A potential inflammatory role of Toll-like receptor-2 in psoriatic arthritis
V. V. Sobolev,
S. N. Chebysheva,
E. V. Denisova,
S. I. Artemуeva,
N. A. Geppe,
A. G. Soboleva,
I. M. Korsunskaya https://doi.org/10.21518/ms2023-044
Abstract
Introduction. Psoriatic arthritis is a chronic inflammatory disease that is characterized by cellular infiltration and production of pro-inflammatory cytokines and can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR2. Studying the TLR2 gene expression patterns can help choose a therapy for patients with psoriatic arthritis.
Aim. To study the pattern of TLR2 gene expression in blood mononuclear cells of patients with psoriatic arthritis to assess its potential pro-inflammatory role.
Materials and methods. Mononuclear cells were isolated from the peripheral blood of 31 patients with plaque psoriasis, 45 patients with psoriatic arthritis and 20 healthy controls. The expression level of the TNF gene was analysed using a real-time PCR method.
Results and discussion. The comparative analysis of the expression levels of patients with psoriatic arthritis and healthy volunteers showed that the expression level of TNF in patients with psoriatic arthritis was 63 times higher than the expression level in healthy volunteers.
Conclusions. A high level of TLR2 gene expression can indicate its role in the inflammatory process and become a marker of possible joint injury in patients with psoriasis.
About the Authors
V. V. Sobolev
Center for Theoretical Problems of Physico-Сhemical Pharmacology of RAS
Russian Federation
Russian Federation
Vladimir V. Sobolev, Cand. Sci. (Biol.), Senior Researcher
30, Srednyaya Кalitnikovskaya St., Moscow, 119991, Russia
S. N. Chebysheva
Clinical Institute of Children’s Health named after N.F. Filatov, Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Svetlana N. Chebysheva, Cand. Sci. (Med.), Associate Professor, Associate Professor of the Department of Children’s Diseases
6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 109029, Russia
E. V. Denisova
Center for Theoretical Problems of Physico-Сhemical Pharmacology of RAS;
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Elena V. Denisova, Cand. Sci. (Med.), Senior Researcher; Deputy Head of the Branch for the Medical Part
30, Srednyaya Кalitnikovskaya St., Moscow, 119991, Russia
17, Leninskiy Ave., Moscow, 119071, Russia
S. I. Artemуeva
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Sofуa I. Artemуeva, Researcher of the Department of Clinical Dermatovenerology and Cosmetology, Dermatovenerologist
17, Leninskiy Ave., Moscow, 119071, Russia
N. A. Geppe
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Natalia А. Geppe, Dr. Sci. (Med.), Professor, Head of the Department of Children’s Diseases of the Clinical Institute of Children’s Health named after N.F. Filatov
6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 109029, Russia
A. G. Soboleva
Center for Theoretical Problems of Physico-Сhemical Pharmacology of RAS; Research Institute of Human Morphology
Russian Federation
Russian Federation
Anna G. Soboleva, Cand. Sci. (Biol.), Senior Researcher, Center for Theoretical Problems of Physico-Сhemical Pharmacology of RAS; Researcher
30, Srednyaya Kalitnikovskaya St., Moscow 109029, Russia
3, Tsurupa St., Moscow, 117418, Russia
I. M. Korsunskaya
Center for Theoretical Problems of Physico-Сhemical Pharmacology of RAS;
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Irina М. Korsunskaya, Dr. Sci. (Med.), Professor, Head of the Laboratory of Physico-Chemical and Genetic Problems of Dermatology; Leading
Researcher
30, Srednyaya Кalitnikovskaya St., Moscow, 119991, Russia
17, Leninskiy Ave., Moscow, 119071, Russia;
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Review
For citations:
Sobolev VV, Chebysheva SN, Denisova EV, Artemуeva SI, Geppe NA, Soboleva AG, Korsunskaya IM. A potential inflammatory role of Toll-like receptor-2 in psoriatic arthritis. Meditsinskiy sovet = Medical Council. 2023;(2):84-88. (In Russ.) https://doi.org/10.21518/ms2023-044
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