Preview

Meditsinskiy sovet = Medical Council

Advanced search

Origin, diagnostics and treatment of androgen-dependent skin lesions

https://doi.org/10.21518/2079-701X-2014-17-118-127

Abstract

Hirsutism, acne, seborrhea and alopecia in women, according to general opinion, are directly attributed to androgenic metabolic disorders. However, androgen-dependent skin lesions represent a heterogeneous group of diseases and include symptoms of various origin associated with various diseases and conditions, not always consisting in the excess production or action of male hormones in the female body. Whatever the cause of androgen-dependent dermopathy, presence of an obvious cosmetic defect causes trauma to the patient. That is why androgen-dependent dermopathy is a relevant issue. The other facet of its relevance lies in the fact that androgen-dependent symptoms may become the first sign of a serious illness, so they need to be considered by all specialists, not only dermatologists. In fact, the problem of androgen-dependent dermopathy is interdisciplinary and a matter of interest for dermatologists, gynecologists, endocrinologists, psychiatrists and general practitioners.

About the Authors

I. V. Kuznetsova
First Moscow State Medical University named after I.M. Sechenov
Russian Federation


P. A. Nabieva
First Moscow State Medical University named after I.M. Sechenov
Russian Federation


T. I. Romantsova
First Moscow State Medical University named after I.M. Sechenov
Russian Federation


References

1. Pawin H, Beylot C, Chivot M, Faure M, Poli F, Revuz J, Dr no B. Physiopathology of acne vulgaris: recent data, new understanding of the treatments. Eur J Dermatol, 2004, 14(1): 4-12.

2. Schaefer I, Rustenbach SJ, Zimmer L et al. Prevalence of skin diseases in a cohort of 48,665 employees in Germany. Dermatology, 2008, 217(2): 169-172.

3. Stankiewicz M, Norman R. Diagnosis and management of polycystic ovary syndrome: a practical guide. Drugs, 2006, 66: 903-912.

4. Rosenfield RL. Clinical practice. Hirsutism. N Engl J Med, 2005, 353: 2578-2588.

5. Hahn S, Janssen OE, Tan S, Pleger K. Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome. Eur J Endocrinol, 2005, 153: 853-860.

6. Halvorsen JA, Dalgard F, Thoresen M. Is the association between acne and mental distress influenced by diet? Results from a crosssectional population study among 3775 late adolescents in Oslo, Norway BMC Public Health, 2009, 9: 340.

7. Himelein MJ, Thatcher SS. Polycystic ovary syndrome and mental health: A review Obstet GynecolSurv, 2006, 61(11): 723-732.

8. Ching HL, Burke V, Stuckey BGA. Quality of Life and Psychological Morbidity in Women with Polycystic Ovary Syndrome: Body Mass Index, Age and the Provision of Patient Information Are Significant Modifiers. Clin Endocrinol, 2007, 66(3): 373-379.

9. Brinton LA, Moghissi KS, Westhoff CL, Lamb EJ, Scoccia B. Cancer Risk Among Infertile Women with Androgen Excess or Menstrual Disorders (including Polycystic Ovary Syndrome). Fertil Steril, 2010, 94(5): 1787-1792.

10. Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med 2010, 362: 485-493.

11. Yang W, Lu J, Weng J et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010, 362: 1090-1101.

12. Azziz R, Sanchez LA, Knochenhauer ES, et al. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab 2004, 89: 453-462.

13. Miller WL, Auchus RJ. The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders. Endocr Rev 2011, 32(1): 81-151.

14. Nissar AS, Heath JA, Pall M. Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome. J Clin Endocrinol Metab 2008, 93: 1939-1945.

15. Hahn S, Tan S, Elsenbruch S, Quadbeck B, Herrmann BL, Mann K, Janssen OE. Clinical and biochemical characterization of women with polycystic ovary syndrome in North Rhine-Westphalia. Horm Metab Res 2005, 37: 438-444.

16. Quinkler M, Sinha B, Tomlinson JW, Bujalska IJ, Stewart PM, Arlt W. Androgen generation in adipose tissue in women with simple obesity -a site -specific role for 17beta-hydroxysteroid dehydrogenase type 5. J Endocrinol. 2004, 183: 331-342.

17. Ding EL, Song Y, Manson JE, Hunter DJ, Lee CC, Nader R, Buring JE, Gaziano JM, Liu S. Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Women and Men. NEnglJMed. 2009, 361(12): 1152-1163.

18. Hahn S, Haselhorst U, Tan S et al. Low Serum 25-Hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006, 114: 577-583.

19. Patel SM, Ratcliffe SJ, Reilly MP, et al. Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2009, 94(12): 4776-4784.

20. Stener-Victorin E, ran Holm G, Labrie F et al. Are There Any Sensitive and Specific Sex Steroid Markers for Polycystic Ovary Syndrome? J Clin Endocrinol Metab 2010, 95: 810-819.

21. Souter I, Sanchez LA, Perez M, Bartolucci AA, Azziz R The prevalence of androgen excess among patients with minimal unwanted hair growth. Am J Obstet Gynecol 2004, 191: 1914-1920.

22. Takeda N, Jain R, LeBoeuf MR, Padmanabhan A, Wang Q, Li L et al. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development 2013, 140(8): 1655-1664.

23. Yaykasli KO, Turan H, Kaya E, Hatipoglu OF. Polymorphisms in the promoters of MMP-2 and TIMP-2 genes in patients with acne vulgaris. Int J Clin Exp Med 2013,25,6(10): 967-972.

24. James WD. Acne. N EnglJ Med 2005, 352 (14): 1463-1472.

25. Schmitt JV, Masuda PY, Miot HA. Acne in women: clinical patterns in different age-groups. An Bras Dermatol 2009, 84(4).


Review

For citations:


Kuznetsova IV, Nabieva PA, Romantsova TI. Origin, diagnostics and treatment of androgen-dependent skin lesions. Meditsinskiy sovet = Medical Council. 2014;(17):118-127. (In Russ.) https://doi.org/10.21518/2079-701X-2014-17-118-127

Views: 509


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)