Еndoscopic and histological features of the gastroduodenal zone in children with the CagA Helicobacter pylori infection
https://doi.org/10.21518/ms2023-275
Abstract
Introduction. It is known that the presence of the CagA gene in Helicobacter pylori is associated with its increased pathogenicity. However, in children, studies on the effects of this strain on the gastric mucosa are insufficient.
Aim. To compare effects of different Helicobacter pylori (HP) strains on the gastric and duodenum mucosa in children to optimize indications for eradication.
Materials and methods. 397 adolescents (169 boys and 227 girls) aged 11–18 were examined on the basis of the hospital gastroenterological department: the content of antibodies to the CagA strain of HP was determined by ELISA, esophagogastroduodenoscopy (EFGDS) was performedwith a biopsy of the gastric mucosa and determination of the HP contamination degree, and also HP gene was detected in the feces.According to the results obtained, all children were divided into 3 groups: 131 children (57 boys and 74 girls) infected with CagA by negative HP strains (CagA “-”); 119 children (52 boys and 67 girls) infected with CagA positive HP strains (CagA “+”); 94 children (36 boys and 57 girls) who are not infected with HP (HP “-”).
Results. When we analyzed the endoscopic-histological picture of the gastric mucosa in the CagA “+” group, in contrast to the CagA “-” group, it was found that the chances of developing highbacteria contamination of the mucosa increased 4.7 times, II and III degree of gastritis activity – 6.6 times, chronic inflammation – 2.6 times, hyperplastic gastritis – 2.8 times, erosive gastritis or duodenitis – 2.7 times, peptic ulcer – 3.6 times, andalso signs of concomitant candidiasis (the presence of structural elements of the Candida fungus) – 4.1 times.
Conclusion. Thus, it is advisable for all children with gastroduodenal pathology to recommend an examination for the detection of the CagA HP antigen with subsequent eradication.
About the Authors
M. V. ShubinaRussian Federation
Margarita V. Shubina, Junior Researcher, Clinical Department of Children’s Somatic and Mental Health
3g, Partizan Zheleznyak St., Krasnoyarsk, 660022
S. Yu. Tereshchenko
Russian Federation
Sergey Yu. Tereshchenko, Dr. Sci. (Med.), Professor, Head of Clinical Department of Children’s Somatic and Mental Health
3g, Partizan Zheleznyak St., Krasnoyarsk, 660022
N. N. Gorbacheva
Russian Federation
Nina N. Gorbacheva, Senior Researcher Clinical Department of Children’s Somatic and Mental Health
3g, Partizan Zheleznyak St., Krasnoyarsk, 660022
E. N. Anisimova
Russian Federation
Elena N. Anisimova, Cand. Sci. (Med.), Associate Professor, Head of the Department of Clinical Laboratory Diagnostics, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky; Head, Krasnoyarsk Regional Skin and Venereological Dispensary No. 1
1, Partizan Zheleznyak St., Krasnoyarsk, 660022,
79, Bryansk St., Krasnoyarsk, 660099
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Review
For citations:
Shubina MV, Tereshchenko SY, Gorbacheva NN, Anisimova EN. Еndoscopic and histological features of the gastroduodenal zone in children with the CagA Helicobacter pylori infection. Meditsinskiy sovet = Medical Council. 2023;(17):238-245. (In Russ.) https://doi.org/10.21518/ms2023-275