Immunological aspects of arterial hypertension during gestation

Introduction. Immune mechanisms are currently recognized as an integral part of the multifactorial etiology of hypertension and related organ damage.

Aim. To study autoimmune antibodies in pregnant women with chronic arterial hypertension for the prediction and prevention placenta-associated pregnancy complications, which in turn will reduce the incidence of adverse perinatal pregnancy outcomes.

Materials and methods. The study included 115 patients, 85 patients (the main group) with hypertension, 30 patients (the control group) with the physiological course of pregnancy, without hypertension. All patients in the study groups underwent the determination of autoimmune antibodies using ELIPP complex methods.

Results. A statistical deviation of the spectrum of autoimmune antibodies was observed in women with arterial hypertension, namely, a deviation of the spectrum to β2 – glycoprotein, autoantibodies to collagen, autoantibodies to protein S100, autoantibodies to cytoplasmic antigen of vascular endothelial cells (ANCA), autoantibodies to platelet membrane protein (TrM), autoantibodies to membrane antigen of glomerular kidney cells (KiMS).

Conclusions. The results of the study demonstrate the role of autoantibodies in the development of placenta-associated pregnancy complications in patients with chronic arterial hypertension. The determination of autoimmune antibodies will reduce the frequency of adverse perinatal outcomes.

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