Preview

Meditsinskiy sovet = Medical Council

Advanced search

The effect of goat-milk-based formulas on infant health

https://doi.org/10.21518/ms2024-260

Abstract

Breast milk is the “gold standard” for feeding infants for the first years of life and affects the children health both at an early age and in subsequent periods of their life. However, there are times when women are unable to breastfeed for the following reasons: a woman cannot make milk or has health problems, or lose interest in breastfeeding, or should be back at work, etc. This brings up a legitimate question: how to choose among a large number of infant formulas for healthy infants the one that will fit and be safe for a child to use, taking into account their gestational age, as well as a large number of individual “risk facts” such as high or low body mass and height parameters, features of a childbirth (“vaginal”, operative delivery), etc. Most often, the choice falls on cow-milk-based infant formula. After all, one should not forget about alternative options such as goat-milk-based formulas. Historical evidence shows that patients with rickets were fed with goat milk and it was believed to affect brain functions. Interest in the beneficial effects of goat’s milk has been steadily increasing to this day, given that the biological active substances present in goat’s milk are also present in women’s milk in larger quantities. The β-casein fraction is its main component, which makes it as similar to breast milk in structure as possible. In addition to proteins, fats are components that contribute to the excellent digestibility of goat milk. Their distinctive feature is smaller size as compared to milk fats from other animals. This article explores all the benefits of goat milk and its effect on all aspects of infant health.

About the Authors

I. N. Zakharova
Russian Medical Academy of Continuous Professional Education; Children’s City Clinical Hospital named after Z.A. Bashlyaeva
Russian Federation

Irina N. Zakharova, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Pediatrics named after Acad. G.N. Speransky

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

28, Geroyev Panfilovtsev St., Moscow, 125373



N. G. Sugian
Russian Medical Academy of Continuous Professional Education; Khimki Hospital
Russian Federation

Narine G. Sugian, Cand. Sci. (Med.), Associate Professor of the Department of Pediatrics named after Acad. G.N. Speransky; Deputy Chief Physician for Children

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

11, Kurkinskoe Shosse, Khimki, Moscow Region, 141407



Ya. V. Orobinskaya
Russian Medical Academy of Continuous Professional Education; Khimki Hospital, Mother and Baby Outpatient Clinic
Russian Federation

Yana V. Orobinskaya, Postgraduate Student of the Department of Pediatrics named after Academician G.N. Speransky; Pediatrician

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

1, Rodionov St., Khimki, Moscow Region, 141400



References

1. Rodríguez JM. The human milk microbiota. Pediatrics. Consilium Medicum. 2016;(4):35–40. (In Russ.) Available at: https://omnidoctor.ru/library/izdaniyadlya-vrachey/pediatriya-consilium-medicum/ped2016/ped2016_4/mikrobiota-zhenskogo-moloka.

2. Urashima T, Taufik E. Oligosaccharides in milk: their benefits and future utilization. Media Peternakan. 2011;33:189–197. https://doi.org/10.5398/medpet.2010.33.3.189.

3. Sanz Ceballos L, Morales ER, de la Torre Adarve G, Castro JD, Martínez LP, Sanz Sampelayo MR. Composition of goat and cow milk produced under similar conditions and analyzed by identical methodology. J Food Comp Anal. 2009;22:322–329. https://doi.org/10.1016/j.jfca.2008.10.020.

4. Silanikove N, Leitner G, Merin U, Prosser CG. Recent advances in exploiting goat’s milk: quality, safety and production aspects. Small Rumin. Res. 2010;89(2-3):110–124. https://doi.org/10.1016/j.smallrumres.2009.12.033.

5. Becker W, Brasseur D, Bresson J-L, Flynn A, Jackson AA, Lagiou P et al. Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission relating to the evaluation of goats’ milk protein as a protein source for infant formulae and follow-on formulae. EFSA Journal. 2004;30:1–15. https://doi.org/10.2903/j.efsa.2004.30.

6. Agostoni C, Bresson J-L, Fairweather-Tait S, Flynn A, Golly I, Korhonen H et al. Scientific Opinion on the suitability of goat milk protein as a source of protein in infant formulae and in follow-on formulae. EFSA Journal. 2012;10(3):2603. https://doi.org/10.2903/j.efsa.2012.2603.

7. Maryniak NZ, Sancho AI, Hansen EB, Bøgh KL. Alternatives to Cow’s Milk-Based Infant Formulas in the Prevention and Management of Cow’s Milk Allergy. Foods. 2022;11(7):926. https://doi.org/10.3390/foods11070926.

8. Kholodova IN, Titova TA, Kudayarova LR, Kulakova GA, Nechaeva VV, Fetisova TG, Zheltukhina MV. Formulae based on goat’s milk: their possible use in feeding infants during the first months of life. Practical Medicine. 2017;(10):35–42. (In Russ.) Available at: https://www.elibrary.ru/zvhkvf.

9. Amigo L, Fontecha J. Goat milk. In: Fuquay JW, Fox PF, McSweeney PLH (eds.). Encyclopedia of Dairy Sciences. 2nd ed. Elsevier Ltd., Oxford; 2011. Vol. 3, pp. 484–493. https://doi.org/10.1016/B978-0-12-374407-4.00313-7.

10. Muñoz-Salinas F, Andrade-Montemayor HM, De la Torre-Carbot K, Duarte-Vázquez MÁ, Silva-Jarquin JC. Comparative Analysis of the Protein Composition of Goat Milk from French Alpine, Nubian, and Creole Breeds and Holstein Friesian Cow Milk: Implications for Early Infant Nutrition. Animals (Basel). 2022;12(17):2236. https://doi.org/10.3390/ani12172236.

11. Abdulwahid Jaber Al-Fayad M. Evaluation of Different Chemical and Physical Components of Milk in Cows, Buffalos, Sheep, and Goats. Arch Razi Inst. 2022;77(1):477–481. https://doi.org/10.22092/ARI.2021.356861.1932.

12. Jenness R. Composition and characteristics of goat milk: review 1968–1979. Journal of Dairy Science. 1980;63:1605. https://doi.org/10.3168/jds.S00220302(80)83125-0.

13. Remeuf F, Lenoir J. Relationship between the physicochemical characteristics of goat’s milk and its rennetability. Int Dairy Fed Bulletin. 1986;XI(2):68.

14. Park YW. Goat Milk-Chemistry and Nutrition. In: Park YW, Haenlein GFW (eds.). Handbook of Milk of Non-Bovine Mammals. Blackwell Publishers, Oxford; 2006, pp. 34–58. https://doi.org/10.1002/9780470999738.ch3.

15. Berdiyeva A, Charyyev KH. Milk proteins and its fractions. CETERIS PARIBUS. 2023;(1):43–45. (In Russ.) Available at: https://elibrary.ru/bwymjp.

16. Kawaguchi T, Yamagishi S, Sata M. Branched-chain amino acids and pigment epithelium-derived factor: Novel therapeutic agents for hepatitis c virus-associated insulin resistance. Curr Med Chem. 2009;16(36):4843–4857. https://doi.org/10.2174/092986709789909620.

17. Jung TH, Hwang HJ, Yun SS, Lee WJ, Kim JW, Ahn JY et al. Hypoallergenic and Physicochemical Properties of the A2 β-Casein Fractionof Goat Milk. Korean J Food Sci Anim Resour. 2017;37(6):940–947. https://doi.org/10.5851/kosfa.2017.37.6.940.

18. Gantner V, Miji´c P, Baban M, Škrti´c Z, Turalija A. The Overall and Fat Composition of Milk of Various Species. Mljekarstvo. 2015;65(4):223–231. https://doi.org/10.15567/mljekarstvo.2015.0401.

19. Pamukova D, Naydenova N, Mihaylova G. Fatty acid profile and healthy lipid indices of bulgarian goat milk from breeds, pasture-raised in a mountain region. Trakia Journal of Sciences. 2018;16(4):313–319. https://doi.org/10.15547/tjs.2018.04.008.

20. Attaie R, Richter RL. Size Distribution of Fat Globules in Goat Milk. J Dairy Sci. 2000;83(5):940–944. https://doi.org/10.3168/jds.S0022-0302(00)74957-5.

21. Roncada P, Gaviraghi A, Liberatori S, Canas B, Bini L, Greppi GF. Identification of Caseins in Goat Milk. Proteomics. 2002;2(6):723–726. https://doi.org/10.1002/1615-9861(200206)2:6<723::AID-PROT723>3.0.CO;2-I.

22. López-Aliaga I, Alférez MJ, Nestares MT, Ros PB, Barrionuevo M, Campos MS. Goat milk feeding causes an increase in biliary secretion of cholesterol and a decrease in plasma cholesterol levels in rats. J Dairy Sci. 2005;88(3):1024–1030. https://doi.org/10.3168/jds.S0022-0302(05)72770-3.

23. Viladomiu M, Hontecillas R, Bassaganya-Riera J. Modulation of inflammation and immunity by dietary conjugated linoleic acid. Eur J Pharmacol. 2016;785:87–95. https://doi.org/10.1016/j.ejphar.2015.03.095.

24. Chatziioannou AC, Benjamins E, Pellis L, Haandrikman A, Dijkhuizen L, van Leeuwen SS. Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2’-FL Variability. J Agric Food Chem. 2021;69(28):7851–7862. https://doi.org/10.1021/acs.jafc.1c00499.

25. Park YW. Bioactive components in goat milk. In: Park YW (ed.). Bioactive Components in Milk and Dairy Products. Wiley-Blackwell; 2009, pp. 43–81. https://doi.org/10.1002/9780813821504.ch3.

26. van Leeuwen SS, Te Poele EM, Chatziioannou AC, Benjamins E, Haandrikman A, Dijkhuizen L. Goat Milk Oligosaccharides: Their Diversity, Quantity, and Functional Properties in Comparison to Human Milk Oligosaccharides. J Agric Food Chem. 2020;68(47):13469–13485. https://doi.org/10.1021/acs.jafc.0c03766.

27. Han Y, Ma H, Liu Y, Zhao Y, Li L. Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and shortchain fatty acids in the large intestine of the mouse. J Dairy Sci. 2021;104(3):2773–2786. https://doi.org/10.3168/jds.2020-19510.

28. Keunen K, van Elburg RM, van Bel F, Benders MJ. Impact of nutrition on brain development and its neuroprotective implications following preterm birth. Pediatr Res. 2015;77(1-2):148–55. https://doi.org/10.1038/pr.2014.171.

29. Prosser CG. Compositional and functional characteristics of goat milk and relevance as a base for infant formula. J Food Science. 2021;86(2):257–265. https://doi.org/10.1111/1750-3841.15574.

30. Simon PM, Goode PL, Mobasseri A, Zopf D. Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides. Infect Immun. 1997;65(2):750–757. https://doi.org/10.1128/iai.65.2.750-757.1997.

31. Imberty A, Chabre YM, Roy R. Glycomimetics and glycodendrimers as high affinity microbial anti-adhesins. Chemistry. 2008;14(25):7490–7499. https://doi.org/10.1002/chem.200800700.

32. Thum C, Roy NC, McNabb WC, Otter DE, Cookson AL. In Vitro Fermentation of caprine milk oligosaccharides by bifidobacteria isolated from breast-fed infants. Gut Microbes. 2015;6(6):352–363. https://doi.org/10.1080/19490976.2015.1105425.

33. Kiely LJ, Busca K, Lane JA, van Sinderen D, Hickey RM. Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria. FEMS Microbiol Rev. 2023;47(6):fuad056. https://doi.org/10.1093/femsre/fuad056.

34. Quinn EM, Slattery H, Walsh D, Joshi L, Hickey RM. Bifidobacterium longum subsp. ATCC 15697 and Goat Milk Oligosaccharides Show Synergism In Vitro as Anti-Infectives against Campylobacter jejuni. Foods. 2020;9(3):348. https://doi.org/10.3390/foods9030348.

35. Oliveira DL, Costabile A, Wilbey RA, Grandison AS, Duarte LC, Rosinfantiseiro LB. In Vitro Evaluation of the Fermentation Properties and Potential Prebiotic Activity of Caprine Cheese Whey Oligosaccharides in Batch Culture Systems. BioFactors. 2012;38(6):440–449. https://doi.org/10.1002/biof.1043.

36. Thum C, McNabb WC, Young W, Cookson AL, Roy NC. Prenatal caprine milk oligosaccharide consumption affects the development of mice offspring. Mol Nutr Food Res. 2016;60(9):2076–2085. https://doi.org/10.1002/mnfr.201600118.

37. Davis EC, Castagna VP, Sela DA, Hillard MA, Lindberg S, Mantis NJ et al. Gut microbiome and breast-feeding: Implications for early immune development. J Allergy Clin Immunol. 2022;150(3):523–534. https://doi.org/10.1016/j.jaci.2022.07.014.

38. Alférez MJM, López-A liaga I, Nestares T, Díaz-Castro J, Barrionuevo M, Ros PB, Campos MS. Dietary Goat Milk Improves Iron Bioavailability in Rats with Induced Ferropenic Anaemia in Comparison with Cow Milk. Int Dairy J. 2006;16(7):813–821. https://doi.org/10.1016/j.idairyj.2005.08.001.

39. Raynal-Ljutovac K, Lagriffoul G, Paccard P, Guillet I, Chilliard Y. Composition of goat and sheep milk products: an update. Small Rumin Res. 2008;79(1):57–72. https://doi.org/10.1016/j.smallrumres.2008.07.009.

40. Mirzaei H, Sharafati Chaleshtori R. Role of fermented goat milk as a nutritional product to improve anemia. J Food Biochem. 2022;46(6):e13969. https://doi.org/10.1111/jfbc.13969.

41. Basnet S, Schneider M, Gazit A, Mander G, Doctor A. Fresh goat’s milk for infants: myths and realities – a review. Pediatrics. 2010;125(4):e973–e977. https://doi.org/10.1542/peds.2009-1906.

42. Jerop R, Kosgey IS, Ogola TDO, Opondo FA. Consumers’ perceptions towards goat’s milk: Exploring the attitude amongst consumers and its implication for a dairy goat breeding programme in Siaya County, Kenya. Eur J Bus Manag. 2014;6(28):221–229. Available at: https://www.iiste.org/Journals/index.php/EJBM/article/view/16021/16699.

43. de Assis POA, Guerra GCB, de Souza Araújo DF, de Araújo Júnior RF, Machado TADG, de Araújo AA et al. Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis. Int Dairy J. 2016;56:45–54. https://doi.org/10.1016/j.idairyj.2015.11.002.

44. Paturi G, Butts CA, Hedderley D, Stoklosinki H, Martell S, Dinnan H, Carpenter EA. Goat and cow milk powder-based diets with or without prebiotics influence gut microbial populations and fermentation products in newly weaned rats. Food Bioscience. 2018;24:73–79. https://doi.org/10.1016/j.fbio.2018.06.001.

45. Wang Z, Jiang S, Ma C, Huo D, Peng Q, Shao Y, Zhang J. Evaluation of the nutrition and function of cow and goat milk based on intestinal microbiota by metagenomic analysis. Food Funct. 2018;9(4):2320–2327. https://doi.org/10.1039/C7FO01780D.

46. Zhang J, Wang Z, Huo D, Shao Y. Consumption of Goats’ Milk Protects Mice From Carbon Tetrachloride-Induced Acute Hepatic Injury and Improves the Associated Gut Microbiota Imbalance. Front Immunol. 2018;9:1034. https://doi.org/10.3389/fimmu.2018.01034.

47. Butts CA, Paturi G, Hedderley DI, Martell S, Dinnan H, Stoklosinski H, Carpenter EA. Goat and cow milk differ in altering microbiota composition and fermentation products in rats with gut dysbiosis induced by amoxicillin. Food Funct. 2021;12(7):3104–3119. https://doi.org/10.1039/D0FO02950E.

48. Liu Y, Zhang F. Changes of antibiotic resistance genes and gut microbiota after the ingestion of goat milk. J Dairy Sci. 2022;105(6):4804–4817. https://doi.org/10.3168/jds.2021-21325.

49. Ye A, Cui J, Carpenter E, Prosser C, Singh H. Dynamic in vitro gastric digestion of infant formulae made with goat milk and cow milk: Influence of protein composition. Int Dairy J. 2019;97:76–85. https://doi.org/10.1016/j.idairyj.2019.06.002.

50. Jankiewicz M, van Lee L, Biesheuvel M, Brouwer-Brolsma EM, van der Zee L, Szajewska H. The Effect of Goat-Milk-Based Infant Formulas on Growth and Safety Parameters: A Systematic Review and Meta-Analysis. Nutrients. 2023;15(9):2110. https://doi.org/10.3390%2Fnu15092110.

51. Han Y, Chang EY, Kim J, Ahn K, Kim HY, Hwang EM et al. Association of infant feeding practices in the general population with infant growth and stool characteristics. Nutr Res Pract. 2011;5(4):308–312. https://doi.org/10.4162%2Fnrp.2011.5.4.308.

52. Infante DD, Prosser CG, Tormo R. Constipated patients fed goat milk protein formula: A case series study. J Nutr Health Sci. 2018;5(2):203–208. https://doi.org/10.15744/2393-9060.5.203.

53. Wang J, Liu X, Ma H, Yin X, Zhang X, Wen J et al. The evolution of infants’ gut microbiota under different feeding regimes. 2021. Available at: https://ausnutria-nutrition-institute.com/app/uploads/2021/06/6126_AUSNUTRIA_WCPGHAN_Poster_Microbiota_A0_i.pdf.

54. Chen Q, Yin Q, Xie Q, Liu S, Guo Z, Li B. Elucidating gut microbiota and metabolite patterns shaped by goat milk-based infant formula feeding in mice colonized by healthy infant feces. Food Chem. 2023;410:135413. https://doi.org/10.1016/j.foodchem.2023.135413.

55. Han Y, Ma H, Liu Y, Zhao Y, Li L. Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and shortchain fatty acids in the large intestine of the mouse. J Dairy Sci. 2021;104(3):2773–2786. https://doi.org/10.3168/jds.2020-19510.

56. Wang L, Bravo-Ruiseco G, Happe R, He T, van Dijl JM, Harmsen HJM. The effect of calcium palmitate on bacteria associated with infant gut microbiota. Microbiologyopen. 2021;10(3):e1187. https://doi.org/10.1002/mbo3.1187.

57. de Goffau MC, Luopajärvi K, Knip M, Ilonen J, Ruohtula T, Härkönen T et al. Fecal microbiota composition differs between children with β-cell autoimmunity and those without. Diabetes. 2013;62(4):1238–1244. https://doi.org/10.2337/db12-0526.


Review

For citations:


Zakharova IN, Sugian NG, Orobinskaya YV. The effect of goat-milk-based formulas on infant health. Meditsinskiy sovet = Medical Council. 2024;(11):93–99. (In Russ.) https://doi.org/10.21518/ms2024-260

Views: 231


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)