Antiseptics in the perioperative period in children with Pirogov-Waldeyer's ring hypertrophy
https://doi.org/10.21518/ms2025-462
Abstract
Improving the effectiveness of perioperative therapy in children with pathology of the tonsils of the Pirogov-Waldeyer’s lymphoepithelial ring remains a priority task for practical otorhinolaryngology and related specialties. The article discusses the main epidemiological and etiopathogenetic aspects of the formation of pathological conditions of the lymphoepithelial pharyngeal ring. The well-founded and demanded principles of perioperative therapy using topical antiseptic and disinfectants are outlined, the most progressive of which are drugs with the main active ingredient ambazone. Special attention is paid to the mechanisms of achieving maximum therapeutic concentrations of the active substance with topical application, which make it possible to stop inflammation in a short time without exerting a systemic effect on the child’s body. The mechanisms of bacteriostatic action of an antiseptic drug against the most frequently verified microorganisms (Streptococcus haemolyticus, Streptococcus viridans, Pneumococcus) are described in detail. The rationale and prospects for the use of antiseptic drugs with the active substance ambazone are demonstrated by clinical examples.
About the Authors
V. S. Isachenko
Saint Petersburg Research Institute of Ear, Throat, Nose and Speech;
Saint Petersburg State University
Russian Federation
Russian Federation
Vadim S. Isachenko, Dr. Sci. (Med.), Associate Professor, Senior Researcher, Deputy Chief Physician for Surgery, Saint Petersburg Research Institute of Ear, Throat, Nose and Speech; Professor of the Department of Otorhinolaryngology and Ophthalmology, Medical Institute, Saint Petersburg State University
9, Bronnitskaya St., St Petersburg, 190013,
8A, 21st Liniya Vasilevskogo Ostrova St., St Petersburg, 199106
L. E. Shapovalov
Saint Petersburg Research Institute of Ear, Throat, Nose and Speech
Russian Federation
Russian Federation
Lev E. Shapovalov, Postgraduate Student
9, Bronnitskaya St., St Petersburg, 190013
M. V. Drozdova
Saint Petersburg Research Institute of Ear, Throat, Nose and Speech
Russian Federation
Russian Federation
Marina V. Drozdova, Dr. Sci. (Med.), Leading Researcher of the Department of Pathology of the Upper Respiratory Tract, Head of the Department of Reconstructive Surgery
9, Bronnitskaya St., St Petersburg, 190013
S. N. Larionova
Saint Petersburg Research Institute of Ear, Throat, Nose and Speech
Russian Federation
Russian Federation
Sofya N. Larionova, Otorhinolaryngologist of the Pediatric Surgical Department, Researcher
9, Bronnitskaya St., St Petersburg, 190013
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Review
For citations:
Isachenko VS, Shapovalov LE, Drozdova MV, Larionova SN. Antiseptics in the perioperative period in children with Pirogov-Waldeyer's ring hypertrophy. Meditsinskiy sovet = Medical Council. 2025;(18):82-88. (In Russ.) https://doi.org/10.21518/ms2025-462
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