Use of estradiol valerate in women with thin endometrium in ART cycles
https://doi.org/10.21518/ms2025-335
Abstract
Introduction. Patients with infertility often require the help of assisted reproductive technologies to solve their problem. Two thirds of failures in ART cycles are associated with insufficient endometrial receptivity.
Aim. To evaluate the effectiveness of using estradiol valerate 2 mg (Progynova®) in women with thin endometrium in ART cycles.
Materials and methods. The study included patients with a thin endometrium ≤ 7.0 mm according to the ultrasound examination (US) of the pelvic organs on the 10–14th day of the menstrual cycle (peak of luteinizing hormone (LH) in the blood or on the day of progesterone administration in the hormone replacement therapy cycle). Patients with a thin endometrium (n = 74) were divided into two groups: the first group (n = 43) – patients with chronic endometritis established by histological examination and immunohistochemistry (IHC); group 2 (n=31) – patients with a thin endometrium without chronic endometritis. All patients received estradiol valerate according to one of the following regimens: 4 mg estradiol valerate in a natural cycle from the moment the dominant follicle reached a diameter of 13 mm or 4 mg estradiol valerate from day 3 of the menstrual cycle.
Results. Administration of estradiol valerate statistically significantly increased the endometrial thickness in women with thin endometrium (p < 0.05). The increase in endometrial thickness in patients of group 1 averaged 1.9279 mm, in patients of group 2 – 2.09 mm. The average endometrial thickness before treatment with estradiol valerate was 6.315 (4.7; 7.0) mm, after treatment – 8.311 (5.6; 11.0). 70 of 74 (94.6%) patients had an endometrial thickness of > 7 mm. Pregnancy in an IVF or PE cycle occurred in 44 patients with thin endometrium (62.5%) after treatment with estradiol valerate.
Conclusions. The use of estradiol valerate in IVF and ET cycles increases the thickness of the endometrium and increases the frequency of pregnancy and live birth in patients with a thin endometrium.
About the Authors
A. V. Solovyeva
Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Alina V. Solovyeva, Dr. Sci. (Med.), Professor at the Department of Obstetrics and Gynecology with the course of Perinatology
6, Miklukho-Maklai St., Moscow, 117198
K. S. Ermolenko
LLC “Health Clinic”
Russian Federation
Russian Federation
Kristina S. Ermolenko, Cand. Sci. (Med.), Deputy Chief Physician
23, Bldg. 2, Bolshaya Novodmitrovskaya St., Moscow, 127015
L. T. Kulumbegova
LLC “Health Clinic”
Russian Federation
Russian Federation
Leyla T. Kulumbegova, Cand. Sci. (Med.), Chief Physician
23, Bldg. 2, Bolshaya Novodmitrovskaya St., Moscow, 127015
D. S. Mamchich
Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Daria S. Mamchich, Resident of the Department of Obstetrics and Gynecology with the course of Perinatology
6, Miklukho-Maklai St., Moscow, 117198
M. A. Spitsyna
Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Maria A. Spitsyna, Postgraduate Student of the Department of Obstetrics and Gynecology with the course of Perinatology
6, Miklukho-Maklai St., Moscow, 117198
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For citations:
Solovyeva AV, Ermolenko KS, Kulumbegova LT, Mamchich DS, Spitsyna MA. Use of estradiol valerate in women with thin endometrium in ART cycles. Meditsinskiy sovet = Medical Council. (In Russ.) https://doi.org/10.21518/ms2025-335
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