Diabetic neuropathy in combination with deficiency state
https://doi.org/10.21518/2079-701X-2022-16-2-95-99
Abstract
Diabetic polyneuropathy (DPN) is the most common neurological complication of diabetes mellitus. The most common type of DPN is distal symmetric, predominantly sensory, polyneuropathy. Chronic hyperglycemia plays a key role in DPN pathogenesis. It leads to accumulation of advanced glycation end products in tissues, including vasa nevrorum that supply peripheral nerves with oxygen. Thorough diagnostic approach to DPN is crucial for early detection of this condition. Early diagnosis and treatment slow DPN progression rates and leads to symptom reduction. Long-lasting metformin therapy may cause vitamin B deficiency. This article describes a comprehensive approach to the treatment of patient with type 2 diabetes and symptomatic diabetic and vitamin deficiency neuropathy. Apart from DM therapy, the patient received pathogenesis-based therapy of DPN with alpha-lipoic acid and a combination of vitamins B1, B6 and B12. Such pathogenesis-based approach has shown to decrease severity of DPN symptoms and reduce sensory ataxia.
About the Authors
O. E. Zinovyeva
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor of Department of Neurology and Neurosurgery, Sklifosovskiy Institute of Clinical Medicine
8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia
P. D. Egorov
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Clinical Resident of Department of Neurology and Neurosurgery, Sklifosovskiy Institute of Clinical Medicine
8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia
V. N. Novikov
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Student, Sklifosovskiy Institute of Clinical Medicine
8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia
I. M. Lovchev
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Student, Sklifosovskiy Institute of Clinical Medicine
8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia
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Review
For citations:
Zinovyeva OE, Egorov PD, Novikov VN, Lovchev IM. Diabetic neuropathy in combination with deficiency state. Meditsinskiy sovet = Medical Council. 2022;(2):95-99. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-2-95-99
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