamin D: A Global Perspective for Health. Dermatoendocrinol. 2013;5(1):51-108. doi: 10.4161/derm.24494.

16. Diehl J.W., Chiu M.W. Effects of Ambient Sunlight and Photoprotection on Vitamin D Status. Dermatol Ther. 2010;23(1):48-60. doi: 10.1111/j.1529-8019.2009.01290.x.

17. Engelsen O., Brustad M., Aksnes L., Lund E. Daily Duration of Vitamin D Synthesis in Human Skin with Relation to Latitude, Total Ozone, Altitude, Ground Cover, Aerosols and Cloud Thickness. Photochem Photobiol. 2005;81(6):1287-1290. doi: doi: 10.1562/2004-11-19-rn-375.

18. Matsuoka L.Y., Ide L., Wortsman J., MacLaughlin J.A., Holick M.F. Sunscreens Suppress Cutaneous Vitamin D3 Synthesis. J Clin Endocrinol Metab. 1987;64(6):1165-1168. doi: 10.1210/jcem-64-6-1165.

19. Pigarova E.A., Rozhinskaya L.Ya., Belaya Zh.E., Dzeranova L.K., Karonova T.L., Il'in A.V., Mel'nichenko G.A., Dedov I.I. Russian Association of Endocrinologists Recommendations for Diagnosis, Treatment and Prevention of Vitamin D Deficiency in Adults. Problemy endokrinologii = Problems of Endocrinology. 2016;62(4):60-84. (In Russ.) doi: 10.14341/probl201662460-84.

20. Lim H.S., Lee H.H., Byun D.W., Lee B., Enkhbold T., Kim T.H. Serum Vitamin D Level Related to Coffee Consumption in Korean Young Adults Using the 5th Korea National Health and Nutrition Examination Survey. J Bone Metab. 2017;24(4):229-233. doi: 10.11005/jbm.2017.24.4.229.

21. Malesa-Ciecwierz M., Usydus Z. Vitamin D: Can Fish Food-Based Solutions Be Used for Reduction of Vitamin D Deficiency in Poland? Nutrition. 2015;31(1):187-192. doi: 10.1016/j.nut.2014.07.003.

22. Nwosu B.U., Kum-Nji P. Tobacco Smoke Exposure Is an Independent Predictor of Vitamin D Deficiency in US Children. PLoS ONE. 2018;13(10):e0205342. doi: 10.1371/journal.pone.0205342.

23. Banihosseini S.Z., Baheiraei A., Shirzad N., Heshmat R., Mohsenifar A. The Effect of Cigarette Smoke Exposure on Vitamin D Level and Biochemical Parameters of Mothers and Neonates. J Diabetes Metab Disord. 2013;12(1):19. doi: 10.1186/2251-6581-12-19.

24. Hermann A.P., Brot C., Gram J., Kolthoff N., Mosekilde L. Premenopausal Smoking and Bone Density in 2015 Perimenopausal Women. J Bone Miner Res. 2000;15(4):780-787. doi: 10.1359/jbmr.2000.15.4.780.

25. IDaz-Gomez N.M., Mendoza C., Gonzalez-Gonzalez N.L., Barroso F., Jimenez-Sosa A., Domenech E. et al. Maternal Smoking and the Vitamin D-Parathyroid Hormone System During the Perinatal Period. J Pediatr. 2007;151(6):618-623. doi: 10.1016/j.jpeds.2007.05.003.

26. Cutillas-Marco E., Fuertes-Prosper A.,Grant W.B.,Morales-Suarez-Varela M. Vitamin D Deficiency in South Europe: Effect of Smoking and Aging. Photodermatol Photoimmunol Photomed. 2012;28(3):159-161. doi: 10.1111/j.1600-0781.2012.00649.x.

27. Manavi K.R., Alston-Mills B.P., Thompson M.P., Allen J.C. Effect of Serum Cotinine on Vitamin D Serum Concentrations among American Females with Different Ethnic Backgrounds. Anticancer Res. 2015;35(2):1211-1218. Available at: https://ar.iiarjournals.org/content/35/2/1211.long.

28. Moon J.H., Kong M.H., Kim H.J. Effect of Secondhand Smoking, Determined by Urinary Cotinine Level on Bone Health. Int J Prev Med. 2018;9:14. doi: 10.4103/ijpvm.ijpvm_280_16.

29. Moskovskiy S.N., Dmitriev V.V., Konev V.P., Goloshubina V.V. Changes in Bone Tissue in Chronic Alcohol Intoxication. In: Actual Issues of Forensic Medicine and Expert Practice. Barnaul, Novosibirsk; 2011. Iss. 17. (In Russ.) Available at: http://journal.forens-lit.ru/node/448.

30. Safonova Yu.A. Influence of the Level of Vitamin D Supply on the State of Musculoskeletal Tissue in People over 65 Years Old. Osteoporoz i osteopatii = Osteoporosis and Bone Diseases. 2016;(2):47-48. (In Russ.) doi: 10.14341/osteo2016247-48.

31. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P. et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930. doi: 10.1210/jc.2011-0385.

32. Pereira-Santos M., Costa P.R.F., Assis A.M.O., Santos C.A.S.T., Santos D.B. Obesity and Vitamin D Deficiency: A Systematic Review and Meta-Analysis. Obes Rev. 2015;16(4):341-349. doi: 10.1111/obr.12239.

33. Lagunova Z., Porojnicu A.C., Lindberg F., Hexeberg S., Moan J. The Dependency of Vitamin D Status on Body Mass Index, Gender, Age and Season. Anticancer Res. 2009;29(9):3713-3720. Available at: https://ar.iiarjournals.org/content/29/9/3713.long.

34. Hosseinpour F., Ellfolk M., Norlin M., Wikvall K. Phenobarbital Suppresses Vitamin D3 25-Hydroxylase Expression: A Potential New Mechanism for Drug-Induced Osteomalacia.Biochem Biophys Res Commun. 2007;357(3):603-607. doi: 10.1016/j.bbrc.2007.03.177.


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For citations:


Suplotova LA, Avdeeva VA, Rozhinskaya LY, Pigarova EA, Troshina EA. Analysis of risk factors for vitamin D deficiency by results of the first stage of Russian non-interventional register study. Meditsinskiy sovet = Medical Council. 2021;(7):109-118. (In Russ.) https://doi.org/10.21518/2079-701X-2021-7-109-118

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ISSN 2079-701X (Print)
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