Modern possibilities of immunocorrection of inflammatory diseases of the oropharynx

One of the determining factors of the effectiveness of treatment of upper respiratory tract infections is the immunological reactivity of the mucous membranes. In this context, understanding the individual pathophysiological mechanisms of disease development and their clinical course, depending on the state of general and local immunity, will allow improving treatment tactics and achieving positive results at an earlier date. To substantiate the prospects of using a multicomponent phytonerating drug with a multidirectional effect in the treatment of inflammatory diseases of the upper respiratory tract with an emphasis on unique pharmacokinetic parameters and pharmacodynamic parameters. The analysis of literature sources highlighting topical issues of etiopathogenetic mechanisms of upper respiratory tract infections, clinical features, and the expe­rience of researchers using phytoniringovyh drugs and their own observations. Databases of literature data were used: RSCI, Web of Science, PubMed, Google Scholar, Scopus, etc., according to keywords, ENT infections, upper respiratory tract infection, immunity, immunoglobulins, herbal medicines, phytotherapy, with a search depth of more than ten years. Among the reasons for seeking specialized otorhinolaryngological care, upper respiratory tract infections occupy a leading place. The key pathogens are RNA-containing viruses of four families and DNA-containing viruses of two families. The main effector of adaptive immunity, protection of the mucous membranes of the upper respiratory tract, is secretory class A immunoglobulin. There is a tendency to decrease the content of IFN-a and sIdA in the first days of the disease, which can be explained by a decrease in infectious protection, therefore, the search for drugs capable of affecting the local immune response is justified, and the medicinal phy­topreparation Tonsilgon N. meets these requirements. The inclusion of the medicinal phytopreparation in the basic therapy of upper respiratory tract infections will achieve high results in relieving clinical symptoms by enhancing the local immune response of the oropharyngeal mucosa.

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