Vascular dizziness
https://doi.org/10.21518/ms2025-303
Abstract
Dizziness is a common symptom that can stem from a range of pathophysiological mechanisms and occurs in many diseases. While dizziness is usually due to benign causes, it can sometimes signal serious, life-threatening illnesses. Focusing on the time course enables symptoms to be categorized into acute vestibular syndrome, episodic vestibular syndrome and chronic vestibular syndrome. Cerebrovascular pathology can be a cause of vestibular dizziness. In this case, transient isolated dizziness is one of the most common precursors of a transient ischemic attack in the vertebrobasilar basin. Ischemic stroke is considered as the most common cause of central acute vestibular syndrome. Strokes manifested by vestibular symptoms frequently occur due to damage to the brainstem or cerebellum, but can also be observed due to damage to the cerebral hemispheres. Cerebral small vessel disease is a significant factor in the development of dizziness in the elderly. Discriminating vascular causes in patients with acute vertigo is challenging, especially when associated neurological symptoms are not evident. In recent years, several bedside diagnostic techniques have been developed to effectively differentiate between peripheral and central vertigo. Diagnostic criteria for vascular vertigo were established and published by the International Barany Society for the classification of vascular vertigo into several types: definite acute prolonged vascular dizziness, probable acute prolonged vascular dizziness, transient and acute dizziness in evolution, as well as probable acute dizziness in evolution and probable transient dizziness. For the treatment of dizziness, pharmacological, physiotherapeutic, psychotherapeutic/behavioural and, less frequently, surgical approaches may be considered. Combination of different methods is often used. The choice of therapy depends on the pathophysiology and etiology of dizziness.
About the Authors
N. V. PizovaRussian Federation
Nataliia V. Pizova, Dr. Sci. (Med.), Professor of the Department of Nervous Diseases with Medical Genetics and Neurosurgery
5, Revolutsionnaya St., Yaroslavl, 150000
A. V. Pizov
Russian Federation
Aleksandr V. Pizov, Cand. Sci. (Biol.), Associate Professor of the Department of Methods of Teaching Natural Sciences and Mathematics in Primary Schools
5, Revolutsionnaya St., Yaroslavl, 150000
References
1. Martins TF, Mancini PC, de Souza LM, Santos JN. Prevalence of dizziness in the population of Minas Gerais, Brazil, and its association with demographic and socioeconomic characteristics and health status. Braz J Otorhinolaryngol. 2017;83(1):29–37. https://doi.org/10.1016/j.bjorl.2016.01.015.
2. Neuhauser HK. The epidemiology of dizziness and vertigo. Handb Clin Neurol. 2016;137:67–82. https://doi.org/10.1016/B978-0-444-63437-5.00005-4.
3. Agrawal Y, Carey JP, Della Santina CC, Schubert MC, Minor LB. Disorders of balance and vestibular function in US adults: Data from the National Health and Nutrition Examination Survey, 2001–2004. Arch Intern Med. 2009;169(10):938–944. https://doi.org/10.1001/archinternmed.2009.66.
4. Kroenke K, Hoffman RM, Einstadter D. How common are various causes of dizziness? A critical review. South Med J. 2000;93(2):160–167. Available at: https://www.sci-hub.ru/10.1097/00007611-200002000-00001.
5. Kwong EC, Pimlott NJ. Assessment of dizziness among older patients at a family practice clinic: A chart audit study. BMC Fam Pract. 2005;6(1):2. https://doi.org/10.1186/1471-2296-6-2.
6. Schifino E, Joffily L, Koohi N, Kaski D. Sex differences in dizziness diagnoses across acute and chronic neurological settings. Neurol Sci. 2025;46(6):2779–2787. https://doi.org/10.1007/s10072-025-08085-y.
7. Xing Y, Si L, Zhang W, Wang Y, Li K, Yang X. Etiologic distribution of dizziness/vertigo in a neurological outpatient clinic according to the criteria of the international classification of vestibular disorders: a single-center study. J Neurol. 2024;271(5):2446–2457. https://doi.org/10.1007/s00415-023-12166-3.
8. Oh EH, Shin JH, Cho JW, Choi SY, Choi KD, Rhee JK, Choi JH. Episodic Vestibular Syndrome with Hyperventilation-Induced Downbeat Nystagmus. Cerebellum. 2021;20(5):796–803. https://doi.org/10.1007/s12311-020-01204-9.
9. Martin-Sanz E, Esteban J, Vaduva C, Sanz R, Lopez-Escamez JA. Highfrequency sensorineural hearing loss associated with vestibular episodic syndrome. Clin Otolaryngol. 2017;42(4):856–859. https://doi.org/10.1111/coa.12710.
10. von Brevern M, Bertholon P, Brandt T, Fife T, Imai T, Nuti D, Newman-Toker D. Benign paroxysmal positional vertigo: Diagnostic criteria. J Vestib Res. 2015;25(3-4):105–117. Available at: https://journals.sagepub.com/doi/abs/10.3233/VES-150553.
11. Imai T, Takeda N, Ikezono T, Shigeno K, Asai M, Watanabe Y, Suzuki M. Classification, diagnostic criteria and management of benign paroxysmal positional vertigo. Auris Nasus Larynx. 2017;44(1):1–6. https://doi.org/10.1016/j.anl.2016.03.013.
12. Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M et al. Diagnostic criteria for Menière’s disease. J Vestib Res. 2015;25(1):1–7. Available at: https://journals.sagepub.com/doi/abs/10.3233/VES-150549.
13. Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J et al. Vestibular migraine: diagnostic criteria. J Vestib Res. 2012;22(4):167–172. Available at: https://journals.sagepub.com/doi/abs/10.3233/VES-2012-0453.
14. Kim JS, Newman-Toker DE, Kerber KA, Jahn K, Bertholon P, Waterston J et al. Vascular vertigo and dizziness: Diagnostic criteria. J Vestib Res. 2022;32(3):205–222. Available at: https://journals.sagepub.com/doi/full/10.3233/VES-210169.
15. Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM et al. Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society. J Vestib Res. 2017;27(4):177–189. Available at: https://journals.sagepub.com/doi/full/10.3233/VES-170619.
16. Staab JP, Eckhardt-Henn A, Horii A, Jacob R, Strupp M, Brandt T, Bronstein A. Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the committee for the Classification of Vestibular Disorders of the Bárány Society. J Vestib Res. 2017;27(4):191–208. Available at: https://journals.sagepub.com/doi/full/10.3233/VES-170622.
17. Paul NL, Simoni M, Rothwell PM. Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study. Lancet Neurol. 2013;12(1):65–71. https://doi.org/10.1016/S14744422(12)70299-5.
18. Hoshino T, Nagao T, Mizuno S, Shimizu S, Uchiyama S. Transient neurological attack before vertebrobasilar stroke. J Neurol Sci. 2013;325(1-2):39–42. https://doi.org/10.1016/j.jns.2012.11.012.
19. Choi JH, Park MG, Choi SY, Park KP, Baik SK, Kim JS, Choi KD. Acute Transient Vestibular Syndrome: Prevalence of Stroke and Efficacy of Bedside Evaluation. Stroke. 2017;48(3):556–562. https://doi.org/10.1161/STROKEAHA.116.015507.
20. Grad A, Baloh RW. Vertigo of vascular origin. Clinical and electronystagmographic features in 84 cases. Arch Neurol. 1989;46(3):281–284. https://doi.org/10.1001/archneur.1989.00520390047014.
21. Kim HA, Oh EH, Choi SY, Choi JH, Park JY, Lee H, Choi KD. Transient Vestibular Symptoms Preceding Posterior Circulation Stroke: A Prospective Multicenter Study. Stroke. 2021;52(6):e224–e228. https://doi.org/10.1161/STROKEAHA.120.032488.
22. Tarnutzer AA, Gold D, Wang Z, Robinson KA, Kattah JC, Mantokoudis G et al. Impact of Clinician Training Background and Stroke Location on Bedside Diagnostic Test Accuracy in the Acute Vestibular Syndrome – A MetaAnalysis. Ann Neurol. 2023;94(2):295–308. https://doi.org/10.1002/ ana.26661.
23. d’Annunzio A, Arboix A, García-Eroles L, Sánchez-López MJ. Vertigo in Acute Stroke Is a Predictor of Brain Location but Is Not Related to Early Outcome: The Experience of Sagrat Cor Hospital of Barcelona Stroke Registry. Biomedicines. 2022;10(11):2830. https://doi.org/10.3390/ biomedicines10112830.
24. Chan YM, Wong Y, Khalid N, Wastling S, Flores‐Martin A, Frank L et al. Prevalence of acute dizziness and vertigo in cortical stroke. Eur J Neurol. 2021;28(9):3177–3181. https://doi.org/10.1111/ene.14964.
25. Eguchi S, Hirose G, Miaki M. Vestibular symptoms in acute hemispheric strokes. J Neurol. 2019;266(8):1852–1858. https://doi.org/10.1007/s00415019-09342-9.
26. Tarnutzer AA, Lee SH, Robinson KA, Wang Z, Edlow JA, Newman-Toker DE. Ed misdiagnosis of cerebrovascular events in the era of modern neuroimaging: A meta-analysis. Neurology. 2017;88(15):1468–1477. https://doi.org/10.1212/WNL.0000000000003814.
27. Kerber KA, Meurer WJ, Brown DL, Burke JF, Hofer TP, Tsodikov A et al. Stroke risk stratification in acute dizziness presentations: A prospective imagingbased study. Neurology. 2015;85(21):1869–1878. https://doi.org/10.1212/WNL.0000000000002141.
28. Tu LH, Malhotra A, Venkatesh AK, Taylor RA, Sheth KN, Yaesoubi R et al. Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLoS ONE. 2023;18(3):e0280752. https://doi.org/10.1371/journal.pone.0280752.
29. Caplan LR, Wityk RJ, Glass TA, Tapia J, Pazdera L, Chang HM et al. New England Medical Center Posterior Circulation registry. Ann Neurol. 2004;56(3):389–398. https://doi.org/10.1002/ana.20204.
30. Rennert RC, Wali AR, Steinberg JA, Santiago-Dieppa DR, Olson SE, Pannell JS, Khalessi AA. Epidemiology, Natural History, and Clinical Presentation of Large Vessel Ischemic Stroke. Neurosurgery. 2019;85(Suppl. 1):S4–S8. https://doi.org/10.1093/neuros/nyz042.
31. Saber Tehrani AS, Kattah JC, Kerber KA, Gold DR, Zee DS, Urrutia VC, Newman-Toker DE. Diagnosing Stroke in Acute Dizziness and Vertigo: Pitfalls and Pearls. Stroke. 2018;49(3):788–795. https://doi.org/10.1161/STROKEAHA.117.016979.
32. Kikkawa Y, Suzuki K, Teranishi A, Tachikawa T, Kurita H. Ruptured intrameatal anterior inferior cerebellar artery aneurysm associated with obstructed internal auditory artery in a patient with sudden hearing loss and vertigo. Acta Neurochir. 2019;161(2):403–406. https://doi.org/10.1007/s00701-018-3771-x.
33. Ogasawara Y, Ito K, Ohkuma H. Atypical Presentation of Aneurysmal Subarachnoid Hemorrhage: Incidence and Clinical Importance. J Stroke Cerebrovasc Dis. 2016;25(5):1208–1214. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.004.
34. Sparaco M, Ciolli L, Zini A. Posterior circulation ischaemic stroke – a review part I: anatomy, aetiology and clinical presentations. Neurol Sci. 2019;40(10):1995–2006. https://doi.org/10.1007/s10072-019-03977-2.
35. Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome. Stroke. 2009;40(11): 3504–3510. https://doi.org/10.1161/STROKEAHA.109.551234.
36. Arch AE, Weisman DC, Coca S, Nystrom KV, Wira 3rd CR, Schindler JL. Missed Ischemic Stroke Diagnosis in the Emergency Department by Emergency Medicine and Neurology Services. Stroke. 2016;47(3):668–673. https://doi.org/10.1161/STROKEAHA.115.010613.
37. Lee CC, Su YC, Ho HC, Hung SK, Lee MS, Chou P, Huang YS. Risk of stroke in patients hospitalized for isolated vertigo: a four-year follow-up study. Stroke. 2011;42(1):48–52. https://doi.org/10.1161/STROKEAHA.110.597070.
38. Lee CC, Ho HC, Su YC, Chiu BC, Lee YD, Chou P et al. Increased risk of vascular events in emergency room patients discharged home with diagnosis of dizziness or vertigo: a 3-year follow-up study. PLoS ONE. 2012;7(4):e35923. https://doi.org/10.1371/journal.pone.0035923.
39. Pizova NV, Pizov AV. Outpatient management of patients with vascular cognitive impairment. Meditsinskiy Sovet. 2024;18(12):31–38. (In Russ.) https://doi.org/10.21518/ms2024-311.
40. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol. 2019;18(7):684–696. https://doi.org/10.1016/S1474-4422(19)30079-1.
41. Staals J, Makin SD, Doubal FN, Dennis MS, Wardlaw JM. Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology. 2014;83(14):1228–1234. https://doi.org/10.1212/WNL.0000000000000837.
42. Litak J, Mazurek M, Kulesza B, Szmygin P, Litak J, Kamieniak P, Grochowski C. Cerebral Small Vessel Disease. Int J Mol Sci. 2020;21(24):9729. https://doi.org/10.3390/ijms21249729.
43. Blevins BL, Vinters HV, Love S, Brittney L, Wilcock DM, Grinberg LT et al. Brain arteriolosclerosis. Acta Neuropathol. 2020;141(1):1–24. https://doi.org/10.1007/s00401-020-02235-6.
44. Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease – one peptide, two pathways. Nat Rev Neurol. 2020;16(1):30–42. https://doi.org/10.1038/s41582-019-0281-2.
45. Ahmad H, Cerchiai N, Mancuso M, Casani AP, Bronstein AM. Are white matter abnormalities associated with “unexplained dizziness”? J Neurol Sci. 2015;358(1-2):428–431. https://doi.org/10.1016/j.jns.2015.09.006.
46. Cerchiai N, Mancuso M, Navari E, Giannini N, Casani AP. Aging with Cerebral Small Vessel Disease and Dizziness: The Importance of Undiagnosed Peripheral Vestibular Disorders. Front Neurol. 2017;8:241. https://doi.org/10.3389/fneur.2017.00241.
47. Ibitoye RT, Castro P, Cooke J, Allum J, Arshad Q, Murdin L et al. A link between frontal white matter integrity and dizziness in cerebral small vessel disease. Neuroimage Clin. 2022;35:103098. https://doi.org/10.1016/j.nicl.2022.103098.
48. Newman-Toker DE, Della Santina CC, Blitz AM. Vertigo and hearing loss. Handb Clin Neurol. 2016;136:905–921. https://doi.org/10.1016/B9780-444-53486-6.00046-6.
49. Shah VP, Oliveira JESL, Farah W, Seisa M, Kara Balla A, Christensen A et al. Diagnostic accuracy of neuroimaging in emergency department patients with acute vertigo or dizziness: a systematic review and meta-analysis for the guidelines for reasonable and appropriate care in the emergency department. Acad Emerg Med. 2023;30(5):517–530. https://doi.org/10.1111/acem.14561.
50. Edlow J. A negative non-contrast CT is insufficient to exclude a cerebellar infarct. Emerg Med J. 2022;39(7):564–565. https://doi.org/10.1136/emermed-2022-212404.
51. Saber Tehrani AS, Kattah JC, Mantokoudis G, Pula JH, Nair D, Blitz A et al. Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms. Neurology. 2014;83(2):169–173. https://doi.org/10.1212/WNL.0000000000000573.
52. Tarnutzer AA, Edlow JA. Bedside Testing in Acute Vestibular Syndrome – Evaluating HINTS Plus and Beyond – A Critical Review. Audiol Res. 2023;13(5):670–685. https://doi.org/10.3390/audiolres13050059.
53. Zhiznevskiy DV, Zamergrad MV, Grachev SP. Modern concepts of vascular vertigo. Neurology, Neuropsychiatry, Psychosomatics. 2023;15(4):4–11. (In Russ.) https://doi.org/10.14412/2074-2711-2023-4-4-11.
54. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN et al. Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke. 2012;43(6):1484–1489. https://doi.org/10.1161/STROKEAHA.111.646414.
55. Wang W, Zhang Y, Pan Q, Liu J, Zhu Y, Tan G et al. Central nystagmus plus ABCD2 identifying stroke in acute dizziness presentations. Acad Emerg Med. 2021;28(10):1118–1123. https://doi.org/10.1111/acem.14295.
56. Pizova NV, Pizov AV. Repeated ischemic stroke and its prevention. Meditsinskiy Sovet. 2024;18(12):8–14. (In Russ.) https://doi.org/10.21518/ms2024-261.
57. Scholtz AW, Hahn A, Stefflova B, Medzhidieva D, Ryazantsev SV, Paschinin A et al. Efficacy and Safety of a Fixed Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg vs Betahistine Dihydrochloride 16 mg in Patients with Peripheral Vestibular Vertigo: A Prospective, Multinational, Multicenter, Double-Blind, Randomized, Non-inferiority Clinical Trial. Clin Drug Investig. 2019;39(11):1045–1056. https://doi.org/10.1007/s40261019-00858-6.
58. Otto V, Fischer B, Schwarz M, Baumann W, Preibisch-Effenberger R. Treatment of vertebrobasilar insufficiency-associated vertigo with a fixed combination of cinnarizine and dimenhydrinate. Int Tinnitus J. 2008;14(1):57–67. Available at: https://www.tinnitusjournal.com/articles/treatment-of-vertebrobasilar-insufficiency-associated-vertigo-with-a-fixed-combinationof-cinnarizine-and-dimenhydrinate.pdf.
59. Martines F, Agrifoglio M, Bentivegna D, Mucia M, Salvago P, Sireci F et al. Treatment of tinnitus and dizziness associated vertebrobasilar insufficiency with a fixed combination of cinnarizine and dimenhydrinate. Acta Med Mediterr. 2012;28:291–296. Available at: https://iris.unipa.it/retrieve/handle/10447/73647/72949/291.pdf.
60. Scholtz AW, Waldfahrer F, Hampel R, Weisshaar G. Efficacy and Safety of a Fixed-Dose Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg in the Treatment of Patients with Vestibular Vertigo: An Individual Patient Data Meta-Analysis of Randomised, Double-Blind, Controlled Clinical Trials. Clin Drug Investig. 2022;42(9):705–720. https://doi.org/10.1007/s40261-022-01184-0.
61. Towse G. Cinnarizine – a labyrinthine sedative. J Laryngol Otol. 1980;94(9):1009–1015. https://doi.org/10.1017/S0022215100089787.
62. Schremmer D, Bognar-Steinberg I, Baumann W, Pytel J. Efficacy and Tolerability of a Fixed Combination of Cinnarizine and Dimenhydrinate in Treatment of Vertigo. Clin Drug Invest. 1999;18:355–368. https://doi.org/10.2165/00044011-199918050-00003.
63. Scholtz AW, Ilgner J, Loader B, Pritschow BW, Weisshaar G. Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice. Wien Klin Wochenschr. 2016;128(9-10):341–347. https://doi.org/10.1007/s00508015-0905-5.
64. Kim OV, Majidova YoN, Nosirova DSh. Optimizing treatment of patients with vertigo. Bulletin of the Kazakh National Medical University. 2015;(2):404–405. (In Russ.) Available at: https://www.elibrary.ru/ywgihb.
65. Scholtz AW, Schwarz M, Baumann W, Kleinfeldt D, Scholtz HJ. Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallelgroup clinical study. Clin Ther. 2004;26(6):866–877. https://doi.org/10.1016/ S0149-2918(04)90130-0.
Review
For citations:
Pizova NV, Pizov AV. Vascular dizziness. Meditsinskiy sovet = Medical Council. 2025;19(13):61-68. (In Russ.) https://doi.org/10.21518/ms2025-303