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The role of beta blockers in the treatment of cardiovascular diseases

https://doi.org/10.21518/ms2024-467

Abstract

Beta-blockers are used to treat various cardiovascular diseases, including hypertension and chronic heart failure. They act by suppressing the effects of catecholamines through various pathways and affect heart rate, strength, and renin release, providing antihypertensive and anti-ischemic effects. The individual effects of various drugs on clinical outcomes in this group were determined according to characteristics of the patient, underlying disease, and type of beta-blocker used. In recent years, beta-blockers have faced a serious obstacle when new guidelines on hypertension suggest their use as second-line therapy after angiotensin converting enzyme inhibitors, angiotensin receptor blockers and slow calcium channel blockers in the absence of clear indications. In fact, these recommendations were based on meta-analyses that showed that beta-blockers have fewer beneficial effects on overall mortality, cardiovascular events, and brain stroke. In addition, according to currently available data, the appointment of beta-blockers for diseases such as heart failure with preserved ejection fraction and stable coronary heart disease can cause more harm than good outcomes. Bisoprolol is a beta-blocker with the highest selectivity for beta1-adrenergic receptors, which determines the rare frequency of side effects that develop because of its use. This review presents current data on the use of beta-blockers for treating cardiovascular diseases, with an emphasis on the use of bisoprolol.

About the Authors

V. S. Chulkov
Yaroslav the Wise Novgorod State University
Russian Federation

Vasiliy S. Chulkov, Dr. Sci. (Med.), Associate Professor, Professor at the Department of Internal Medicine

41, Bolshaya Sankt-Peterburgskaya St., Veliky Novgorod, 173003



M. Z. Gasanov
Yaroslav the Wise Novgorod State University
Russian Federation

Mitkhat Z. Gasanov, Cand. Sci. (Med.), Associate Professor, Associate Professor at the Department of Internal Medicine

41, Bolshaya Sankt-Peterburgskaya St., Veliky Novgorod, 173003



O. V. Azovtseva
Yaroslav the Wise Novgorod State University
Russian Federation

Olga V. Azovtseva, Dr. Sci. (Med.), Associate Professor, Head at the Department of Microbiology, Immunology and Infectious Diseases

41, Bolshaya Sankt-Peterburgskaya St., Veliky Novgorod, 173003



E. E. Minina
South Ural State Medical University
Russian Federation

Elena E. Minina, Cand. Sci. (Med.), Associate Professor at the Department of Faculty Pediatrics named after N.S. Tyurina

64, Vorovskiy St., Chelyabinsk, 454092



Vl. S. Chulkov
South Ural State Medical University
Russian Federation

Vladislav S. Chulkov, Cand. Sci. (Med.), Associate Professor of the Department of Faculty Therapy

64, Vorovskiy St., Chelyabinsk, 454092



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Chulkov VS, Gasanov MZ, Azovtseva OV, Minina EE, Chulkov VS. The role of beta blockers in the treatment of cardiovascular diseases. Meditsinskiy sovet = Medical Council. 2024;(16):28-36. (In Russ.) https://doi.org/10.21518/ms2024-467

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