Cardiac arrhythmias in patients with bronchial asthma
https://doi.org/10.21518/2079-701X-2022-16-4-163-168
Abstract
Introduction. According to modern data, bronchial asthma (BA) is an independent risk factor for the development of cardiac arrhythmias (CA), and the use of long-acting β2-agonists (LABA) in basic therapy may further increase the risks of CA.
Aim. To study the structure and risk factors of cardiac arrhythmias in patients with bronchial asthma. Materials and methods. A retrospective study included 181 patients aged 69.4 ± 0.8 years, hospitalized for asthma, with the presence a CA in medical documentation.
Results. Among BA patients with CA, supraventricular CA were found in 71.3% (129) patients, ventricular CA in 16.6% (30), combined CA in 12.2% (22). In 52.5% (95) patients, supraventricular extrasystole was detected, in 35.9% (65) – atrial fibrillation, in 28.7% (52) – ventricular extrasystole, in 1.1% (2) – paroxysmal supraventricular tachycardia, in 0.6% (1) – paroxysmal ventricular tachycardia. It was found that supraventricular CA was significantly more frequent among women (χ2 = 5.974, p = 0.05). The severity of BA and the level of control are not related to the type of observed CA (χ2 = 0.755, p = 0.685 and χ2 = 3.003, p = 0.557, respectively).
Discussion. The use of a combination of ICS and LABA in basic BA therapy versus the use of ICS alone does not have a significant effect on the frequency and structure of cardiac arrhythmias (χ2 = 1.172, p = 0.556).
Conclusion. In hospitalized BA patients, supraventricular cardiac arrhythmias are most often detected, among which supraventricular extrasystole and atrial fibrillation take the main place.
About the Authors
O. M. UryasevRussian Federation
Oleg M. Uryasev, Dr. Sci. (Med.), Professor, Head
9, Vysokovoltnaya St., Ryazan, 390013
A. V. Shakhanov
Russian Federation
Anton V. Shakhanov, Cand. Sci. (Med.), Associate Professor of the Department
9, Vysokovoltnaya St., Ryazan, 390013
I. Yu. Sudakova
Russian Federation
Irina Yu. Sudakova, Assistant of the Departmen
9, Vysokovoltnaya St., Ryazan, 390013
L. V. Korshunova
Russian Federation
Ludmila V. Korshunova, Cand. Sci. (Med.), Associate Professor
9, Vysokovoltnaya St., Ryazan, 390013
V. P. Sidorova
Russian Federation
Viktoria P. Sidorova, Physician
3а, Internatsinalnaya St., Ryazan, 390039
References
1. Heck S., Al-Shobash S., Rapp D., Le D.D., Omlor A., Bekhit A. et al. High probability of comorbidities in bronchial asthma in Germany. NPJ Prim Care Respir Med. 2017;27(1):28. https://doi.org/10.1038/s41533-017-0026-x.
2. Weatherburn C.J., Guthrie B., Mercer S.W., Morales D.R. Comorbidities in adults with asthma: Population-based cross-sectional analysis of 1.4 million adults in Scotland. Clin Exp Allergy. 2017;47(10):1246–1252. https://doi.org/10.1111/cea.12971.
3. Трибунцева Л.В., Будневский А.В., Иванчук Ю.С., Шкатова Я.С., Токмачев Р.Е. Коморбидная патология у пациентов с бронхиальной астмой: обзор литературы. Наука молодых (Eruditio Juvenium). 2021;9(1):136–146. https://doi.org/10.23888/HMJ202191136-146.
4. Chen C.-C., Lin C.-H., Hao W.-R., Chiu C.-C., Fang Y.-A., Liu J.-C., Sung L. Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study. npj Prim Care Respir Med. 2021;31(1):8. https://doi.org/10.1038/s41533-021-00221-3.
5. Nanda A., Wasan A.N. Asthma in Adults. Med Clin North Am. 2020;104(1):95–108. https://doi.org/10.1016/j.mcna.2019.08.013.
6. Chapman K.R., An L., Bosnic-Anticevich S., Campomanes C.M., Espinosa J., Jain P. et al. Asthma patients’ and physicians’ perspectives on the burden and management of asthma. Respir Med. 2021;186:106524. https://doi.org/10.1016/j.rmed.2021.106524.
7. Трибунцева Л.В., Будневский А.В., Шкатова Я.С., Иванчук Ю.С., Токмачев Р.Е. Значение физической активности для клинического течения бронхиальной астмы: обзор литературы. Российский медикобиологический вестник им. академика И.П. Павлова. 2021;29(1):161–170. https://doi.org/10.23888/PAVLOVJ2021291161-170.
8. Di Raimondo D., Musiari G., Benfante A., Battaglia S., Rizzo G., Tuttolomondo A. et al. Prevalence of Arterial Hypertension and Characteristics of Nocturnal Blood Pressure Profile of Asthma Patients According to Therapy and Severity of the Disease: The BADA Study. Int J Environ Res Public Health. 2020;17(18):6925. https://doi.org/10.3390/ijerph17186925.
9. Шапошник И.И., Генкель В.В., Кузнецова А.С., Лебедев Е.В., Салашенко А.О. Нарушения ритма сердца при некоторых заболеваниях внутренних органов (обзор литературы). Сибирский научный медицинский журнал. 2019;39(5):29–40. https://doi.org/10.15372/SSMJ20190504.
10. Dayal P., Iribarren C., Cheung D., Rothenberg M.E., Spain C.V. Rates of Major Cardiovascular Events in Severe Asthma: U.S. Real-World and Clinical Trial–Eligible Populations. Ann Am Thorac Soc. 2021;18(9):1580–1584. https://doi.org/10.1513/AnnalsATS.202010-1349RL.
11. Chamberlain A.M., Boyd C.M., Manemann S.M., Dunlay S.M., Gerber Y., Killian J.M. et al. Risk Factors for Heart Failure in the Community: Differences by Age and Ejection Fraction. Am J Med. 2020;133(6):e237-e248. https://doi.org/10.1016/j.amjmed.2019.10.030.
12. Tiotiu A., Novakova P., Kowal K., Emelyanov A., Chong-Neto H., Novakova S. et al. Beta-blockers in asthma: myth and reality. Expert Rev Respir Med. 2019;13(9):815–822. https://doi.org/10.1080/17476348.2019.1649147.
13. Taha M., Mishra T., Shokr M., Sharma A., Taha M., Samavati L. Burden and impact of arrhythmias in asthma-related hospitalizations: Insight from the national inpatient sample. J Arrhythmia. 2021;37(1):113–120. https://doi.org/10.1002/joa3.12452.
14. Buja A., Bardin A., Grotto G., Elvini S., Gallina P., Zumerle G. et al. How different combinations of comorbidities affect healthcare use by elderly patients with obstructive lung disease. NPJ Prim Care Respir Med. 2021;31(1):30. https://doi.org/10.1038/s41533-021-00242-y.
15. Cazzola M., Calzetta L., Bettoncelli G., Cricelli C., Romeo F., Matera M.G. et al. Cardiovascular disease in asthma and COPD: a population-based retrospective cross-sectional study. Respir Med. 2012;106(2):249–256. https://doi.org/10.1016/j.rmed.2011.07.021.
16. Shah S.R., Park K., Alweis R. Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence. Curr Probl Cardiol. 2019;44(3):92–106. https://doi.org/10.1016/j.cpcardiol.2018.04.002.
17. Tattersall M.C., Guo M., Korcarz C.E., Gepner A.D., Kaufman J.D., Liu K.J. et al. Asthma predicts cardiovascular disease events: the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(6):1520–1525. https://doi.org/10.1161/ATVBAHA.115.305452.
18. Chang Y.-L., Ko H.-K., Lu M.-S., Chou C.-L., Su K.-C., Hsu C.-C. et al. Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan. npj Prim Care Respir Med. 2020;30(1):7. https://doi.org/10.1038/s41533-020-0164-4.
19. Bozkurt Yilmaz H.E., Yilmaz M., Şen N., Altin C., Ünsal Z.E., Tekin A. et al. Assessment of atrial fibrillation and ventricular arrhythmia risk in patients with asthma by P wave/corrected QT interval dispersion. Eur Rev Med Pharmacol Sci. 2018;22(3):756–762. https://doi.org/10.26355/eurrev_201802_14308.
20. Cepelis A., Brumpton B.M., Malmo V., Laugsand L.E., Loennechen J.P., Ellekjær H. et al. Associations of Asthma and Asthma Control With Atrial Fibrillation Risk: Results From the Nord-Trøndelag Health Study (HUNT). JAMA Cardiol. 2018;3(8):721–728. https://doi.org/10.1001/jamacardio.2018.1901.
21. Chan W.-L., Yang K.-P., Chao T.-F., Huang C.-C., Huang P.-H., Chen Y.-C. et al. The association of asthma and atrial fibrillation--a nationwide population-based nested case-control study. Int J Cardiol. 2014;176(2):464–469. https://doi.org/10.1016/j.ijcard.2014.07.087.
22. Tattersall M.C., Dasiewicz A.S., McClelland R.L., Gepner A.D., Kalscheur M.M., Field M.E. et al. Persistent Asthma Is Associated With Increased Risk for Incident Atrial Fibrillation in the MESA. Circ Arrhythm Electrophysiol. 2020;13(2):e007685. https://doi.org/10.1161/CIRCEP.119.007685.
23. Xing G., Woo A.Y.-H., Pan L., Lin B., Cheng M.-S. Recent Advances in β 2-Agonists for Treatment of Chronic Respiratory Diseases and Heart Failure. J Med Chem. 2020;63(24):15218–15242. https://doi.org/10.1021/acs.jmedchem.0c01195.
24. Gunathilaka P.K.G., Punchihewa P.M.G., Kitulwatte N.C., Athukorala T.J., Kankananarachchi I., Fernando C.M.P. et al. Does intravenous salbutamol therapy cause cardiac toxicity in children with acute severe asthma? Sri Lanka J Child Heal. 2016;45(4):250. https://doi.org/10.4038/sljch.v45i4.8055.
25. Kim L.H.Y., Saleh C., Whalen-Browne A., O’Byrne P.M., Chu D.K. Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma. JAMA. 2021;325(24):2466. https://doi.org/10.1001/jama.2021.7872.
26. Scosyrev E., van Zyl-Smit R., Kerstjens H., Gessner C., Kornmann O., Jain D. et al. Cardiovascular safety of mometasone/indacaterol and mometasone/ indacaterol/glycopyrronium once-daily fixed-dose combinations in asthma: pooled analysis of phase 3 trials. Respir Med. 2021;180:106311. https://doi.org/10.1016/j.rmed.2021.106311.
27. Gibb A., Yang L.P.H. Olodaterol: First Global Approval. Drugs. 2013;73(16):1841–1846. https://doi.org/10.1007/s40265-013-0137-9.
28. Andreas S., Bothner U., de la Hoz A., Kloer I., Trampisch M., Alter P. No Influence on Cardiac Arrhythmia or Heart Rate from Long-Term Treatment with Tiotropium/Olodaterol versus Monocomponents by Holter ECG Analysis in Patients with Moderate-to-Very-Severe COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:1945–1953. https://doi.org/10.2147/COPD.S246350.
29. Adimadhyam S., Schumock G.T., Walton S., Joo M., McKell J., Lee T.A. Risk of Arrhythmias Associated with Ipratropium Bromide in Children, Adolescents, and Young Adults with Asthma: A Nested Case-Control Study. Pharmacother J Hum Pharmacol Drug Ther. 2014;34(4):315–323. https://doi.org/10.1002/phar.1336.
30. Battaglia S., Basile M., Spatafora M., Scichilone N. Are asthmatics enrolled in randomized trials representative of real-life outpatients? Respiration. 2015;89(5):383–389. https://doi.org/10.1159/000375314.
Review
For citations:
Uryasev OM, Shakhanov AV, Sudakova IY, Korshunova LV, Sidorova VP. Cardiac arrhythmias in patients with bronchial asthma. Meditsinskiy sovet = Medical Council. 2022;(4):163-168. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-4-163-168