Efficacy of probiotics for the treatment of irritable bowel syndrome
https://doi.org/10.21518/2079-701X-2022-16-15-119-126
Abstract
A review of current literature data was made, substantiating the high prevalence and social significance of irritable bowel syndrome (IBS). In different regions of the world, the prevalence of IBS ranges from 10% to 15%. The pathogenesis of IBS is a multifactorial process, including dysmotility, sluggish immune inflammation, changes in intestinal permeability, dysbiosis, exposure to infectious agents, malnutrition, neurohumoral dysregulation, changes in the central nervous system (psychological stress, cognitive dysfunction) in combination with genetic factors. The complexity of the pathogenesis determines the heterogeneity of the clinical manifestations of IBS, among which there may be forms with a predominance of pain, constipation, diarrhea, flatulence, which in turn complicates approaches to the treatment of this disease. The decisive importance of fecal dysbiosis for the pathogenesis of functional bowel pathology is now recognized. A 2019 systematic review showed a clear decrease in the genera Bifidobacterium and Faecalibacterium, an increase in the families Lactobacillaceae, Enterobacteriaceae and the genus Bacteroides in patients with IBS compared with healthy individuals. The Rome IV criteria, the recommendations of the British Society of Gastroenterology, the United European Gastroenterology and the European Society for Neurogastroenterology and Motility, the Russian Gastroenterological Association substantiate the use of probiotics for the treatment of IBS. Placebo-controlled clinical studies confirm the action of Bifidobacterium longum 35624 to normalize the frequency and form of stools, relieve general symptoms, abdominal pain, bloating, and improve the quality of life in patients with IBS. The expert council, held on March 18, 2022 in Moscow, chaired by the chief gastroenterologist of the Ministry of Health of the Russian Federation, Academician of the RAS V.T. Ivashkin, confirmed the effectiveness of probiotics for the treatment of IBS.
About the Authors
V. V. Tsukanov
Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision “Scientific Research Institute of Medical Problems of the North”
Russian Federation
Russian Federation
Vladislav V. Tsukanov, Dr. Sci. (Med.), Professor, Head of the Clinical Department of the Digestive System Pathology of Adults and Children
3g, Partizan Zheleznyak St., Krasnoyarsk, 660022
A. V. Vasyutin
Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision “Scientific Research Institute of Medical Problems of the North”
Russian Federation
Russian Federation
Alexander V. Vasyutin, Cand. Sci. (Med.), Senior Research Fellow of the Clinical Department of the Digestive System Pathology of Adults and Children
3g, Partizan Zheleznyak St., Krasnoyarsk, 660022
Ju. L. Tonkikh
Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision “Scientific Research Institute of Medical Problems of the North”
Russian Federation
Russian Federation
Julia L. Tonkikh, Cand. Sci. (Med.), Leading Research Fellow of the Clinical Department of the Digestive System Pathology of Adults and Children
3g, Partizan Zheleznyak St., Krasnoyarsk, 660022
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For citations:
Tsukanov VV, Vasyutin AV, Tonkikh JL. Efficacy of probiotics for the treatment of irritable bowel syndrome. Meditsinskiy sovet = Medical Council. 2022;(15):119-126. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-15-119-126
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