Preview

Meditsinskiy sovet = Medical Council

Advanced search

Optimizing the management of patients with persistent postural perceptual dizziness and migraine

https://doi.org/10.21518/2079-701X-2022-16-23-94-100

Abstract

Introduction. Dizziness and headache are among the most frequent complaints in neurological practice, which significantly reduce the quality of life of patients, so the development of effective methods of managing patients with persistent postural perceptual vertigo (PPPD) and migraine is an urgent task.

Objective. To study and optimize typical management practices of patients with PPPD and migraine.

Materials and methods. Twenty-two patients aged 39.3 ± 10.2 years with PPPD and migraine according to the diagnostic criteria of the Classification of Vestibular Disorders of the Barany Society were examined. During the study we used Hospital Anxiety and Depression scale, Beck Depression Inventory, State-Trait Anxiety Inventory, clinical otoneurological examination, otoneurological questionnaire, Dizziness Handicap Inventory, videonystagmography. After the diagnosis was made, the patients were prescribed a complex treatment. To relieve an acute attack of vertigo, dimenhydrinate was prescribed, as well as the combined drug cinnarizine 20 mg + dimenhydrinate 40 mg Arlevert, which in a number of studies showed high efficacy and good tolerability. One month later, the patients were examined in the dynamics.

Results. Patients with PPPD had migraine without aura (54%), migraine with aura (14%), and vestibular migraine (32%). The level of anxiety was significantly higher in the group of patients with PPPD and vestibular migraine. There was moderate severity of dizziness in all groups of patients, after one month against the background of ongoing therapy severity of dizziness significantly decreased in all groups. Diagnoses “PPPD” and “vestibular migraine” were not set beforehand in any of the examined patients.

Conclusions. The study showed a low level of diagnosis of PPPD and vestibular migraine. Management of patients with PPPD and migraine requires a complex approach.

About the Authors

E. N. Zastenskaya
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Ekaterina N. Zastenskaya - Рostgraduate Student, Department of Nervous System Diseases and Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University).

11, Bldg. 1, Rossolimo St., Moscow, 119021



L. M. Antonenko
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Lyudmila M. Antonenko - Dr. Sci. (Med.), Professor, Department of Nervous System Diseases and Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University).

11, Bldg. 1, Rossolimo St., Moscow, 119021



References

1. Staab J.P. Persistent Postural-Perceptual Dizziness. Semin Neurol. 2017;40(1):130–137. https://doi.org/10.1055/s-0039-3402736.

2. Staab J.P., Eckhardt-Henn A., Horii A., Jacob R., Strupp M., Brandt T., Bronstein A. Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): consensus document of the committee for the Classification of Vestibular Disorders of the Bárány Society. J Vestib Res. 2017;27(04):191–208. https://doi.org/10.3233/VES-170622.

3. Brandt T. Phobic postural vertigo. Neurology. 1996;46:1515–1519. https://doi.org/10.1212/WNL.46.6.1515.

4. Bittar R. Clinical characteristics of patients with persistent postural – perceptual dizziness. Braz J Otorhinolaryngol. 2015;81(3):276–282. https://doi.org/10.1016/j.bjorl.2014.08.012.

5. Antonenko L.M., Zastenskaya E.N. Persistent postural-perceptual dizziness: current approaches to diagnosis and treatment. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(4):136–140. (In Russ.) https://doi.org/10.14412/2074-2711-2019-4-136-140.

6. Balaban C., Furman J., Staab J. Threat Assessment and Locomotion: Clinical Applications of an Integrated Model of Anxiety and Postural Control. Semin Neurol. 2013;33(03):297–306. https://doi.org/10.1055/s-0033-1356462.

7. Bronstein A.M. Visual vertigo syndrome: clinical and posturography findings. J Neurol Neurosurg Psychiatry. 1995;59(05):472–476. https://doi.org/10.1136/jnnp.59.5.472.

8. Powell G., Derry-Sumner H., Rajenderkumar D., Rushton S., Sumner P. Persistent postural perceptual dizziness is on a spectrum in the general population. Neurology. 2020;94:1–10. https://doi.org/10.1212/WNL.0000000000009373.

9. Сousins S., Kaski D., Сutfield N., Arshad Q., Ahmad H., Gresty M. et al. Predictors of clinical recovery from vestibular neuritis: a prospective study. Ann Clin Transl Neurol. 2017;4:340–346. https://doi.org/10.1002/acn3.386.

10. Cousins S., Сutfield N., Kaski D., Palla A., Seemungal B., Golding J. et al. Visual dependency and dizziness after vestibular neuritis. PLoS ONE. 2014;9(9):e105426. https://doi.org/10.1371/journal.pone.0105426.

11. Guerraz M., Yardley L., Bertholon P., Pollak L., Rudge P., Gresty M.A, Bronstein A.M. Visual vertigo: symptom assessment, spatial orientation and postural control. Brain. 2001;124:1646–1656. https://doi.org/10.1093/brain/124.8.1646.

12. Schniepp R., Wuehr M., Huth S., Pradhan C., Brandt T., Jahn K. Gait characteristics of patients with phobic postural vertigo: effects of fear of falling, attention, and visual input. J Neurol. 2014;261:738–746. https://doi.org/10.1007/s00415-014-7259-1.

13. Brandt T., Dieterich M. Phobischer Attacken Schwankschwindel, ein neues Syndrom? Munch Med Wochenschr. 1986;128:247–250. https://doi.org/10.1007/978-3-662-13375-0_5.

14. Axer H., Finn S., Wassermann A., Guntinas-Lichius O., Klingner C.M., Witte O.W. Multimodal treatment of persistent postural–perceptual dizziness. Brain Behav. 2020;10(12):e01864. https://doi.org/10.1002/brb3.1864.

15. Staab J.P., Ruckenstein M.J. Expanding the differential diagnosis of chronic dizziness. Arch Otolaryngol Head Neck Surg. 2007;133:170–176. https://doi.org/10.1001/archotol.133.2.170.

16. Zhao X.Q. More clinical thoughts for diagnosis and treatment of vertigo/ dizziness. Chin J Med. 2016;55:745. [In Chinese] https://doi.org/10.3760/cma.j.issn.0578-1426.2016.10.001.

17. Eggers S., Neff B., Shepard N., Staab J. Comorbidities in vestibular migraine. J Vestib Res. 2014;24(5–6):387–395. https://doi.org/10.3233/VES-140525.

18. Coebergh J.C. Vestibular migraine and persistent postural-perceptual dizziness. BMJ. 2019;366:l5435. https://doi.org/10.1136/bmj.l5435.

19. Huang T.C., Wang S.J., Kheradmand A. Vestibular migraine: An update on current understanding and future directions. Cephalalgia. 2020;40(1):107–121. https://doi.org/10.1177/0333102419869317.

20. Abu-Arafeh I., Russell G. Paroxysmal vertigo as a migraine equivalent in children: A population-based study. Cephalalgia. 1995;15:22–25. https://doi.org/10.1046/j.1468-2982.1995.1501022.x.

21. Akerman S., Holland P.R., Goadsby P.J. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12:570–584. https://doi.org/10.1038/nrn3057.

22. Halberstadt A.L., Balaban C.D. Organization of projections from the raphe nuclei to the vestibular nuclei in rats. Neuroscience. 2003;120:573–594. https://doi.org/10.1016/s0306-4522(02)00952-1.

23. Furman J.M., Marcus D.A., Balaban C.D. Vestibular migraine: Clinical aspects and pathophysiology. Lancet Neurol. 2013;12:706–715. https://doi.org/10.1016/S1474-4422(13)70107-8.

24. Jacob R.G., Lilienfeld S.O., Furman J.M.R., Durrant J.D., Turner S.M. Panic disorder with vestibular dysfunction: further clinical observations and description of space and motion phobic stimuli. J Anxiety Dis. 1989;3:117–130. https://doi.org/10.1176/ajp.153.4.503.

25. Eagger S., Luxon L.M., Davies R.A., Coelho A., Ron M.A. Psychiatric morbidity in patients with peripheral vestibular disorder: clinical and neurootological study. J Neurol Neurosurg Psychiatry. 1992;55:383–387. https://doi.org/10.1136/jnnp.55.5.383.

26. Pratt R.T.C., McKenzie W. Anxiety states following vestibular disorders. Lancet. 1958;2:347–349. https://doi.org/10.1016/s0140-6736(58)90262-9.

27. Lilienfeld S.O., Jacob R.G., Furman J.M.R. Vestibular dysfunction followed by panic disorder with agoraphobia. J Nerv Ment Dis. 1988;177:700–701. https://doi.org/10.1212/WNL.46.6.1515.

28. Page M.G.R., Gresty M.A. Motorist’s vestibular disorientation syndrome. J Neurol Neurosurg Psychiatry. 1985;84:729–735. https://doi.org/10.1136/jnnp.48.8.729.

29. Marks I.M. Space “phobia”: a pseudo-agoraphobic syndrome. J Neurol Neurosurg Psychiatry. 1981;44:387–391. https://doi.org/10.1002/mdc3.12911.

30. Huppert D., Kunihiro T., Brandt T. Phobic postural vertigo (154 patients): its association with vestibular disorders. J Audiol Med. 1995;4:97–103. Available at: https://keio.pure.elsevier.com/en/publications/phobic-postural-vertigo-154-patients-its-association-with-vestibu.

31. Balaban C.D., Jacob R.G. Background and history of the interface between anxiety and vertigo. J Anxiety Disord. 2001;15(1–2):27–51. https://doi.org/10.1016/s0887-6185(00)00041-4.

32. Kornhuber H.H. For the differential diagnosis of dizziness. Arch Otorhinolaryngol. 1976;212:339–349. https://doi.org/10.1007/BF00453683.

33. Roseli S., Eliane M. Clinical characteristics of patients with persistent postural and perceptual dizziness. Braz J Otorhinolaryngol. 2015;81(3):276–282. https://doi.org/10.1016/j.bjorl.2014.08.012.

34. Brandt T., Huppert D., Dieterich M. Phobic postural vertigo: a first follow-up. J Neurol. 1994;241(4):191–195. https://doi.org/10.1007/BF00863767.

35. Querner V., Krafczyk S., Dieterich M., Brandt T. Patients with somatoform phobic postural vertigo: the more difficult the balance task, the better the balance performance. Neurosci Lett. 2000;285(1):21–24. https://doi.org/10.1016/s0304-3940(00)01008-9.

36. Staab J., Ruckenstein M. Chronic Dizziness and Anxiety: effect of course of illness on treatment outcome. Arch Otolaryngol Head Neck Surg. 2005;131(8):675. https://doi.org/10.1001/archotol.131.8.675.

37. Staab J., Ruckenstein M. Which comes first? Psychogenic dizziness versus otogenic anxiety. Laryngoscope. 2010;113(10):1714–1718. https://doi.org/10.1097/00005537-200310000-00010.

38. Esin R.G., Khaĭrullin I.Kh., Mukhametova E.R., Esin O.R. Persistent postural-perceptual dizziness. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017;117(4):28–33. (In Russ.) https://doi.org/10.17116/jnevro20171174128-33.

39. Lee J.O., Lee E.S., Kim J.S., Lee E.B., Choi B.C., Jeong Y. et al. Altered brain function in persistent postural perceptual dizziness: A study on resting state functional connectivity. Hum Brain Mapp. 2018;39(8):3340–3353. https://doi.org/10.1002/hbm.24080.

40. Antonenko L.M. Psychogenic dizziness. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2):50–54. (In Russ.) https://doi.org/10.14412/2074-2711-2016-2-50-54.

41. Antonenko L.M., Parfenov V.A. Drug therapy for peripheral vestibular vertigo. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(1):106–110. (In Russ.) https://doi.org/10.14412/2074-2711-2017-1-106-110.

42. Zhu R.T., Rompaey V., Ward B.K. The Interrelations Between Different Causes of Dizziness: A conceptual Framework for Understanding Vestibular Disorders. Ann Otol Rhinol Laryngol. 2019;128(9):869–878. https://doi.org/10.1177/0003489419845014.

43. Guze S.B. Diagnostic and statistical manual of mental disorders. 4th ed. (DSM-IV). Am J Psychiatry. 1995;152(8):1228. https://doi.org/10.1176/ajp.152.8.1228.

44. Diukova G.M., Zamergrad M.V., Golubev V.L., Adilova S.M., Makarov S.A., Functional (psychogenic) vertigo. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017;117(6):91-98. (In Russ.) https://doi.org/10.17116/jnevro20171176191-98.

45. Sezier A.E.I., Saywell N., Terry G., Taylor D., Kayes N. Working – age adults ʼperspectives on living with persistent postural – perceptual dizziness: a qualitative exploratory study. BMJ. 2019;9(4):e024326. https://doi.org/10.1136/bmjopen-2018-024326.

46. Bisdorff A.R., Staab J.P., Newman-Toker D.E. Overview of the International Classification of Vestibular Disorders. Neurol Clin. 2015;33:541–550. https://doi.org/10.1016/j.ncl.2015.04.010.

47. Xue H., Chong Y., Jiang Z.D., Ding L., Yang S.L., Wang L. et al. Etiological analysis on patients with vertigo or dizziness. Zhonghua Yi Xue Za Zhi. 2018;98(16):1227–1230. https://doi.org/10.3760/cma.j.issn.0376-2491.2018.16.008.

48. Dieterich M., Staab J.P. Functional dizziness: From phobic postural vertigo and chronic subjective dizziness to persistent postural-perceptual dizziness. Curr Opin Neurol. 2017;30(1):107–113. https://doi.org/10.1097/WCO.0000000000000417.

49. Dieterich M., Staab J.P., Brandt T. Functional (psychogenic) dizziness. Handb Clin Neurol. 2016;139:447–468. https://doi.org/10.1016/B978-0-12-801772-2.00037-0.

50. Godemann F., Siefert K., Hantschke-Brüggemann M., Neu P., Seidl R., Ströhle A.What accounts for vertigo one year after neuritis vestibularis: anxiety or a dysfunctional vestibular organ? J Psychiatr Res. 2005;379:529–534. https://doi.org/10.1016/j.jpsychires.2004.12.006.

51. Heinrichs N., Edler C., Eskens S., Mielczarek M.M., Moschner C. Predicting continued dizziness after an acute peripheral vestibular disorder. Psychosom Med. 2007;69:700–707. https://doi.org/10.1097/PSY.0b013e318151a4dd.

52. Kutay Ö., Akdal G., Keskinoğlu P., Balcı B.D., Alkın T. Vestibular migraine patients are more anxious than migraine patients without vestibular symptoms. J Neurol. 2017;264(1):37–41. https://doi.org/doi:10.1007/s00415-017-8439-6.

53. Staab J.P. Chronic subjective dizziness. Continuum (Minneap Minn). 2012;18(5):1118–1141. https://doi.org/10.1212/01.CON.0000421622.56525.58.

54. Bisdorff A., Von Brevern M., Lempert T., Newman-Toker D.E. Classification of vestibular symptoms: towards an International Classification of Vestibular Disorders. J Vestib Res. 2009;19(1–2):1–13. https://doi.org/10.3233/VES-2009-0343.

55. Staab J.P., Ruckenstein M.J. Expanding the differential diagnosis of chronic dizziness. Arch Otolaryngol Head Neck Surg. 2007;133(02):170–176. https://doi.org/10.1001/archotol.133.2.170.

56. Kessler L., Bognar-Steinberg I., Baumann W., Skurczynski W. Treatment of vestibular vertigo: comparison of a fixed combination of cinnarizine 20mg and dimenhydrinate 40 mg with the 2.5-fold higher dosed active drugs in monotherapy. A prospective, randomized, reference-controlled, two-center, double-blind study. Arch Sensol Neurootol Sci Pract. 2012;7:1–13. https://doi.org/10.2165/11588920-000000000-00000.

57. Pytel J., Nagy G., Toth A., Spellenberg S., Schwarz M., Repassy G. Efficacy and tolerability of a fixed low-dose combination of cinnarizine and dimenhydrinate in the treatment of vertigo: a 4-week, randomized, double-blind, active- and placebo-controlled, parallel-group, outpatient study. Clin Ther. 2007;29(1):84–98. https://doi.org/10.1016/j.clinthera.2007.01.010.

58. Cirek Z., Schwarz M., Baumann W., Novotný M. Efficacy and tolerability of a fixed combination of cinnarizine and dimenhydrinate versus betahistine in the treatment of otogenic vertigo. A double-blind, randomized clinical study. Clin Drug Investig. 2005;25:377–389. https://doi.org/10.2165/00044011-200525060-00003.


Review

For citations:


Zastenskaya EN, Antonenko LM. Optimizing the management of patients with persistent postural perceptual dizziness and migraine. Meditsinskiy sovet = Medical Council. 2022;(23):94-100. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-23-94-100

Views: 1141


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)